scholarly journals AIUM Practice Parameter for the Performance of Scrotal Ultrasound Examinations

2021 ◽  
Keyword(s):  
Practice Parameter ◽  
Scrotal Ultrasound

Testicular Involvement is a Hallmark of Apo A-I Leu75Pro Mutation Amyloidosis

2020 ◽  
Vol 105 (12) ◽  
pp. e4758-e4766
Author(s):  
Andrea Delbarba ◽  
Paolo Facondo ◽  
Simona Fisogni ◽  
Claudia Izzi ◽  
Filippo Maffezzoni ◽  
...  
Keyword(s):  
Follicle Stimulating Hormone ◽  
Organ Damage ◽  
University Hospital ◽  
Reproductive Hormone ◽  
Testicular Dysfunction ◽  
Amyloid Deposits ◽  
Scrotal Ultrasound ◽  
Almost All ◽  
The University ◽  
Male Subjects

Abstract Context Apo A-I Leu75Pro is a rare hereditary form of amyloidosis that mainly involves the kidney, the liver, and the testis. Objective To define the characteristics of organ damage and testis impairment in the largest cohort collected to date of men with Apo A-I Leu75Pro amyloidosis. Design, Setting, and Patients Retrospective study from a prospectively collected database of 129 male subjects >18 years with Apo A-I Leu75Pro amyloidosis from a reference center at the University Hospital of Brescia, Italy. Main outcome measures We evaluated liver and renal function, scrotal ultrasound, reproductive hormone levels, testis biopsy, hypogonadal symptoms, and fertility. Results Progressive involvement of testis, kidney, and liver was observed in 96/129 (74.4%) cases. Testis impairment was found in 88/129 patients (68.2%), liver in 59 (45.7%) and renal in 50 (38.8%). Testis damage was often the first manifestation of the disease and the only dysfunction in 30% of younger patients (<38 years). Testicular involvement was characterized mainly by primary (73/88 patients, 83.0%) and subclinical (8/88, 9.1%) hypogonadism. Almost all (85/88, 96.6%) also had high follicle-stimulating hormone, suggesting a primary global damage of endocrine and spermatogenic functions, and 30% of them did not conceive. Macroorchidism was found in 53/88 (60.2%) patients, especially in men <54 years (30/33, 90.9%). Apo A-I amyloid deposits were found in Sertoli cells, germinal epithelium, and vessel walls. Conclusion In men with Apo A-I Leu75Pro amyloidosis, testicular involvement is the hallmark of the disease, characterized by global primary testicular dysfunction and macroorchidism due to amyloid deposits.

Posterior vaginectomy as a practice parameter in rectal carcinoma

1994 ◽  
Vol 37 (5) ◽  
pp. 513-514 ◽  
Author(s):  
Jason D. Green ◽  
James T. Evans ◽  
Ralph Ger
Keyword(s):  
Rectal Carcinoma ◽  
Practice Parameter

Disease Management of Atopic Dermatitis: a Practice Parameter

1997 ◽  
Vol 79 (3) ◽  
pp. 197-211 ◽  
Author(s):  
Donald Y M Leung ◽  
Jon M Hanifin ◽  
Ernest N Charlesworth ◽  
James T Li ◽  
I Leonard Bernstein ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Disease Management ◽  
Practice Parameter

Letters to the Editor

PEDIATRICS ◽  
1995 ◽  
Vol 95 (4) ◽  
pp. 617-617
Author(s):  
Marsha Walker
Keyword(s):  
Quality Improvement ◽  
Breast Milk ◽  
Breast Feeding ◽  
Practice Parameter ◽  
Letters To The Editor ◽  
Term Newborn ◽  
Breast Fed

I read with interest the report by the Provisional Committee for Quality Improvement and Subcommittee on Hyperbilirubinemia (Pediatrics 1994;94:558-565) entitled, "Practice Parameter: Management of Hyperbilirubinemia in the Healthy Term Newborn." I wish to make a couple of comments on jaundice and the breast-fed newborn. It was gratifying to see recommendations discouraging the interruption of breast-feeding and eliminating the use of supplemental water or dextrose and water in this situation. Many jaundiced breast-fed newborns simply need more breast milk, ie, more feedings and a check to see that the newborn is swallowing milk at breast.

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