Association Between Shear Wave Elastography of Virtual Touch Tissue Imaging Quantification Parameters and the Ki‐67 Proliferation Status in Luminal‐Type Breast Cancer

2018 ◽  
Vol 38 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Yubo Liu ◽  
Yini Huang ◽  
Jing Han ◽  
Jianwei Wang ◽  
Fei Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Shear Wave ◽  
Shear Wave Elastography ◽  
Tissue Imaging ◽  
Ki 67 ◽  
Luminal Type ◽  
Virtual Touch Tissue Imaging

scholarly journals Shear Wave Elastography-Assisted Ultrasound Breast Image Analysis and Identification of Abnormal Data

2022 ◽  
Vol 2022 ◽  
pp. 1-10
Author(s):  
Caoxin Yan ◽  
Zhiyan Luo ◽  
Zimei Lin ◽  
Huilin He ◽  
Yunkai Luo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Shear Wave ◽  
Shear Wave Elastography ◽  
Lymph Node Status ◽  
Axillary Lymph ◽  
Axillary Lymph Node Status ◽  
Ki 67 ◽  
Freeze Thaw ◽  
Quantitative Metrics ◽  
Her 2

In this paper, shear wave elastography was used to study and analyze the images of the breast in-depth and identify the abnormal image data. Sixty breast lesions were evaluated, and quantitative metrics were reproducible in the static and dynamic modes of shear wave elastography with a higher interobserver agreement in dynamic qualitative metrics than in the static mode. There were no statistically significant differences between the two modes of imaging in quantitative metrics, and quantitative metrics were more effective than qualitative metrics. Postoperative immunohistochemical expression of ER, PR, HER-2, Ki-67, molecular typing, pathological type, histological grading, and axillary lymph node status of breast cancer was obtained based on pathological results. The correlation between mass size, patient age, and WiMAX values of breast cancer masses was analyzed using Pearson correlation, and the differences in SWVmax values of breast cancer masses between different expressions of immunohistochemical parameters ER, PR, HER-2, Ki-67, and axillary lymph node status were compared using tests. The variables with correlations and differences were included in the multiple linear regression analysis to assess the factors influencing the SWVmax values. The performance of TDPM, SPM, and TSPM was compared using PVA body models with different freeze-thaw cycles. The results showed that TSPM performed better than SPM in general, and TDPM showed excellent performance because of high temporal resolution and low random error, especially when the number of freeze-thaw cycles increased and the hardness of the PVA body mold increased. Measurements at different depths of inhomogeneous body models also showed that the TDPM method was less affected by depth, and the results were more stable. Finally, the reliability of the shear wave velocity (SWS) measured by the TDPM and SPM methods was investigated using porcine ligament tissue, and the results showed that the mean values of SWS goodness of fit for TDPM and SPM were 0.94 and 0.87, respectively, and the estimated elastic modulus of TDPM was very close to the mechanical test results.

scholarly journals Value of shear wave elastography by virtual touch tissue imaging quantification in patients with diffuse thyroid gland pathology

2018 ◽  
Vol 48 (5) ◽  
pp. 993-998 ◽  
Author(s):  
Feride KURAL RAHATLI ◽  
Hale TURNAOĞLU ◽  
Nazlı Gülsoy KIRNAP ◽  
Özlem TURHAN İYİDİR ◽  
Kemal Murat HABERAL ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Shear Wave ◽  
Shear Wave Elastography ◽  
Tissue Imaging ◽  
Virtual Touch Tissue Imaging

Comparison of risk categories defined by Ki-67 and the EndoPredict test in luminal-type breast cancer

2018 ◽  
Author(s):  
A Noske ◽  
J Ettl ◽  
SI Anders ◽  
A Hapfelmeier ◽  
K Steiger ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ki 67 ◽  
Luminal Type ◽  
Risk Categories

scholarly journals Early assessment of shear wave elastography parameters foresees the response to neoadjuvant chemotherapy in patients with invasive breast cancer

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Juanjuan Gu ◽  
Eric C. Polley ◽  
Max Denis ◽  
Jodi M. Carter ◽  
Sandhya Pruthi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Shear Wave ◽  
Invasive Breast Cancer ◽  
Shear Wave Elastography ◽  
Early Prediction ◽  
Early Assessment ◽  
Significant Difference ◽  
Mass Size ◽  
Response To Neoadjuvant Chemotherapy

Abstract Background Early prediction of tumor response to neoadjuvant chemotherapy (NACT) is crucial for optimal treatment and improved outcome in breast cancer patients. The purpose of this study is to investigate the role of shear wave elastography (SWE) for early assessment of response to NACT in patients with invasive breast cancer. Methods In a prospective study, 62 patients with biopsy-proven invasive breast cancer were enrolled. Three SWE studies were conducted on each patient: before, at mid-course, and after NACT but before surgery. A new parameter, mass characteristic frequency (fmass), along with SWE measurements and mass size was obtained from each SWE study visit. The clinical biomarkers were acquired from the pre-NACT core-needle biopsy. The efficacy of different models, generated with the leave-one-out cross-validation, in predicting response to NACT was shown by the area under the receiver operating characteristic curve and the corresponding sensitivity and specificity. Results A significant difference was found for SWE parameters measured before, at mid-course, and after NACT between the responders and non-responders. The combination of Emean2 and mass size (s2) gave an AUC of 0.75 (0.95 CI 0.62–0.88). For the ER+ tumors, the combination of Emean_ratio1, s1, and Ki-67 index gave an improved AUC of 0.84 (0.95 CI 0.65–0.96). For responders, fmass was significantly higher during the third visit. Conclusions Our study findings highlight the value of SWE estimation in the mid-course of NACT for the early prediction of treatment response. For ER+ tumors, the addition of Ki-67improves the predictive power of SWE. Moreover, fmass is presented as a new marker in predicting the endpoint of NACT in responders.

scholarly journals Multiparametric ultrasound diagnosis of metastatic and lymphoproliferative changes in lymph nodes in primary-multiple malignant tumors, including breast cancer and lymphoma

2019 ◽  
Vol 8 (4) ◽  
pp. 37-44 ◽  
Author(s):  
E. V. Kovaleva ◽  
T. Yu. Danzanova ◽  
G. T. Sinyukova ◽  
P. I. Lepedatu ◽  
E. A. Gudilina ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Differential Diagnosis ◽  
Lymph Nodes ◽  
Shear Wave ◽  
Malignant Tumors ◽  
Shear Wave Elastography ◽  
Doppler Imaging ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Multiparametric Ultrasound

In this article, based on two clinical examples, the possibilities of multiparametric ultrasound in the differential diagnosis of metastatic and lymphoproliferative changes in lymph nodes in primary-multiple malignant tumors, including breast cancer and lym - phoma, are evaluated. Multiparameteric ultrasound includes B-mode, color and energy Doppler imaging, strain elastography, shear wave elastography and contrast-enhanced ultrasound (CEUS). Standardization and reproducibility of these ultrasound techniques will allow to objectify the study, obtaining specific indicators of shear wave velocity in the zones of interest and specific signs of contrast enhancement, which can be used as impor tant differential diagnostic tool in oncology.

Sign in / Sign up

Export Citation Format

Share Document