Diagnostic Value of Contrast-Enhanced Ultrasonography and Time-Intensity Curve in Differential Diagnosis of Cervical Metastatic and Tuberculous Lymph Nodes

2017 ◽  
Vol 37 (1) ◽  
pp. 83-92 ◽  
Author(s):  
Qiu-li Cui ◽  
Shan-shan Yin ◽  
Zhi-Hui Fan ◽  
Wei Yang ◽  
Song Wang ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Lymph Nodes ◽  
Diagnostic Value ◽  
Intensity Curve ◽  
Time Intensity Curve ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography

scholarly journals Quantitative Perfusion Analysis and Time Intensity Curve Analysis in Differential Diagnosis of Solid Pancreatic Tumors by Contrast-Enhanced Ultrasound. A Pilot Study

2017 ◽  
pp. 82-87 ◽  
Author(s):  
N. N. Askerova ◽  
Yu. A. Stepanova ◽  
I. E. Timina
Keyword(s):  
Differential Diagnosis ◽  
Contrast Agent ◽  
Curve Analysis ◽  
Contrast Enhanced Ultrasound ◽  
Intensity Curve ◽  
Time Intensity Curve ◽  
Time To Peak ◽  
Contrast Enhanced ◽  
Peak Parameter ◽  
Adenocarcinoma Of The Pancreas

Contrast-enhanced ultrasound began to develop rapidly  in recent years inRussia. Due to the physical properties of contrast agents it is possible to differentiate malignant and benign lesions. However, this method only involves a subjective evaluation of the obtained results. For the objectification of ultrasound with contrast enhancement implemented the function “TIC-analysis” (time intensity curve analysis).  The aim: to assess the clinical value of the TIC-analysis in the differential diagnosis of adenocarcinoma of the pancreas and chronic pseudotumoral pancreatitis by contrast – enhanced ultrasound.Materials and methods. In A.V. Vishnevsky Institute of surgery contrast – enhanced ultrasound and TIC-analysis was performed on 23 patients with focal lesions of the pancreas. All patients were operated on, tumors were verified morphologically: adenocarcinoma of the pancreas  in 18 (78%) patients, chronic pseudotumoral pancreatitis – in 5 (22%) patients.Results. The results about intensity of the tumors obtained by the TIC analysis do not allow to differentiate these pathological processes statistically significant (p > 0.05), which, in all probability, due to the fact that pancreatic  adenocarcinoma and chronic pseudotumoral pancreatitis have similar morphological characteristics in the form of pronounced desmoplastic stromal response and fibrosis-hyalinosis, respectively. The “Time to peak| parameter allowed us to determine statistically significant that pancreatic adenocarcinoma had an early accumulation of contrast agent (average 16 sec) and early washout (from an average of 17 sec); the chronic pseudotumoral pancreatitis had the slow accumulation of contrast agent (average  85 sec) and slow washout (from an average of 86 seconds) (p < 0.05).Conclusion. The “Time to peak” parameter at ultrasound examination with echocontrast allows statistically significantly differentiate adenocarcinoma of the pancreas  and chronic pseudotumoral pancreatitis.  

scholarly journals Quantitative Assessment of Renal Function In Children with UPJO By Contrast-enhanced Ultrasound ： A Pilot Study

2020 ◽  
Author(s):  
Shuofan Chen ◽  
Defu Lin ◽  
Pei Liu ◽  
Ning Sun ◽  
Wenwen Han ◽  
...  
Keyword(s):  
Renal Function ◽  
Roc Curve ◽  
Diagnostic Value ◽  
Control Group ◽  
Intensity Curve ◽  
Time Intensity Curve ◽  
Radioisotope Renography ◽  
Contrast Enhanced ◽  
Perfusion Time ◽  
Experimental Group

Abstract Background: Contrast-enhanced ultrasonography (CEUS) is a new potential modality for the quantitative evaluation of the microvascular perfusion of renal parenchyma.Objective: To prospectively evaluate the diagnostic value of CEUS in assessing renal function in patients with ureteropelvic junction obstruction (UPJO).Methods: The study protocol was approved by the ethics committee of Beijing Children’s Hospital (Beijing,China), and written informed consent was obtained from the patients’ parents or guardians. Ultrasonography (US), CEUS, and radioisotope renography were performed in 51 children (42 boys, 9 girls; mean age, 6.75 ± 4.14 years) with unilateral UPJO. The slope of the ascending curve (A), time to peak (TTP), peak intensity (PI), and area under the curve (AUC) were recorded during CEUS; the quantitative data were calculated by the QLAB system (semiautomated border tracking, Philips Healthcare) software. Sensitivity and specificity values were determined for CEUS and compared with radioisotope renography.Results: A total of 102 kidneys in 51 patients were depicted by CEUS and the perfusion time-intensity curve (TIC).CEUS depicted 102 kidneys in 51 patients, in whom the perfusion time-intensity curve（TIC）was determined. The TIC of renal cortical perfusion in all groups showed an asymmetrical single-peak curve, which could be clearly distinguished between the experimental group and the control group. Compared to the control group, the TTP was markedly prolonged but A was significantly decreased in the experimental group (P < 0.05). There was no significant correlation between AUC, PI and DFR，but the correlation coefficient between TTP, A and DFR remained significant (p<0.001).The receiver operating characteristic （ROC）curve drawn to differentiate the differential renal function (DRF) using the TTP value provided an area under the ROC curve (AUROC) of 0.86. The diagnostic performance of contrast-enhanced US was better than that of US, as the sensitivity and specificity values were 92.86% and 76.14%, respectively.Conclusions: This preliminary experience represents the first report of evaluating the diagnostic value of CEUS in assessing renal function in children with UPJO. CEUS is a highly sensitive, rapid, and diagnostic imaging modality for detecting and monitoring renal function noninvasively.

scholarly journals Conventional, Doppler and Contrast-Enhanced Ultrasonography in Differential Diagnosis of Ovarian Masses

2016 ◽  
Vol 39 (6) ◽  
pp. 2398-2408 ◽  
Author(s):  
Zongyu Liu ◽  
Fan Yang ◽  
Yong Zhang ◽  
Huimei Yu ◽  
He Zhu ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Sensitivity And Specificity ◽  
Malignant Tumors ◽  
Meta Analysis ◽  
Diagnostic Value ◽  
Likelihood Ratios ◽  
Doppler Us ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography ◽  
Ovarian Masses

Background: Differential diagnosis of ovarian masses can influence both treatment selection and prognosis of ovarian tumor patients. A comprehensive review was performed with respect to the diagnostic value of conventional ultrasonography, Doppler ultrasonography and contrast-enhanced ultrasonography (CEUS) in differentiating benign from malignant ovarian masses. Methods: Databases were searched for relevant articles. Retrieved studies were screened according to the inclusion criteria. Pooled statistics including specificity, sensitivity, positive likelihood ratios (PLR), negative likelihood ratios (NLR), diagnostic odds ratio (DOR) and area under curve (AUC) were utilized to calculate the overall diagnostic value for each diagnostic approach. Results: Sixty-seven high quality articles were finally enrolled in the present meta-analysis. The sensitivity and specificity of conventional US were 0.92 and 0.86, respectively. The corresponding sensitivity and specificity of Doppler US were 0.93 and 0.85, respectively. Additionally, these figures for CEUS were 0.97 and 0.92, respectively. Finally, the AUC values for conventional US, Doppler US and CEUS were 0.95, 0.96 and 0.99, respectively. Conclusion: All of the three US-related imaging modalities have relatively high diagnostic value in distinguishing malignant tumors from benign ones in ovarian tumors.

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