Elucidating the Impact of Childhood, Adulthood, and Cumulative Lifetime Trauma Exposure on Psychiatric Symptoms in Early Schizophrenia Spectrum Disorders

2020 ◽  
Author(s):  
Jianlin Liu ◽  
Rathi Mahendran ◽  
Siow Ann Chong ◽  
Mythily Subramaniam
Keyword(s):  
Psychiatric Symptoms ◽  
Trauma Exposure ◽  
Schizophrenia Spectrum Disorders ◽  
Schizophrenia Spectrum ◽  
Lifetime Trauma ◽  
Spectrum Disorders ◽  
The Impact ◽  
Early Schizophrenia

scholarly journals The impact of schizotypy on pragmatics

2020 ◽  
Vol 62 ◽  
pp. e020014
Author(s):  
Monica de Freitas Frias Chaves ◽  
Cilene Rodrigues
Keyword(s):  
Personality Traits ◽  
Contextual Information ◽  
Brazilian Portuguese ◽  
Schizophrenia Spectrum Disorders ◽  
Semantic Meaning ◽  
General Hypothesis ◽  
Schizotypal Personality ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders ◽  
The Impact

High levels of linguistic referential failures are associated with liability to develop schizophrenia-spectrum disorders, and it has been shown that these failures can differentiate healthy subjects, high-schizotypal and schizophrenics groups. Nevertheless, few investigations have focused on whether or not schizotypal traits in nonclinical populations can also impact linguistic reference. In Brazilian Portuguese, only one previous study (acceptability judgements task) had been conducted, and its results suggest association between schizotypal traits and a more rigid preference for assignment of specific readings to definite singular DPs. Here, we present another experimental study in Brazilian Portuguese,  a comprehension task designed to examine possible effects of schizotypal personality traits on the interpretation of definite singular DPs. The findings, in line with the previous results, support the conclusion that schizotypy does affect the interpretation of definite singular DPs in Brazilian Portuguese. Together, these two experiments suggest that schizotypal personality traits impact the integration of linguistic contextual information into the semantic meaning of definite DPs. This is  consistent with the general hypothesis that schizotypy, similarly to schizophrenia, is associated with pragmatic difficulties. Yet, our results emphasize that the impact of schizotypal traits on pragmatics can be observed even in healthy (nonclinical) speakers.

scholarly journals A Randomized Clinical Trial of Oxytocin or Galantamine in Schizophrenia: Assessing the Impact on Behavioral, Lexical, and Self-Report Indicators of Social Affiliation

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Kristen R Dwyer ◽  
Alexandra M Andrea ◽  
Christina L G Savage ◽  
Ryan D Orth ◽  
LeeAnn Shan ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
Controlled Trial ◽  
Self Report ◽  
Schizophrenia Spectrum Disorders ◽  
Social Affiliation ◽  
Subjective Responses ◽  
Randomized Controlled ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders ◽  
The Impact

Abstract Prior studies examining the impact of oxytocin on negative symptoms in schizophrenia have yielded mixed results. The current study explored whether oxytocin can improve more proximal indicators of social affiliation as indicated by changes in behavior, language and subjective indices of social affiliation among individuals with schizophrenia spectrum disorders during a role-play designed to elicit affiliative responses. We tested the hypothesis that daily intranasal oxytocin administered for 6 weeks would improve social affiliation as manifested by increased social skill ratings, use of positive, affiliative, and social words, and subjective responses from a previously published randomized controlled trial. Forty outpatients with schizophrenia or schizoaffective disorder were randomized to the oxytocin, galantamine, or placebo group and completed affiliative role-plays and self-report questionnaires of affect, reactions to the affiliative confederate, and willingness to interact at baseline and post-treatment. Results demonstrated that oxytocin was not effective at improving behavioral or subjective indicators of social affiliation. This study adds to a growing literature that the prosocial effects of oxytocin in schizophrenia are limited or null.

scholarly journals How do ethnicity and deprivation impact on life expectancy at birth in people with serious mental illness? Observational study in the UK

2020 ◽  
pp. 1-9
Author(s):  
Jayati Das-Munshi ◽  
Chin-Kuo Chang ◽  
Alex Dregan ◽  
Stephani L. Hatch ◽  
Craig Morgan ◽  
...  
Keyword(s):  
General Population ◽  
Life Expectancy ◽  
Bipolar Disorders ◽  
Mental Illnesses ◽  
Schizophrenia Spectrum Disorders ◽  
Life Expectancy At Birth ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders ◽  
The Impact ◽  
Deprived Areas

Abstract Background Across international contexts, people with serious mental illnesses (SMI) experience marked reductions in life expectancy at birth. The intersection of ethnicity and social deprivation on life expectancy in SMI is unclear. The aim of this study was to assess the impact of ethnicity and area-level deprivation on life expectancy at birth in SMI, defined as schizophrenia-spectrum disorders, bipolar disorders and depression, using data from London, UK. Methods Abridged life tables to calculate life expectancy at birth, in a cohort with clinician-ascribed ICD-10 schizophrenia-spectrum disorders, bipolar disorders or depression, managed in secondary mental healthcare. Life expectancy in the study population with SMI was compared with life expectancy in the general population and with those residing in the most deprived areas in England. Results Irrespective of ethnicity, people with SMI experienced marked reductions in life expectancy at birth compared with the general population; from 14.5 years loss in men with schizophrenia-spectrum and bipolar disorders, to 13.2 years in women. Similar reductions were noted for people with depression. Across all diagnoses, life expectancy at birth in people with SMI was lower than the general population residing in the most deprived areas in England. Conclusions Irrespective of ethnicity, reductions in life expectancy at birth among people with SMI are worse than the general population residing in the most deprived areas in England. This trend in people with SMI is similar to groups who experience extreme social exclusion and marginalisation. Evidence-based interventions to tackle this mortality gap need to take this into account.

scholarly journals The Role of Dopaminergic Genes in Probabilistic Reinforcement Learning in Schizophrenia Spectrum Disorders

2021 ◽  
Vol 12 (1) ◽  
pp. 7
Author(s):  
Dorota Frydecka ◽  
Błażej Misiak ◽  
Patryk Piotrowski ◽  
Tomasz Bielawski ◽  
Edyta Pawlak ◽  
...  
Keyword(s):  
Reinforcement Learning ◽  
Genetic Polymorphisms ◽  
Schizophrenia Spectrum Disorders ◽  
Schizophrenia Spectrum ◽  
Probabilistic Reinforcement ◽  
Healthy Control ◽  
Spectrum Disorders ◽  
The Impact ◽  
Dopaminergic Genes ◽  
Allele Repeat

Schizophrenia spectrum disorders (SZ) are characterized by impairments in probabilistic reinforcement learning (RL), which is associated with dopaminergic circuitry encompassing the prefrontal cortex and basal ganglia. However, there are no studies examining dopaminergic genes with respect to probabilistic RL in SZ. Thus, the aim of our study was to examine the impact of dopaminergic genes on performance assessed by the Probabilistic Selection Task (PST) in patients with SZ in comparison to healthy control (HC) subjects. In our study, we included 138 SZ patients and 188 HC participants. Genetic analysis was performed with respect to the following genetic polymorphisms: rs4680 in COMT, rs907094 in DARP-32, rs2734839, rs936461, rs1800497, and rs6277 in DRD2, rs747302 and rs1800955 in DRD4 and rs28363170 and rs2975226 in DAT1 genes. The probabilistic RL task was completed by 59 SZ patients and 95 HC subjects. SZ patients performed significantly worse in acquiring reinforcement contingencies during the task in comparison to HCs. We found no significant association between genetic polymorphisms and RL among SZ patients; however, among HC participants with respect to the DAT1 rs28363170 polymorphism, individuals with 10-allele repeat genotypes performed better in comparison to 9-allele repeat carriers. The present study indicates the relevance of the DAT1 rs28363170 polymorphism in RL in HC participants.

scholarly journals EPA guidance on physical activity as a treatment for severe mental illness: a meta-review of the evidence and Position Statement from the European Psychiatric Association (EPA), supported by the International Organization of Physical Therapists in Mental Health (IOPTMH)

2018 ◽  
Vol 54 ◽  
pp. 124-144 ◽  
Author(s):  
Brendon Stubbs ◽  
Davy Vancampfort ◽  
Mats Hallgren ◽  
Joseph Firth ◽  
Nicola Veronese ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bipolar Disorder ◽  
Mental Illness ◽  
Health Outcomes ◽  
Schizophrenia Spectrum Disorders ◽  
Schizophrenia Spectrum ◽  
Meta Review ◽  
Spectrum Disorders ◽  
The Impact

AbstractPhysical activity (PA) may be therapeutic for people with severe mental illness (SMI) who generally have low PA and experience numerous life style-related medical complications. We conducted a meta-review of PA interventions and their impact on health outcomes for people with SMI, including schizophrenia-spectrum disorders, major depressive disorder (MDD) and bipolar disorder. We searched major electronic databases until January 2018 for systematic reviews with/without meta-analysis that investigated PA for any SMI. We rated the quality of studies with the AMSTAR tool, grading the quality of evidence, and identifying gaps, future research needs and clinical practice recommendations. For MDD, consistent evidence indicated that PA can improve depressive symptoms versus control conditions, with effects comparable to those of antidepressants and psychotherapy. PA can also improve cardiorespiratory fitness and quality of life in people with MDD, although the impact on physical health outcomes was limited. There were no differences in adverse events versus control conditions. For MDD, larger effect sizes were seen when PA was delivered at moderate-vigorous intensity and supervised by an exercise specialist. For schizophrenia-spectrum disorders, evidence indicates that aerobic PA can reduce psychiatric symptoms, improves cognition and various subdomains, cardiorespiratory fitness, whilst evidence for the impact on anthropometric measures was inconsistent. There was a paucity of studies investigating PA in bipolar disorder, precluding any definitive recommendations. No cost effectiveness analyses in any SMI condition were identified. We make multiple recommendations to fill existing research gaps and increase the use of PA in routine clinical care aimed at improving psychiatric and medical outcomes.

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