On-line coupling of supercritical fluid extraction and chromatographic techniques

2016 ◽  
Vol 40 (1) ◽  
pp. 213-227 ◽  
Author(s):  
Andrea del Pilar Sánchez-Camargo ◽  
Fabián Parada-Alfonso ◽  
Elena Ibáñez ◽  
Alejandro Cifuentes
1989 ◽  
Vol 477 (1) ◽  
pp. 151-159 ◽  
Author(s):  
D. Thiebaut ◽  
J.-P. Chervet ◽  
R.W. Vannoort ◽  
G.J. De Jong ◽  
U.A.Th. Brinkman ◽  
...  

1990 ◽  
Vol 13 (10) ◽  
pp. 669-673 ◽  
Author(s):  
Robert J. Houben ◽  
Hans-Gerd M. Janssen ◽  
Piet A. Leclercq ◽  
Jacques A. Rijks ◽  
Carel A. Cramers

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Sujuan Pan ◽  
Junbo Zhou ◽  
Haiting Li ◽  
Can Quan

Supercritical fluid extraction and expansion (SFEE) patented technology combines the advantages of both supercritical fluid extraction (SFE) and rapid expansion of supercritical solution (RESS) with on-line coupling, which makes the nanoparticle formation feasible directly from matrix such as Chinese herbal medicine. Supercritical fluid extraction is a green separation technology, which has been developed for decades and widely applied in traditional Chinese medicines or natural active components. In this paper, a SFEE patented instrument was firstly built up and controlled by LABVIEW work stations. Stearic acid was used to verify the SFEE process at optimized condition; via adjusting the preexpansion pressure and temperature one can get different sizes of particles. Furthermore, stearic acid was purified during the SFEE process with HPLC-ELSD detecting device; purity of stearic acid increased by 19%, and the device can purify stearic acid.


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