Enantiopurity analysis of new types of acyclic nucleoside phosphonates by capillary electrophoresis with cyclodextrins as chiral selectors

2013 ◽  
Vol 37 (3) ◽  
pp. 295-303 ◽  
Author(s):  
Veronika Šolínová ◽  
Martin Maxmilián Kaiser ◽  
Miloš Lukáč ◽  
Zlatko Janeba ◽  
Václav Kašička
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Selectors ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside

Acyclic nucleoside phosphonates and human telomerase inhibition

2005 ◽  
Author(s):  
Miroslav Hájek ◽  
Naděžda Matulová ◽  
Ivan Votruba ◽  
Antonín Holý ◽  
Eva Tloušťová
Keyword(s):  
Telomerase Inhibition ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside ◽  
Human Telomerase

Tyrosine-based prodrugs of acyclic nucleoside phosphonates

2014 ◽  
Author(s):  
Tomáš Tichý ◽  
Karel Pomeisl ◽  
Marcela Krečmerová ◽  
Charles E. McKenna
Keyword(s):  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside

Separation of tetrahydrozoline enantiomers in capillary electrophoresis with cyclodextrin-type chiral selectors and investigation of chiral recognition mechanisms

2021 ◽  
Vol 1643 ◽  
pp. 462084
Author(s):  
Ann Gogolashvili ◽  
Ketevan Lomsadze ◽  
Lali Chankvetadze ◽  
Nino Takaishvili ◽  
Paola Peluso ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Recognition ◽  
Chiral Selectors

scholarly journals Comparative analysis of the full set of methylated β‐cyclodextrins as chiral selectors in capillary electrophoresis

2019 ◽  
Vol 40 (21) ◽  
pp. 2789-2798 ◽  
Author(s):  
Erzsébet Varga ◽  
Gábor Benkovics ◽  
András Darcsi ◽  
Bianka Várnai ◽  
Tamás Sohajda ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Comparative Analysis ◽  
Chiral Selectors

scholarly journals Chiral Selectors in Capillary Electrophoresis: Trends During 2017–2018

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1135 ◽  
Author(s):  
Raymond B. Yu ◽  
Joselito P. Quirino
Keyword(s):  
Capillary Electrophoresis ◽  
Molecular Mass ◽  
Chiral Separation ◽  
Chiral Separations ◽  
Water Soluble ◽  
Resonance Spectroscopy ◽  
Electrokinetic Chromatography ◽  
Chiral Selectors ◽  
Analytical Technique ◽  
Pharmaceutical Industries

Chiral separation is an important process in the chemical and pharmaceutical industries. From the analytical chemistry perspective, chiral separation is required for assessing the fit-for-purpose and the safety of chemical products. Capillary electrophoresis, in the electrokinetic chromatography mode is an established analytical technique for chiral separations. A water-soluble chiral selector is typically used. This review therefore examines the use of various chiral selectors in electrokinetic chromatography during 2017–2018. The chiral selectors were both low and high (macromolecules) molecular mass molecules as well as molecular aggregates (supramolecules). There were 58 papers found by search in Scopus, indicating continuous and active activity in this research area. The macromolecules were sugar-, amino acid-, and nucleic acid-based polymers. The supramolecules were bile salt micelles. The low molecular mass selectors were mainly ionic liquids and complexes with a central ion. A majority of the papers were on the use or preparation of sugar-based macromolecules, e.g., native or derivatised cyclodextrins. Studies to explain chiral recognition of macromolecular and supramolecular chiral selectors were mainly done by molecular modelling and nuclear magnetic resonance spectroscopy. Demonstrations were predominantly on drug analysis for the separation of racemates.

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