Purification of transthyretin as nutritional biomarker of selenium status

2012 ◽  
Vol 35 (22) ◽  
pp. 3184-3189 ◽  
Author(s):  
Andrea Mahn ◽  
María Elena Lienqueo ◽  
Claudia Quilodrán ◽  
Alvaro Olivera-Nappa
Keyword(s):  
Selenium Status ◽  
Nutritional Biomarker

Low Selenium Status in the Elderly Influences Thyroid Hormones

1995 ◽  
Vol 89 (6) ◽  
pp. 637-642 ◽  
Author(s):  
Oliviero Olivieri ◽  
Domenico Girelli ◽  
Margherita Azzini ◽  
Anna Maria Stanzial ◽  
Carla Russo ◽  
...  
Keyword(s):  
Glutathione Peroxidase ◽  
Thyroid Hormones ◽  
Peroxidase Activity ◽  
Controlled Trial ◽  
The Elderly ◽  
Serum Selenium ◽  
Selenium Status ◽  
Glutathione Peroxidase Activity ◽  
Double Blind ◽  
Double Blind Placebo

1. Iodothyronine 5′-deiodinase, which is mainly responsible for peripheral triiodothyronine (T3) production, has recently been demonstrated to be a selenium-containing enzyme. In the elderly, reduced peripheral conversion of thyroxine (T4) to T3 and overt hypothyroidism are frequently observed. 2. We measured serum selenium and erythrocyte glutathione peroxidase (as indices of selenium status), thyroid hormones and thyroid-stimulating hormone in 109 healthy euthyroid subjects (52 women, 57 men), carefully selected to exclude abnormally low thyroid hormone levels induced by acute or chronic diseases or calorie restriction. The subjects were subdivided into three age groups. To avoid conditions of undernutrition or malnutrition, dietary records were obtained for a sample of 24 subjects, randomly selected and representative of the whole population for age and sex. 3. In order to properly assess the influence of selenium status on iodothyronine 5′-deiodinase type I activity, a double-blind placebo-controlled trial was also carried out on 36 elderly subjects, resident at a privately owned nursing home. 4. In the free-living population, a progressive reduction of the T3/T4 ratio (due to increased T4 levels) and of selenium and erythrocyte glutathione peroxidase activity was observed with advancing age. A highly significant linear correlation between T4, T3/T4 and selenium was observed in the population as a whole (for T4, R = −0.312, P < 0.002; for T3/T4 ratio, R = 0.32, P < 0.01) and in older subjects (for T4, R = −0.40, P < 0.05; for T3/T4 ratio, R = 0.54, P < 0.002). 5. The main result of the double-blind placebo-controlled trial was a significant improvement of selenium indices and a decrease in the T4 level in selenium-treated subjects; serum selenium, erythrocyte glutathione peroxidase activity and thyroid hormones did not change in placebo-treated subjects. 6. We concluded that selenium status influences thyroid hormones in the elderly, mainly modulating T4 levels.

scholarly journals Selenium and Dogs: A Systematic Review

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 418
Author(s):  
Viola Zentrichová ◽  
Alena Pechová ◽  
Simona Kovaříková
Keyword(s):  
Male Fertility ◽  
Clinical Signs ◽  
Complex Data ◽  
Selenium Status ◽  
Dog Food ◽  
Balanced Diet ◽  
Naturally Occurring ◽  
Correct Function ◽  
Indirect Assay

The intent of this review is to summarize the knowledge about selenium and its function in a dog’s body. For this purpose, systematic literature search was conducted. For mammals, including dogs, a balanced diet and sufficient intake of selenium are important for correct function of metabolism. As for selenium poisoning, there are no naturally occurring cases known. Nowadays, we do not encounter clinical signs of its deficiency either, but it can be subclinical. For now, the most reliable method of assessing selenium status of a dog is measuring serum or plasma levels. Levels in full blood can be measured too, but there are no reference values. The use of glutathione peroxidase as an indirect assay is questionable in canines. Commercial dog food manufactures follow recommendations for minimal and maximal selenium levels and so dogs fed commercial diets should have balanced intake of selenium. For dogs fed home-made diets, complex data are missing. However, subclinical deficiency seems to affect, for example, male fertility or recovery from parasitical diseases. Very interesting is the role of selenium in prevention and treatment of cancer.

scholarly journals The Selenium Status of Dairy Cattle in Estonia

1997 ◽  
Vol 38 (4) ◽  
pp. 353-356
Author(s):  
B. Pehrson ◽  
K. Ling ◽  
K. Ortman
Keyword(s):  
Dairy Cattle ◽  
Selenium Status

scholarly journals Environmental and human iodine and selenium status: lessons from Gilgit-Baltistan, North-East Pakistan

2021 ◽  
Author(s):  
Saeed Ahmad ◽  
Elizabeth H. Bailey ◽  
Muhammad Arshad ◽  
Sher Ahmed ◽  
Michael J. Watts ◽  
...  
Keyword(s):  
Drinking Water ◽  
Specific Gravity ◽  
Salt Intake ◽  
Daily Intake ◽  
Urinary Iodine ◽  
Selenium Status ◽  
Environmental Standards ◽  
Iodised Salt ◽  
North East ◽  
Gilgit Baltistan

AbstractIodine and selenium deficiencies are common worldwide. We assessed the iodine and selenium status of Gilgit-Baltistan, Pakistan. We determined the elemental composition (ICP-MS) of locally grown crops (n = 281), drinking water (n = 82), urine (n = 451) and salt (n = 76), correcting urinary analytes for hydration (creatinine, specific gravity). We estimated dietary iodine, selenium and salt intake. Median iodine and selenium concentrations were 11.5 (IQR 6.01, 23.2) and 8.81 (IQR 4.03, 27.6) µg/kg in crops and 0.24 (IQR 0.12, 0.72) and 0.27 (IQR 0.11, 0.46) µg/L in water, respectively. Median iodised salt iodine was 4.16 (IQR 2.99, 10.8) mg/kg. Population mean salt intake was 13.0 g/day. Population median urinary iodine (uncorrected 78 µg/L, specific gravity-corrected 83 µg/L) was below WHO guidelines; creatinine-corrected median was 114 µg/L but was unreliable. Daily selenium intake (from urinary selenium concentration) was below the EAR in the majority (46–90%) of individuals. Iodine and selenium concentrations in all crops were low, but no health-related environmental standards exist. Iodine concentration in iodised salt was below WHO-recommended minimum. Estimated population average salt intake was above WHO-recommended daily intake. Locally available food and drinking water together provide an estimated 49% and 72% of EAR for iodine (95 µg/day) and selenium (45 µg/day), respectively. Low environmental and dietary iodine and selenium place Gilgit-Baltistan residents at risk of iodine deficiency disorders despite using iodised salt. Specific gravity correction of urine analysis for hydration is more consistent than using creatinine. Health-relevant environmental standards for iodine and selenium are needed.

Selenium status of term infants fed human milk or selenite-supplemented soy formula

1993 ◽  
Vol 122 (5) ◽  
pp. 739-741 ◽  
Author(s):  
Carolyn E. Johnson ◽  
Anne M. Smith ◽  
Gary M. Chan ◽  
Laurie J. Moyer-Mileur
Keyword(s):  
Human Milk ◽  
Selenium Status ◽  
Term Infants

Selenium status parameters in patients with polycystic ovary syndrome

2017 ◽  
Vol 44 ◽  
pp. 241-246 ◽  
Author(s):  
P. Zagrodzki ◽  
M. Krzyczkowska-Sendrakowska ◽  
F. Nicol ◽  
R. Wietecha-Posłuszny ◽  
T. Milewicz ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Selenium Status ◽  
Ovary Syndrome

scholarly journals Selenium status in term and preterm infants during the first months of life

2007 ◽  
Vol 62 (3) ◽  
pp. 349-355 ◽  
Author(s):  
A Loui ◽  
A Raab ◽  
P Braetter ◽  
M Obladen ◽  
V N de Braetter
Keyword(s):  
Preterm Infants ◽  
Selenium Status
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