Preparation of molecularly imprinted polymer by surface imprinting technique and its performance for adsorption of dibenzothiophene

2011 ◽  
Vol 34 (14) ◽  
pp. 1746-1753 ◽  
Author(s):  
Wan-Zhen Xu ◽  
Wei Zhou ◽  
Li-Hua Bian ◽  
Wei-Hong Huang ◽  
Xiang-Yang Wu
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Surface Imprinting ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Surface Imprinting Technique

A novel molecularly imprinted polymer thin film at surface of ZnO nanorods for selective fluorescence detection of para-nitrophenol

RSC Advances ◽  
2015 ◽  
Vol 5 (55) ◽  
pp. 44088-44095 ◽  
Author(s):  
Xiao Wei ◽  
Zhiping Zhou ◽  
Tongfan Hao ◽  
Hongji Li ◽  
Yanzhuo Zhu ◽  
...  
Keyword(s):  
Thin Film ◽  
Molecular Recognition ◽  
Fluorescence Detection ◽  
Molecularly Imprinted Polymer ◽  
Zno Nanorods ◽  
Surface Imprinting ◽  
Imprinted Polymer ◽  
Polymer Thin Film ◽  
Molecularly Imprinted ◽  
Recognition Ability

A novel MIPs-based ZnO nanorods with molecular recognition ability for para-nitrophenol was successfully synthesized via a surface imprinting-directing polymerization.

Liquid Chromatography Analysis of Clozapine in Rat Brain Tissue, Using its Molecularly Imprinted Polymer after Administration of Toxic Dose of Drug and Lipid Emulsion Therapy

2019 ◽  
Vol 15 (3) ◽  
pp. 251-257
Author(s):  
Bahareh Sadat Yousefsani ◽  
Seyed Ahmad Mohajeri ◽  
Mohammad Moshiri ◽  
Hossein Hosseinzadeh
Keyword(s):  
Rat Brain ◽  
Brain Tissue ◽  
Molecularly Imprinted Polymer ◽  
Lipid Emulsion ◽  
Limit Of Detection ◽  
Imprinted Polymer ◽  
Toxic Dose ◽  
Molecularly Imprinted ◽  
The Brain ◽  
Rat Brain Tissue

Background:Molecularly imprinted polymers (MIPs) are synthetic polymers that have a selective site for a given analyte, or a group of structurally related compounds, that make them ideal polymers to be used in separation processes.Objective:An optimized molecularly imprinted polymer was selected and applied for selective extraction and analysis of clozapine in rat brain tissue.Methods:A molecularly imprinted solid-phase extraction (MISPE) method was developed for preconcentration and cleanup of clozapine in rat brain samples before HPLC-UV analysis. The extraction and analytical process was calibrated in the range of 0.025-100 ppm. Clozapine recovery in this MISPE process was calculated between 99.40 and 102.96%. The limit of detection (LOD) and the limit of quantification (LOQ) of the assay were 0.003 and 0.025 ppm, respectively. Intra-day precision values for clozapine concentrations of 0.125 and 0.025 ppm were 5.30 and 3.55%, whereas inter-day precision values of these concentrations were 9.23 and 6.15%, respectively. In this study, the effect of lipid emulsion infusion in reducing the brain concentration of drug was also evaluated.Results:The data indicated that calibrated method was successfully applied for the analysis of clozapine in the real rat brain samples after administration of a toxic dose to animal. Finally, the efficacy of lipid emulsion therapy in reducing the brain tissue concentration of clozapine after toxic administration of drug was determined.Conclusion:The proposed MISPE method could be applied in the extraction and preconcentration before HPLC-UV analysis of clozapine in rat brain tissue.

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