Chiral HPLC separation and absolute configuration assignment of a series of new triazole compounds

2011 ◽  
Vol 34 (4) ◽  
pp. 363-370 ◽  
Author(s):  
Chunguang Lv ◽  
Zhiqiang Zhou
Keyword(s):  
Absolute Configuration ◽  
Chiral Hplc ◽  
Hplc Separation ◽  
Configuration Assignment

Chiral HPLC separation and absolute configuration of novelS-DABO derivatives

Chirality ◽  
2009 ◽  
Vol 21 (6) ◽  
pp. 604-612 ◽  
Author(s):  
Roberto Cirilli ◽  
Rosella Ferretti ◽  
Francesco La Torre ◽  
Anna Borioni ◽  
Vincenzo Fares ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Chiral Hplc ◽  
Hplc Separation

Comparison of (R)-(-)-6,6'-Bis(3,5-dinitrobenzamido)biphenyl-2,2'-dicarboxylic and (S)-(+)-6,6'-Bis-(3,5-dinitrobenzamidomethyl)biphenyl-2,2'-dicarboxylic Acids as Chiral HPLC Selectors

1997 ◽  
Vol 62 (1) ◽  
pp. 62-68 ◽  
Author(s):  
Miloš Tichý ◽  
Luděk Ridvan ◽  
Jiří Závada
Keyword(s):  
Absolute Configuration ◽  
Dicarboxylic Acids ◽  
Optically Active ◽  
Chiral Hplc ◽  
Hplc Separation ◽  
Separation Of Enantiomers ◽  
Standard Set ◽  
Biaryl Compounds

The title optically active diacids (R)-I and (S)-II of known absolute configuration were investigated as selectors in HPLC separation of enantiomers. With a standard set of benzamido alcohols and biaryl compounds, the separation was less efficient and less general than that found for selectors based on studied previously.

Synthesis, Chiral Separation, Absolute Configuration Assignment, and Biological Activity of Enantiomers of Retro-1 as Potent Inhibitors of Shiga Toxin

ChemMedChem ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. 1153-1156 ◽  
Author(s):  
Hajer Abdelkafi ◽  
Aurélien Michau ◽  
Alexandra Clerget ◽  
David-Alexandre Buisson ◽  
Ludger Johannes ◽  
...  
Keyword(s):  
Biological Activity ◽  
Absolute Configuration ◽  
Chiral Separation ◽  
Shiga Toxin ◽  
Configuration Assignment

scholarly journals Absolute Configuration Sensing of Chiral Aryl- and Aryloxy-Propionic Acids by Biphenyl Chiroptical Probes

Chemosensors ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 154
Author(s):  
Stefania Vergura ◽  
Stefano Orlando ◽  
Patrizia Scafato ◽  
Sandra Belviso ◽  
Stefano Superchi
Keyword(s):  
Circular Dichroism ◽  
Absolute Configuration ◽  
Optical Rotation ◽  
Environmental Pollutants ◽  
Red Shift ◽  
Electronic Circular Dichroism ◽  
Configuration Assignment ◽  
Clear Sign ◽  
The Absolute ◽  
Circular Dichroïsm

The absolute configuration of chiral 2-aryl and 2-aryloxy propionic acids, which are among the most common chiral environmental pollutants, has been readily and reliably established by either electronic circular dichroism spectroscopy or optical rotation measurements employing suitably designed 4,4′-disubstituted biphenyl probes. In fact, the 4,4′-biphenyl substitution gives rise to a red shift of the diagnostic electronic circular dichroism signal of the biphenyl A band employed for the configuration assignment, removing its overlap with other interfering dichroic bands and allowing its clear sign identification. The largest A band red shift, and thus the most reliable results, are obtained by employing as a probe the 4,4′-dinitro substituted biphenylazepine 3c. The method was applied to the absolute configuration assignment of 2-arylpropionic acids ibuprofen (1a), naproxen (1b), ketoprofen (1c) and flurbiprofen (1d), as well as to the 2-aryloxypropionic acids 2-phenoxypropionic acid (2a) and 2-naphthoxypropionic acid (2b). This approach, allowing us to reveal the sample’s absolute configuration by simple optical rotation measurements, is potentially applicable to online analyses of both the enantiomeric composition and absolute configuration of these chiral pollutants.

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