A sensitive column-switching HPLC method for aripiprazole and dehydroaripiprazole and its application to human pharmacokinetic studies

2010 ◽  
Vol 33 (21) ◽  
pp. 3292-3298 ◽  
Author(s):  
Yumiko Akamine ◽  
Norio Yasui-Furukori ◽  
Midori Kojima ◽  
Yoshimasa Inoue ◽  
Tsukasa Uno
Keyword(s):  
Column Switching ◽  
Hplc Method ◽  
Pharmacokinetic Studies ◽  
Human Pharmacokinetic

scholarly journals Antimicrobial Activity of Non-steroidal Anti-inflammatory Drugs on Biofilm: Current Evidence and Potential for Drug Repurposing

2021 ◽  
Vol 12 ◽  
Author(s):  
Rodrigo Cuiabano Paes Leme ◽  
Raquel Bandeira da Silva
Keyword(s):  
Bacterial Species ◽  
Drug Repurposing ◽  
Current Evidence ◽  
Pharmacokinetic Studies ◽  
Bacterial Populations ◽  
Human Pharmacokinetic ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

It has been demonstrated that some non-steroidal anti-inflammatory drugs (NSAIDs), like acetylsalicylic acid, diclofenac, and ibuprofen, have anti-biofilm activity in concentrations found in human pharmacokinetic studies, which could fuel an interest in repurposing these well tolerated drugs as adjunctive therapies for biofilm-related infections. Here we sought to review the currently available data on the anti-biofilm activity of NSAIDs and its relevance in a clinical context. We performed a systematic literature review to identify the most commonly tested NSAIDs drugs in the last 5 years, the bacterial species that have demonstrated to be responsive to their actions, and the emergence of resistance to these molecules. We found that most studies investigating NSAIDs’ activity against biofilms were in vitro, and frequently tested non-clinical bacterial isolates, which may not adequately represent the bacterial populations that cause clinically-relevant biofilm-related infections. Furthermore, studies concerning NSAIDs and antibiotic resistance are scarce, with divergent outcomes. Although the potential to use NSAIDs to control biofilm-related infections seems to be an exciting avenue, there is a paucity of studies that tested these drugs using appropriate in vivo models of biofilm infections or in controlled human clinical trials to support their repurposing as anti-biofilm agents.

HPLC method for the determination and pharmacokinetic studies of four triterpenoids in rat plasma after oral administration ofGanoderma lucidum extract

2007 ◽  
Vol 21 (4) ◽  
pp. 389-396 ◽  
Author(s):  
Xiaoming Wang ◽  
Rongxia Liu ◽  
Jianghao Sun ◽  
Shuhong Guan ◽  
Min Yang ◽  
...  
Keyword(s):  
Oral Administration ◽  
Rat Plasma ◽  
Hplc Method ◽  
Pharmacokinetic Studies

scholarly journals HPLC determination of ketamine, norketamine, and dehydronorketamine in plasma with a high-purity reversed-phase sorbent

1998 ◽  
Vol 44 (3) ◽  
pp. 560-564 ◽  
Author(s):  
Sébastien Bolze ◽  
Roselyne Boulieu
Keyword(s):  
Low Dose ◽  
Reversed Phase ◽  
Hplc Method ◽  
Pharmacokinetic Studies ◽  
Liquid Liquid Extraction ◽  
Extraction Separation ◽  
Acetate Mixture ◽  
New Stationary Phase ◽  
High Column

Abstract We developed an isocratic, selective, and very sensitive HPLC method for the determination of ketamine and its two main metabolites in plasma. The compounds were extracted from plasma by a liquid–liquid extraction with a dichloromethane:ethyl acetate mixture followed by an acidic back-extraction. Separation was achieved on a new stationary phase, Purospher RP-18 end-capped, with a mobile phase containing acetonitrile:0.03 mol/L phosphate buffer (23:77 by vol) adjusted to pH 7.2. Because of the high column efficiency and the significant improvement of peak symmetry, the quantification limit could be down to 5 μg/L for ketamine and norketamine (NK). The intraday and interday CVs ranged from 1.7% to 5.8% and 3.1% to 10.2% for all compounds respectively. The method is sensitive enough for monitoring ketamine, NK, and dehydroketamine in plasma during pharmacokinetic studies after an intravenous bolus of a low dose of ketamine.

scholarly journals Highly Bioavailable Forms of Curcumin and Promising Avenues for Curcumin-Based Research and Application: A Review

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1397 ◽  
Author(s):  
Sidney J. Stohs ◽  
Oliver Chen ◽  
Sidhartha D. Ray ◽  
Jin Ji ◽  
Luke R. Bucci ◽  
...  
Keyword(s):  
Free Form ◽  
Blood Levels ◽  
Pharmacokinetic Studies ◽  
Protective Effects ◽  
Health Maintenance ◽  
Enhanced Absorption ◽  
Wide Range ◽  
Human Pharmacokinetic ◽  
Potential Applications ◽  
Health Promoting

Curcumin exerts a wide range of beneficial physiological and pharmacological activities, including antioxidant, anti-amyloid, anti-inflammatory, anti-microbial, anti-neoplastic, immune-modulating, metabolism regulating, anti-depressant, neuroprotective and tissue protective effects. However, its poor solubility and poor absorption in the free form in the gastrointestinal tract and its rapid biotransformation to inactive metabolites greatly limit its utility as a health-promoting agent and dietary supplement. Recent advances in micro- and nano-formulations of curcumin with greatly enhanced absorption resulting in desirable blood levels of the active forms of curcumin now make it possible to address a wide range of potential applications, including pain management, and as tissue protective. Using these forms of highly bioavailable curcumin now enable a broad spectrum of appropriate studies to be conducted. This review discusses the formulations designed to enhance bioavailability, metabolism of curcumin, relationships between solubility and particle size relative to bioavailability, human pharmacokinetic studies involving formulated curcumin products, the widely used but inappropriate practice of hydrolyzing plasma samples for quantification of blood curcumin, current applications of curcumin and its metabolites and promising directions for health maintenance and applications.

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