Protein adsorption in porous adsorbent particles: A multiscale modeling study on inner radial humps in the concentration profiles of adsorbed protein induced by nonuniform ligand density distributions

2009 ◽  
Vol 32 (18) ◽  
pp. 3084-3098 ◽  
Author(s):  
Enrico Riccardi ◽  
Jee-Ching Wang ◽  
Athanasios I. Liapis
Keyword(s):  
Protein Adsorption ◽  
Multiscale Modeling ◽  
Concentration Profiles ◽  
Ligand Density ◽  
Density Distributions ◽  
Adsorbed Protein ◽  
Porous Adsorbent ◽  
Modeling Study

A look into the interaction of metal oxide thin films with biological media: Albumin and Fibrinogen adsorption

2012 ◽  
Vol 1376 ◽  
Author(s):  
P. Silva-Bermudez ◽  
S. Muhl ◽  
M. Rivera ◽  
S. E. Rodil
Keyword(s):  
Surface Roughness ◽  
Surface Energy ◽  
Protein Adsorption ◽  
Photoelectron Spectroscopy ◽  
Ex Situ ◽  
Polar Component ◽  
Metal Oxide Thin Films ◽  
Adsorbed Protein ◽  
Major Chemical ◽  
Fibrinogen Adsorption

ABSTRACTIn the present work, the adsorption of albumin and fibrinogen on Ta, Nb, Ti and Zr oxidesthin films deposited on Si (100) wafers by magnetron sputtering was studied in order to get a better understanding of the correlation among the surface properties of these oxides and the protein adsorption phenomena on their surfaces. The surface energy, hydrophobicity, chemical composition, roughness and atomic order of the films were characterized. The films were immersedfor 45 minutes in single protein solutions; either albumin or fibrinogenand the adsorbed protein layer on the films was studied ex-situ in a dry ambient using bothX-ray photoelectron spectroscopy and atomic force microscopy.The adsorption of albumin and fibrinogen on the films modified the surface morphology and decreased the surface roughness for all the four different metal oxides. The XPS results confirmed the presence of the protein on the surface of the films and showed that the two proteins studied were adsorbed without undergoing a major chemical decomposition. A correlation between the surface roughness,the polar component of the surface energy of the films and the atomic percentage of nitrogen on the films after protein adsorption, an indirect signal of the amount of protein adsorbed, was found for albumin and fibrinogen adsorption on Ta, Nb and Ti oxides; the largest the roughness or the polar component the largest amount of adsorbed protein.

scholarly journals Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation—An Integrated Multiscale Modeling Study

2016 ◽  
Vol 120 (33) ◽  
pp. 8264-8275 ◽  
Author(s):  
Sukriti Dewan ◽  
Kimberly J. McCabe ◽  
Michael Regnier ◽  
Andrew D. McCulloch ◽  
Steffen Lindert
Keyword(s):  
Multiscale Modeling ◽  
Calcium Sensitivity ◽  
Myofilament Activation ◽  
Molecular Effects ◽  
Modeling Study

Multiscale modeling study of pulsed damage accumulation in α-Fe under inertial fusion conditions

2002 ◽  
Vol 307-311 ◽  
pp. 907-911 ◽  
Author(s):  
J.M. Perlado ◽  
D. Lodi ◽  
E. Domı́nguez ◽  
J. Prieto ◽  
M.J. Caturla ◽  
...  
Keyword(s):  
Multiscale Modeling ◽  
Damage Accumulation ◽  
Inertial Fusion ◽  
Modeling Study

scholarly journals Probing Protein Aggregation at Buried Interfaces: Distinguishing Adsorbed Protein Monomer, Dimer, and Monomer-Dimer Mixture in Situ

2022 ◽  
Author(s):  
Tieyi Lu ◽  
Wen Guo ◽  
Datar M. Prathamesh ◽  
Yue Xin ◽  
E. Neil G. Marsh ◽  
...  
Keyword(s):  
Protein Aggregation ◽  
Protein Adsorption ◽  
Protein Drug ◽  
Protein Drugs ◽  
Biomedical Materials ◽  
Drug Adsorption ◽  
Separation Membranes ◽  
Buried Interfaces ◽  
Adsorbed Protein

Protein adsorption on surfaces greatly impacts many applications such as biomedical materials, anti-biofouling coatings, bio-separation membranes, biosensors, and antibody protein drugs etc. For example, protein drug adsorption on widely used...

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