Extended thermodynamic approach to ion interaction chromatography. Influence of the chain length of the solute ion: a chromatographic method for the determination of ion-pairing constants

2005 ◽  
Vol 28 (6) ◽  
pp. 549-554 ◽  
Author(s):  
Teresa Cecchi
Keyword(s):  
Chain Length ◽  
Chromatographic Method ◽  
Ion Pairing ◽  
Thermodynamic Approach ◽  
Extended Thermodynamic

Determination of Procaine and Related Local Anesthetics. II. Collaborative Study

1975 ◽  
Vol 58 (1) ◽  
pp. 93-94
Author(s):  
Joseph B Proctor ◽  
Thomas D Doyle
Keyword(s):  
Spectrophotometric Determination ◽  
Local Anesthetics ◽  
Active Component ◽  
Chromatographic Method ◽  
Collaborative Study ◽  
Ion Pairing ◽  
The Other ◽  
Three Solutions ◽  
Average Recovery

Abstract The ion-pairing chromatographic method reported previously for the isolation and spectrophotometric determination of the local anesthetics, alone and in combination, was studied collaboratively. Three solutions were assayed. One containing procaine as the single active component gave an average recovery of 99.8± 1.7%. A mixture of procaine and tetracaine gave results of 99.3±1.6 and 98.9±8.82%, respectively. A third solution containing procaine and propoxycaine assayed 100.0±1.5 and 99.1±1.9%, respectively. It was shown that low results for tetracaine were due to loss during the final evaporative step. The method for samples containing tetracaine should be studied further. The other methods have been adopted as official first action.

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