Liquid-phase microextraction of basic drugs - Selection of extraction mode based on computer calculated solubility data

2005 ◽  
Vol 28 (11) ◽  
pp. 1195-1203 ◽  
Author(s):  
Stig Pedersen-Bjergaard ◽  
Knut Einar Rasmussen ◽  
Anders Brekke ◽  
Tung Si Ho ◽  
Trine Grønhaug Halvorsen
Keyword(s):  
Liquid Phase ◽  
Solubility Data ◽  
Basic Drugs ◽  
Liquid Phase Microextraction ◽  
Calculated Solubility ◽  
Selection Of

Effect of type of stirring on hollow fiber liquid phase microextraction and electromembrane extraction of basic drugs: speed up extraction time and enhancement of extraction efficiency

RSC Advances ◽  
2016 ◽  
Vol 6 (111) ◽  
pp. 110221-110228 ◽  
Author(s):  
Saeed Nojavan ◽  
Zeinab Tahmasebi ◽  
Saied Saeed Hosseiny Davarani
Keyword(s):  
Liquid Phase ◽  
Hollow Fiber ◽  
Extraction Efficiency ◽  
Extraction Time ◽  
Basic Drugs ◽  
Liquid Phase Microextraction ◽  
Speed Up ◽  
Electromembrane Extraction

In microextraction procedures, the stirring of the donor solution is crucial to speed up the extraction.

Multi-walled Carbon Nanotubes Reinforced into Hollow Fiber by Chitosan Sol-gel for Solid/Liquid Phase Microextraction of NSAIDs from Urine Prior to HPLC-DAD Analysis

2019 ◽  
Vol 20 (5) ◽  
pp. 390-400 ◽  
Author(s):  
Nabil N. AL-Hashimi ◽  
Amjad H. El-Sheikh ◽  
Rania F. Qawariq ◽  
Majed H. Shtaiwi ◽  
Rowan AlEjielat
Keyword(s):  
Carbon Nanotubes ◽  
Liquid Phase ◽  
Hollow Fiber ◽  
Sol Gel ◽  
Liquid Phase Microextraction ◽  
Extraction Device ◽  
Multi Walled Carbon Nanotubes ◽  
Solid Liquid ◽  
Walled Carbon Nanotubes

Background: The efficient analytical method for the analysis of nonsteroidal antiinflammatory drugs (NSAIDs) in a biological fluid is important for determining the toxicological aspects of such long-term used therapies. Methods: In the present work, multi-walled carbon nanotubes reinforced into a hollow fiber by chitosan sol-gel assisted-solid/ liquid phase microextraction (MWCNTs-HF-CA-SPME) method followed by the high-performance liquid chromatography-diode array detection (HPLC–DAD) was developed for the determination of three NSAIDs, ketoprofen, diclofenac, and ibuprofen in human urine samples. MWCNTs with various dimensions were characterized by various analytical techniques. The extraction device was prepared by immobilizing the MWCNTs in the pores of 2.5 cm microtube via chitosan sol-gel assisted technology while the lumen of the microtube was filled with few microliters of 1-octanol with two ends sealed. The extraction device was operated by direct immersion in the sample solution. Results: The main factors influencing the extraction efficiency of the selected NSAIDs have been examined. The method showed good linearity R2 ≥ 0.997 with RSDs from 1.1 to 12.3%. The limits of detection (LODs) were 2.633, 2.035 and 2.386 µg L-1, for ketoprofen, diclofenac, and ibuprofen, respectively. The developed method demonstrated a satisfactory result for the determination of selected drugs in patient urine samples and comparable results against reference methods. Conclusion: The method is simple, sensitive and can be considered as an alternative for clinical laboratory analysis of selected drugs.

Sign in / Sign up

Export Citation Format

Share Document