Polypeptide growth factors: Some structural and mechanistic considerations

1980 ◽  
Vol 14 (2) ◽  
pp. 183-199 ◽  
Author(s):  
Ralph A. Bradshaw ◽  
Jeffrey S. Rubin
Keyword(s):  
Growth Factors ◽  
Polypeptide Growth Factors

Growth factors and metanephrogenesis

1992 ◽  
Vol 262 (4) ◽  
pp. F523-F532 ◽  
Author(s):  
M. R. Hammerman ◽  
S. A. Rogers ◽  
G. Ryan
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Kidney Development ◽  
Transforming Growth Factor ◽  
Polypeptide Growth Factors ◽  
Metanephric Kidney ◽  
Epidermal Growth ◽  
Factor Alpha ◽  
Editorial Review

The formation of all organs during embryogenesis, including kidney, is dependent on the timed and sequential expression of a number of polypeptide growth factors. Synthesis and actions of one or more members of the insulin-like growth factor, epidermal growth factor/transforming growth factor-alpha, transforming growth factor-beta, platelet-derived growth factor, fibroblast growth factor, and nerve growth factor families have been characterized in the developing metanephric kidney. Studies originating from a number of laboratories have defined the localization of growth factor mRNAs, receptors and peptides, have delineated patterns of growth factor synthesis, and have established the growth factor dependency of embryonic kidney development. The results of these investigations will be summarized in this editorial review and integrated within the broader context of growth factor cellular physiology and growth factor expression in nonrenal systems.

Restricted expression of the hyaluronan receptor, CD44, during postimplantation mouse embryogenesis suggests key roles in tissue formation and patterning

Development ◽  
1993 ◽  
Vol 119 (2) ◽  
pp. 295-306 ◽  
Author(s):  
S.C. Wheatley ◽  
C.M. Isacke ◽  
P.H. Crossley
Keyword(s):  
Growth Factors ◽  
Cell Attachment ◽  
Mesenchymal Cell ◽  
Limb Bud ◽  
Temporal And Spatial Distribution ◽  
Mouse Embryogenesis ◽  
Cd44 Isoforms ◽  
Adhesion Protein ◽  
Polypeptide Growth Factors ◽  
Cell Matrix Interactions

CD44 is a multifunctional adhesion protein that acts as a major receptor for the hygroscopic extracellular matrix component, hyaluronan. This receptor-ligand binding directly mediates at least some of the cell-cell and cell-matrix interactions ascribed to CD44. Other interactions involving CD44 may be modulated indirectly by its ability to bind growth factors and thereby to promote cell attachment. During vertebrate development, multiple cases of hyaluronan involvement in cell proliferation, cell migration and histogenesis have been documented. In addition, there is evidence suggesting a central role for cell surface glycoproteins and proteoglycans in mediating the action of polypeptide growth factors involved in tissue patterning. In view of this, we undertook to investigate expression of the CD44 protein during postimplantation mouse embryogenesis. Between 9.5 and 12.5 days of embryonic development, the predominant form of CD44 protein corresponds to the hyaluronan-binding CD44H form. However, species with a higher M(r) were also detected, implying that CD44 isoforms generated by alternative splicing of CD44 RNA are employed in normal development. Further, we used mouse embryos to perform whole-mount immunohistochemistry and examine the temporal and spatial distribution of this glycoprotein. CD44 is expressed at high levels in the heart, somites and condensing limb-bud mesenchyme at critical stages of morphogenesis. These sites correlate with regions where hyaluronan has been demonstrated to regulate morphogenetic events. Of novel interest, however, is the high expression of CD44 in regions that do not correlate with sites of known hyaluronan-mediated developmental events. These include instructive epithelia participating in epithelial-mesenchymal cell interactions such as the apical ectodermal ridge of the developing limb bud and the odontogenic placodes of the presumptive upper and lower jaws.

Secretion of Polypeptide Growth Factors by Human Nonfunctioning Pituitary Adenoma Cells in Culture

1993 ◽  
Vol 57 (5) ◽  
pp. 825-834 ◽  
Author(s):  
Ulrich Renner ◽  
Juri Mojto ◽  
Eduardo Arzt ◽  
Manfred Lange ◽  
Johanna Stalla ◽  
...  
Keyword(s):  
Growth Factors ◽  
Pituitary Adenoma ◽  
Nonfunctioning Pituitary Adenoma ◽  
Cells In Culture ◽  
Polypeptide Growth Factors
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