Stimulation of human vascular endothelial cell growth by a platelet-derived growth factor and thrombin

1979 ◽  
Vol 11 (3) ◽  
pp. 361-370 ◽  
Author(s):  
Bruce R. Zetter ◽  
Harry N. Antoniades
Keyword(s):  
Endothelial Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Vascular Endothelial Cell ◽  
Platelet Derived Growth Factor ◽  
Vascular Endothelial ◽  
Human Vascular Endothelial Cell ◽  
Endothelial Cell Growth ◽  
Stimulation Of

scholarly journals Vascular Endothelial Cell Growth Factor A Acts via Platelet-Derived Growth Factor Receptor α To Promote Viability of Cells Enduring Hypoxia

2016 ◽  
Vol 36 (18) ◽  
pp. 2314-2327 ◽  
Author(s):  
Steven Pennock ◽  
Leo A. Kim ◽  
Andrius Kazlauskas
Keyword(s):  
Endothelial Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Vascular Endothelial Cell ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Vegf Receptor ◽  
Vascular Endothelial ◽  
Endothelial Cell Growth Factor ◽  
Endothelial Cell Growth

Vascular endothelial cell growth factor A (VEGF) is a biologically and therapeutically important growth factor because it promotes angiogenesis in response to hypoxia, which underlies a wide variety of both physiological and pathological settings. We report here that both VEGF receptor 2 (VEGFR2)-positive and -negative cells depended on VEGF to endure hypoxia. VEGF enhanced the viability of platelet-derived growth factor receptor α (PDGFRα)-positive and VEGFR2-negative cells by enabling indirect activation of PDGFRα, thereby reducing the level of p53. We conclude that the breadth of VEGF's influence extends beyond VEGFR-positive cells and propose a plausible mechanistic explanation of this phenomenon.

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