scholarly journals Analysis of cell‐free circulating DNA fragment size and level in patients with lumbar canal stenosis

JOR Spine ◽  
2021 ◽  
Author(s):  
Akihiko Hiyama ◽  
Daisuke Sakai ◽  
Satoshi Nomura ◽  
Hiroyuki Katoh ◽  
Masahiko Watanabe
Keyword(s):  
Fragment Size ◽  
Circulating Dna ◽  
Lumbar Canal Stenosis ◽  
Canal Stenosis ◽  
Dna Fragment ◽  
Free Circulating Dna

scholarly journals Analysis of Cell-free Circulating DNA Fragment Size and Level in Patients With Lumbar Degenerative Disease

2021 ◽  
Author(s):  
Akihiko Hiyama ◽  
Daisuke Sakai ◽  
Satoshi Nomura ◽  
Hiroyuki Katoh ◽  
Masahiko Watanabe
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Fragment Size ◽  
Degenerative Disease ◽  
Control Group ◽  
Circulating Dna ◽  
Healthy Controls ◽  
Low Back ◽  
Lumbar Degenerative Disease ◽  
Free Circulating Dna

Abstract Background: Cell-free circulating DNA (cfDNA), which can be extracted by liquid biopsy, has been studied as a noninvasive biomarker for various diseases. The potential of cfDNA fragment size and level as a marker for low back pain (LBP) has never been studied. We investigated whether cfDNA is a biomarker of LBP severity in patients with a lumbar degenerative disease (LDD). Methods: Blood samples were obtained from patients with LDD (n = 21) before and immediately after spinal surgery. Plasma DNA was isolated and examined for cfDNA fragment size and concentration. A cohort of healthy volunteers (n = 5) constituted the control group.Results: The cfDNA fragment size tended to be shorter in patients than in healthy controls, but this difference was not significant (P = .224). cfDNA level was significantly higher in LDD patients (mean 0.642±0.199 ng/mL, range 0.302–1.150 ng/mL) than in healthy controls (mean 0.429±0.064 ng/mL, range 0.366–0.506 ng/mL) (P = .029). cfDNA level correlated positively with present pain (r = .421, P = .036), maximum pain (r = .419, P = .037), average pain (r = .566, P = .003), low back pain (r = .403, P = .041), leg pain (r = .480, P = .013), and leg numbness (r = .455, P = .020). cfDNA fragment size did not differ from before to after surgery, but cfDNA level increased postoperatively in patients with LDD. Conclusions: This was the first study investigating whether cfDNA fragment size and level are associated with pain, including LBP, in patients with LDD. Our findings suggest that cfDNA level may be an objective indicator of pain and surgical invasiveness in patients with LDD.

scholarly journals The value of cervical MRI in surgical lumbar canal stenosis patients

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Omar Youssef Abdalla ◽  
Hieder Al-Shami ◽  
Heba Medhat Maghraby ◽  
Abdelrhman Enayet
Keyword(s):  
Clinical Presentation ◽  
Adult Population ◽  
Cervical Canal ◽  
Lumbar Stenosis ◽  
Cervical Stenosis ◽  
Lumbar Canal Stenosis ◽  
Cervical Canal Stenosis ◽  
Canal Stenosis ◽  
Tandem Spinal Stenosis ◽  
A Prospective Study

Abstract Background The prevalence of cervical canal stenosis alone is estimated to be present in 4.9% of the adult population. Co-existence of dual pathology may complicate clinical presentation and necessitates a wise and individually based decision process. Objectives To estimate the co-existence of cervical canal stenosis in surgical lumbar canal stenosis patients and its reflection on decision-making regarding surgery. Methods It is a prospective study that was conducted on 70 cases with symptomatic lumbar canal stenosis by investigating them for cervical canal stenosis clinically and radiologically. Results The co-existence of cervical and lumbar canal stenoses was seen in 62 cases (88.57%); cases with relative cervical stenosis were 25 (35.714%) and absolute cervical stenosis was 37 (52.857%). Cases with no cervical stenosis were 8 (11.428%) and cases with relative lumbar stenosis were 22 (31.428%), while cases with absolute lumbar stenosis were 48 (68.571%). Cases with symptomatic cervical canal stenosis were 30 (42.857%). Cases with asymptomtic cervical canal stenosis were 32 (45.71%). Conclusion Tandem spinal stenosis (TSS) is not uncommon and MRI cervical spine should be done for every lumbar canal stenosis patient especially if indicated by history or clinical examination.

P41. Two Year Clinical Results of X-Stop Interspinous Decompression Device in the Management of Symptomatic Lumbar Canal Stenosis

2008 ◽  
Vol 8 (5) ◽  
pp. 121S-122S
Author(s):  
Anjali Nandakumar ◽  
Natasha Annette Clark ◽  
Naval Bilolikar ◽  
Agata Pawulska ◽  
Alexandru Mertic ◽  
...  
Keyword(s):  
Clinical Results ◽  
Lumbar Canal Stenosis ◽  
Canal Stenosis
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