scholarly journals Evaluating the longitudinal effect of colorectal surgery on health‐related quality of life in patients with colorectal cancer

2021 ◽  
Author(s):  
Muriël Reudink ◽  
Charlotte J. L. Molenaar ◽  
Cynthia S. Bonhof ◽  
Loes Janssen ◽  
Floortje Mols ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Colorectal Surgery ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Exploring the relationship among dispositional optimism, health-related quality of life, and CIPN severity among colorectal cancer patients with chronic peripheral neuropathy

2021 ◽  
Author(s):  
Hester.R. Trompetter ◽  
Cynthia S. Bonhof ◽  
Lonneke V. van de Poll-Franse ◽  
Gerard Vreugdenhil ◽  
Floortje Mols
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Peripheral Neuropathy ◽  
Cancer Patients ◽  
Anxiety Symptoms ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Abstract Purpose Chemotherapy-induced peripheral neuropathy ((CI)PN) becomes chronic in 30% of cancer patients. Knowledge of predictors of chronic (CI)PN and related impairments in health-related quality of life (HRQoL) is lacking. We examined the role of optimism in chronic (CI)PN severity and associated HRQoL in colorectal cancer (CRC) patients up to two years after diagnosis. Methods CRC patients from a prospective cohort study participated, with sensory peripheral neuropathy (SPN) 1 year after diagnosis (n = 142). Multivariable regression analyses examined the cross-sectional association between optimism (measured by the LOT-R) and SPN severity/HRQoL (measured by the EORTC QLQ-CIPN20 and QLQ-C30), as well as the prospective association in a subsample that completed measures 2 years after diagnosis and still experienced SPN (n = 86). Results At 1-year follow-up, higher optimism was associated with better global HRQoL, and better physical, role, emotional, cognitive, and social functioning (all p < .01). Optimism at year one was also prospectively associated with better global HRQoL (p < .05), and emotional and cognitive functioning at 2-year follow-up (both p < .01). Optimism was not related to self-reported SPN severity. Significant associations were retained when controlling for demographic/clinical variables, and became non-significant after controlling for depressive and anxiety symptoms. Conclusions Optimism and depressive and anxiety symptoms are associated with HRQoL in CRC patients with chronic (CI)PN. Future research may illuminate the mechanisms that these factors share, like the use of (non)adaptive coping styles such as avoidance and acceptance that may inform the design of targeted interventions to help patients to adapt to chronic (CI)PN.

scholarly journals The course of peripheral neuropathy and its association with health-related quality of life among colorectal cancer patients

2020 ◽  
Author(s):  
Cynthia S. Bonhof ◽  
Lonneke V. van de Poll-Franse ◽  
Dareczka K. Wasowicz ◽  
Laurens V. Beerepoot ◽  
Gerard Vreugdenhil ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Peripheral Neuropathy ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Eortc Qlq ◽  
The Impact

Abstract Purpose To gain more insight into the course of chemotherapy-induced peripheral neuropathy (CIPN) and its impact on health-related quality of life (HRQoL) in a population-based sample of colorectal cancer (CRC) patients up to 2 years after diagnosis. Methods All newly diagnosed CRC patients from four hospitals in the Netherlands were eligible for participation in an ongoing prospective cohort study. Patients (n = 340) completed questions on CIPN (EORTC QLQ-CIPN20) and HRQoL (EORTC QLQ-C30) before initial treatment (baseline) and 1 and 2 years after diagnosis. Results Among chemotherapy-treated patients (n = 105), a high sensory peripheral neuropathy (SPN) level was reported by 57% of patients at 1 year, and 47% at 2-year follow-up, whereas a high motor peripheral neuropathy (MPN) level was reported by 47% and 28%, at years 1 and 2, respectively. Linear mixed model analyses showed that SPN and MPN symptoms significantly increased from baseline to 1-year follow-up and did not return to baseline level after 2 years. Patients with a high SPN or MPN level reported a worse global quality of life and a worse physical, role, emotional, cognitive, and social functioning compared with those with a low SPN or MPN level. Conclusions Future studies should focus on understanding the mechanisms underlying CIPN so targeted interventions can be developed to reduce the impact of CIPN on patient’s lives. Implications for cancer survivors Patients need to be informed of both CIPN and the impact on HRQoL.

scholarly journals Associations of sedentary time and patterns of sedentary time accumulation with health-related quality of life in colorectal cancer survivors

2016 ◽  
Vol 4 ◽  
pp. 262-269 ◽  
Author(s):  
Eline H. van Roekel ◽  
Elisabeth A.H. Winkler ◽  
Martijn J.L. Bours ◽  
Brigid M. Lynch ◽  
Paul J.B. Willems ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Cancer Survivors ◽  
Sedentary Time ◽  
Health Related Quality ◽  
Colorectal Cancer Survivors ◽  
Related Quality ◽  
Health Related ◽  
Time Accumulation

scholarly journals Health-related quality of life and oncologic outcomes after surgery in older adults with colorectal cancer

2019 ◽  
Vol 28 (6) ◽  
pp. 2857-2865
Author(s):  
Andrew M. Blakely ◽  
Dayana Chanson ◽  
F. Lennie Wong ◽  
Oliver S. Eng ◽  
Stephen M. Sentovich ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Older Adults ◽  
Oncologic Outcomes ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Health related quality of life in older or frail patients with advanced colorectal cancer treated with dose reduced capecitabine

2018 ◽  
Vol 9 (6) ◽  
pp. 659-664 ◽  
Author(s):  
Daniel Breadner ◽  
Mark David Vincent ◽  
Derek Jonker ◽  
Christine Cripps ◽  
Paul Klimo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Advanced Colorectal Cancer ◽  
Health Related Quality ◽  
Frail Patients ◽  
Related Quality ◽  
Health Related

scholarly journals Health-related quality of life in colorectal cancer survivors: are there differences between sporadic and hereditary patients?

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Allison M. Burton-Chase ◽  
Wendy M. Parker ◽  
Kirsten M. Donato ◽  
Shannon McCormick ◽  
Ellen R. Gritz ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Cancer Survivors ◽  
Health Related Quality ◽  
Colorectal Cancer Survivors ◽  
Related Quality ◽  
Health Related
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