Perioperative blood transfusions and survival in resected pancreatic adenocarcinoma patients given multimodality therapy

2021 ◽  
Author(s):  
Timothy E. Newhook ◽  
Laura R. Prakash ◽  
Jose Soliz ◽  
Shannon Hancher‐Hodges ◽  
B. Bryce Speer ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Multimodality Therapy ◽  
Blood Transfusions

scholarly journals Regional disparities in pancreatic adenocarcinoma treatment: Is multimodality therapy the answer?

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e71-e72 ◽  
Author(s):  
G.G. Kasumova ◽  
M.F. Eskander ◽  
S.L. de Geus ◽  
M. Matiotti ◽  
S.C. Ng ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Regional Disparities ◽  
Multimodality Therapy

Regional variation in the treatment of pancreatic adenocarcinoma: Decreasing disparities with multimodality therapy

Surgery ◽  
2017 ◽  
Vol 162 (2) ◽  
pp. 275-284 ◽  
Author(s):  
Gyulnara G. Kasumova ◽  
Mariam F. Eskander ◽  
Susanna W.L. de Geus ◽  
Mario Matiotti Neto ◽  
Omidreza Tabatabaie ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Regional Variation ◽  
Multimodality Therapy

scholarly journals Impact of perioperative blood transfusions on survival in patients with borderline resectable pancreatic adenocarcinoma after neoadjuvant therapy

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S43-S44
Author(s):  
R.A. Snyder ◽  
L.R. Prakash ◽  
N. Narula ◽  
B.J. Kim ◽  
M.P. Kim ◽  
...  
Keyword(s):  
Neoadjuvant Therapy ◽  
Pancreatic Adenocarcinoma ◽  
Blood Transfusions ◽  
Borderline Resectable

scholarly journals Multimodality Therapy Offers a Chance for Cure in Patients with Pancreatic Adenocarcinoma Deemed Unresectable at First Operative Exploration

2012 ◽  
Vol 215 (1) ◽  
pp. 41-51 ◽  
Author(s):  
Mark J. Truty ◽  
Ryan M. Thomas ◽  
Matthew H. Katz ◽  
Jean-Nicolas Vauthey ◽  
Christopher Crane ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Multimodality Therapy ◽  
Operative Exploration

National Trends in Centralization of Surgical Care and Multimodality Therapy for Pancreatic Adenocarcinoma

2019 ◽  
Vol 24 (9) ◽  
pp. 2021-2029
Author(s):  
Alexander V. Fisher ◽  
Yue Ma ◽  
Xing Wang ◽  
Stephanie A. Campbell-Flohr ◽  
Paul J. Rathouz ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Surgical Care ◽  
Multimodality Therapy ◽  
National Trends

Factors Associated with Improved Survival after Resection of Pancreatic Adenocarcinoma

2015 ◽  
Vol 122 (2) ◽  
pp. 317-324 ◽  
Author(s):  
Tyler R. Call ◽  
Nathan L. Pace ◽  
Datus B. Thorup ◽  
Derric Maxfield ◽  
Ben Chortkoff ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Pancreatic Adenocarcinoma ◽  
Survival Data ◽  
Patient Survival ◽  
Anesthetic Management ◽  
Hazard Ratio ◽  
Histologic Grade ◽  
Blood Transfusions ◽  
Advanced Tumor Stage ◽  
Advanced Tumor

Abstract Background: Several retrospective studies suggest that perioperative care and anesthetic management for cancer resection may influence cancer recurrence or patient survival. Various intraoperative techniques such as paravertebral blocks, decreased opioid use, immunomodulation, and perioperative antiinflammatory administration, have previously been assessed for improved patient survival. The aim of this study was to assess associations between perioperative management and survival in patients undergoing resection of pancreatic adenocarcinoma. Methods: Survival data and anesthetic records for 144 patients who had surgical resection of pancreatic adenocarcinoma from 2001 to 2012 were obtained and associations were sought between survival and 19 predefined variables. The authors performed a propensity weighted multivariable statistical analysis using Cox proportional hazards. Results: Median length of survival was 562 days with 95% confidence interval (471, 680). In a multivariable Cox proportional hazard model of survival, the authors found increased survival in patients who received perioperative epidural analgesia and/or intraoperative dexamethasone. There was a 44% hazard ratio reduction, hazard ratio = 0.56, 95% confidence interval (0.38, 0.87), with dexamethasone. Adjuvant postoperative chemotherapy was associated with longer survival. A decrease in survival was noted in patients who received intraoperative blood transfusions, had poorer histologic grade, and advanced tumor stage. Conclusions: The authors report an association between perioperative dexamethasone administration and improved survival in human pancreatic adenocarcinoma patients. An association between use of epidural anesthesia during primary pancreatic cancer surgery and prolonged survival was also observed. Previously identified associations between perioperative blood transfusions and poor tumor histologic grade and decreased survival were confirmed. Further investigations regarding the use of perioperative dexamethasone and neuraxial anesthesia in this patient population are warranted.

scholarly journals Trajectory of care and use of multimodality therapy in older patients with pancreatic adenocarcinoma

Surgery ◽  
2014 ◽  
Vol 156 (2) ◽  
pp. 280-289 ◽  
Author(s):  
Abhishek D. Parmar ◽  
Gabriela M. Vargas ◽  
Nina P. Tamirisa ◽  
Kristin M. Sheffield ◽  
Taylor S. Riall
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Older Patients ◽  
Multimodality Therapy ◽  
Trajectory Of Care

scholarly journals Perioperative blood transfusions for vein resection during pancreaticoduodenectomy for pancreatic adenocarcinoma: Identification of clinical targets for optimization

HPB ◽  
2019 ◽  
Vol 21 (7) ◽  
pp. 841-848
Author(s):  
Rebecca A. Snyder ◽  
Laura R. Prakash ◽  
Graciela M. Nogueras-Gonzalez ◽  
Michael P. Kim ◽  
Thomas A. Aloia ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Blood Transfusions ◽  
Vein Resection

Trajectory of Care and Use of Multimodality Therapy in Patients with Locoregional Pancreatic Adenocarcinoma

2014 ◽  
Vol 186 (2) ◽  
pp. 643
Author(s):  
A.D. Parmar ◽  
G.M. Vargas ◽  
N.P. Tamirisa ◽  
K.M. Sheffield ◽  
T.S. Riall
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Multimodality Therapy ◽  
Trajectory Of Care

Multimodality therapy of localized unresectable pancreatic adenocarcinoma

Cancer ◽  
1984 ◽  
Vol 54 (9) ◽  
pp. 1991-1998 ◽  
Author(s):  
Richard Whittington ◽  
Lawrence Solin ◽  
Mohammed Mohiuddin ◽  
Ronald I. Cantor ◽  
Francis E. Rosato ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Multimodality Therapy
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