Comparison of comprehensive complication index and Clavien–Dindo classification in patients with retroperitoneal sarcoma

Measuring the impact of complications after surgery for retroperitoneal sarcoma: Is comprehensive complication index better than Clavien-Dindo Classification?

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2021.12.010 ◽

2021 ◽

Author(s):

Laura Ruspi ◽

Ferdinando Carlo Maria Cananzi ◽

Fulvia Aymerito ◽

Federico Sicoli ◽

Laura Samà ◽

...

Keyword(s):

Retroperitoneal Sarcoma ◽

Comprehensive Complication Index ◽

The Impact ◽

Better Than

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Featured Clinical Trial: Preoperative Radiotherapy for Retroperitoneal Sarcoma

PsycEXTRA Dataset ◽

10.1037/e481372006-006 ◽

2005 ◽

Author(s):

Keyword(s):

Clinical Trial ◽

Preoperative Radiotherapy ◽

Retroperitoneal Sarcoma

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The Impact of Time Interval between Hepatic Resection and Liver Transplantation on Clinical Outcome in Patients with Hepatocellular Carcinoma

Cancers ◽

10.3390/cancers13102398 ◽

2021 ◽

Vol 13 (10) ◽

pp. 2398

Author(s):

Matteo Serenari ◽

Enrico Prosperi ◽

Marc-Antoine Allard ◽

Michele Paterno ◽

Nicolas Golse ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Transplantation ◽

Hepatic Resection ◽

Primary Outcome ◽

Polynomial Regression ◽

Secondary Outcome ◽

Time Interval ◽

Comprehensive Complication Index ◽

Fractional Polynomial ◽

The Impact

Hepatic resection (HR) for hepatocellular carcinoma (HCC) may require secondary liver transplantation (SLT). However, a previous HR is supposed to worsen post-SLT outcomes. Data of patients treated by SLT between 2000 and 2018 at two tertiary referral centers were analyzed. The primary outcome of the study was to analyze the impact of HR on post-LT complications. A Comprehensive Complication Index ≥ 29.6 was chosen as cutoff. The secondary outcome was HCC-related death by means of competing-risk regression analysis. In the study period, 140 patients were included. Patients were transplanted in a median of 23 months after HR (IQR 14–41). Among all the features analyzed regarding the prior HR, only time interval between HR and SLT (time HR-SLT) was an independent predictor of severe complications after LT (OR = 0.98, p < 0.001). According to fractional polynomial regression, the probability of severe complications increased up to 15 months after HR (43%), then slowly decreased over time (OR = 0.88, p < 0.001). There was no significant association between HCC-related death and time HR-SLT at the multivariable competing risks regression model (SHR, 1.06; 95% CI: 0.69–1.62, p = 0.796). This study showed that time HR-SLT was key in predicting complications after LT, without affecting HCC-related death.

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PO-1233: Perioperative Radiotherapy with a Moderate Dose-Escalation for Retroperitoneal Sarcoma (RPS).

Radiotherapy and Oncology ◽

10.1016/s0167-8140(21)01251-2 ◽

2020 ◽

Vol 152 ◽

pp. S649

Author(s):

M. Nuñez Baez ◽

A. Montero ◽

X. Chen-Zhao ◽

A. Acosta ◽

B. Alvarez ◽

...

Keyword(s):

Dose Escalation ◽

Retroperitoneal Sarcoma ◽

Moderate Dose

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Doege-Potter syndrome presenting as ‘end-stage renal disease-associated hypoglycaemia’: a primary presentation of retroperitoneal sarcoma

BMJ Case Reports ◽

10.1136/bcr-2020-235549 ◽

2020 ◽

Vol 13 (8) ◽

pp. e235549

Author(s):

Skand Shekhar ◽

Julie Chen ◽

Kaniksha Desai

Keyword(s):

Renal Disease ◽

End Stage Renal Disease ◽

Haemorrhagic Shock ◽

Retroperitoneal Sarcoma ◽

Obstructive Nephropathy ◽

Aged Woman ◽

Surgical Debulking ◽

Middle Aged Woman ◽

Stage Renal Disease ◽

End Stage

A middle-aged woman with end-stage renal disease (ESRD) due to obstructive nephropathy presented to the hospital for an episode of unresponsiveness and hypoglycaemia. Initially, she was diagnosed with hypoglycaemia associated with ESRD and was discharged. However, she returned to the hospital after experiencing tonic–clonic seizures and recurrent hypoglycaemia. Her hypoglycaemia workup revealed an elevated insulin-like growth factor 2 (IGF2) to IGF1 ratio consistent with paraneoplastic IGF2 secretion. Subsequently, a CT abdomen revealed a retroperitoneal mass, found to be a retroperitoneal sarcoma. Her hypoglycaemia was treated with glucocorticoids and growth hormone. Surgical debulking of her tumour was attempted, but she expired due to postoperative haemorrhagic shock. Doege-Potter syndrome is a rare cause of hypoglycaemia which should be suspected in any new-onset, worsening, inexplicable or refractory hypoglycaemia, particularly in non-diabetic ESRD. Here we present a report of retroperitoneal sarcoma presenting with hypoglycaemia in a patient with ESRD without diabetes.

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