scholarly journals Concurrent lymphovascular and perineural invasion after preoperative therapy for gastric adenocarcinoma is associated with decreased survival

2021 ◽  
Author(s):  
Alisa N. Blumenthaler ◽  
Timothy E. Newhook ◽  
Naruhiko Ikoma ◽  
Jeannelyn S. Estrella ◽  
Mariela Blum Murphy ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Perineural Invasion ◽  
Preoperative Therapy

scholarly journals The presence of metastases in regional lymph nodes is associated with tumor size and depth of invasion in sporadic gastric adenocarcinoma

2014 ◽  
Vol 27 (1) ◽  
pp. 18-21 ◽  
Author(s):  
Eduardo CAMBRUZZI ◽  
Andreza Mariane de AZEREDO ◽  
Ardala KRONHART ◽  
Katia Martins FOLTZ ◽  
Cláudio Galeano ZETTLER ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Gastric Adenocarcinoma ◽  
Tumor Size ◽  
Perineural Invasion ◽  
Histological Grade ◽  
Lymph Node Status ◽  
Depth Of Invasion ◽  
Tumor Spread ◽  
Signet Ring

Background: Gastric adenocarcinoma is more often found in men over 50 years in the form of an antral lesion. The tumor has heterogeneous histopathologic features and a poor prognosis (median survival of 15% in five years). Aim: To estimate the relationship between the presence of nodal metastasis and other prognostic factors in sporadic gastric adenocarcinoma. Method: Were evaluated 164 consecutive cases of gastric adenocarcinoma previously undergone gastrectomy (partial or total), without clinical evidence of distant metastasis, and determined the following variables: topography of the lesion, tumor size, Borrmann macroscopic configuration, histological grade, early or advanced lesions, Lauren histological subtype, presence of signet ring cell, degree of invasion, perigastric lymph node status, angiolymphatic/perineural invasion, and staging. Results: Were found 21 early lesions (12.8%) and 143 advanced lesions (87.2%), with a predominance of lesions classified as T3 (n=99/60, 4%) and N1 (n=62/37, 8%). The nodal status was associated with depth of invasion (p<0.001) and tumor size (p<0.001). The staging was related to age (p=0.048), histological grade (p=0.003), and presence of signet ring cells (p = 0.007), angiolymphatic invasion (p = 0.001), and perineural invasion (p=0.003). Conclusion: In gastric cancer, lymph node involvement, tumor size and depth of invasion are histopathological data associated with the pattern of growth/tumor spread, suggesting that a wide dissection of perigastric lymph nodes is a fundamental step in the surgical treatment of these patients.

Preoperative Therapy for Gastric Adenocarcinoma is Protective for Poor Oncologic Outcomes in Patients with Complications After Gastrectomy

2018 ◽  
Vol 25 (9) ◽  
pp. 2720-2730 ◽  
Author(s):  
Diego Vicente ◽  
Naruhiko Ikoma ◽  
Yi-Ju Chiang ◽  
Keith Fournier ◽  
Ching-Wei D. Tzeng ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Preoperative Therapy ◽  
Oncologic Outcomes

Patterns of Initial Recurrence in Gastric Adenocarcinoma in the Era of Preoperative Therapy

2017 ◽  
Vol 24 (9) ◽  
pp. 2679-2687 ◽  
Author(s):  
Naruhiko Ikoma ◽  
Hsiang-Chun Chen ◽  
Xuemei Wang ◽  
Mariela Blum ◽  
Jeannelyn S. Estrella ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Preoperative Therapy ◽  
Initial Recurrence

scholarly journals Insufficient lymph node assessment in gastric adenocarcinoma

2019 ◽  
Vol 31 (1) ◽  
Author(s):  
Nezhat Khanjani ◽  
Sepideh Mirzaei ◽  
Hamid Nasrolahi ◽  
Seyed Hasan Hamedi ◽  
Ahmad Mosalaei ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Gastric Adenocarcinoma ◽  
Perineural Invasion ◽  
Univariate Analysis ◽  
Neoadjuvant Treatment ◽  
Primary Tumor Size ◽  
Lymph Node Assessment ◽  
Lymph Node Examination ◽  
Type Of Surgery

Abstract Background This study aimed to investigate the sufficient (≥ 16) lymph node assessment in 449 patients with gastric adenocarcinoma and literature review. Methods Four hundred and forty-nine patients with pathologically confirmed locoregional invasive gastric adenocarcinoma from 2004 to 2013 were included. A standard surgical resection was performed for all the patients with (n = 16) or without (n = 433) neoadjuvant treatment. Results In this study, 301 men and 148 women with a median age of 58 (range 21–88) years were included. The median total numbers of examined lymph nodes were 9 (range 0–55). Ninety-five patients (21.2%) had adequate (≥ 16) lymph node examination, and 70 patients (15.6%) had no examined lymph nodes. In univariate analysis, total or near total gastrectomy (P <  0.001), advanced node stage (P < 0.001), primary tumor size > 6 cm (P < 0.001), and the presence of perineural invasion (P = 0.039) were associated with more average number of examined lymph nodes. On multivariate analysis, node stage (P < 0.001) and type of surgery (P = 0.008) were independent predictive factors. Conclusion In this study, approximately one in five patients with gastric adenocarcinoma had sufficient lymph node assessment. More studies are suggested for identifying a true inadequate lymph node dissection from insufficient lymph node assessment.

scholarly journals Prognostic Significance of Lymphatic, Venous and Perineural Invasion After Neoadjuvant Chemotherapy in Patients with Gastric Adenocarcinoma

2020 ◽  
Vol 27 (9) ◽  
pp. 3296-3304 ◽  
Author(s):  
Benjamin L. Woodham ◽  
Jakub Chmelo ◽  
Claire L. Donohoe ◽  
Anantha Madhavan ◽  
Alexander W. Phillips
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Gastric Adenocarcinoma ◽  
Perineural Invasion ◽  
Prognostic Significance

scholarly journals Tubular gastric adenocarcinoma: machine learning-based CT texture analysis for predicting lymphovascular and perineural invasion

2020 ◽  
Vol 26 (6) ◽  
pp. 515-522
Author(s):  
Aytul Hande Yardimci ◽  
◽  
Burak Kocak ◽  
Ceyda Turan Bektas ◽  
Ipek Sel ◽  
...  
Keyword(s):  
Machine Learning ◽  
Texture Analysis ◽  
Gastric Adenocarcinoma ◽  
Perineural Invasion ◽  
Ct Texture Analysis

415: Downregula Tion of the Signaling Adapter Pinch in Prostate Cancer Perineural Invasion

2005 ◽  
Vol 173 (4S) ◽  
pp. 113-113
Author(s):  
W. Marie Campana ◽  
Jessica Wang-Rodriguez ◽  
Daniel A. Nachtsheim ◽  
Ann Rearden
Keyword(s):  
Prostate Cancer ◽  
Perineural Invasion
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