Predictive value of tumor‐infiltrating lymphocytes for response to neoadjuvant chemotherapy and breast cancer prognosis

2020 ◽  
Vol 123 (1) ◽  
pp. 89-95
Author(s):  
Xiaomin Li ◽  
Qiuwen Tan ◽  
Hongjiang Li ◽  
Xiaoqin Yang
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Predictive Value ◽  
Tumor Infiltrating Lymphocytes ◽  
Breast Cancer Prognosis ◽  
Cancer Prognosis ◽  
Infiltrating Lymphocytes ◽  
Response To Neoadjuvant Chemotherapy

The value of tumor-infiltrating lymphocytes and CD8 expression as a predictor of response to anthracycline-based neoadjuvant chemotherapy in invasive breast carcinoma of no special type

2021 ◽  
pp. 1-6
Author(s):  
Upik A. Miskad ◽  
Rizki A. Rifai ◽  
Rina Masadah ◽  
Berti Nelwan ◽  
Djumadi Ahmad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Immune System ◽  
Breast Carcinoma ◽  
Neoadjuvant Chemotherapy ◽  
Predictive Value ◽  
Disease Free Survival ◽  
Tumor Infiltrating Lymphocytes ◽  
Invasive Breast Carcinoma ◽  
Study Results ◽  
Infiltrating Lymphocytes

BACKGROUND: The immune system is known to play an important role in tumor cell eradication. Although cancer cells were able to escape from the immune system, many studies showed mononuclear inflammatory cell infiltrates known as tumor-infiltrating lymphocytes (TILs) on breast cancer histopathology specimens showed better prognosis, including in disease-free survival (DFS) and chemotherapy responses. OBJECTIVE: This study aimed to reveal the predictive value of tumor-infiltrating lymphocytes (TILs) levels and CD8 expression in invasive breast carcinoma of no special type patients’ samples on response to anthracycline-based neoadjuvant chemotherapy. METHODS: 75 pre-treatment biopsy samples that were diagnosed as invasive breast carcinoma of no special type were evaluated. TILs level determined following recommendations of International TILs Working Group 2014, CD8 expression assessed semiquantitatively after immunohistochemistry staining. Response to anthracycline-based neoadjuvant chemotherapy evaluated clinically using Response Evaluation Criteria in Solid Tumours (RECIST) criteria and pathologically by evaluating hematoxylin and eosin (H&E)-stained slides from mastectomy specimens after 3 or 4 cycles of neoadjuvant chemotherapy. RESULTS: Chi-squared analysis showed a significant relationship between TILs level and CD8 expression with chemotherapy responses clinically (p = 0.011 and p = 0.017 respectively) but not pathologically. Furthermore, the logistic regression test exhibit the predictive value of TILs level was 66.7% and CD8 expression was 64%. CONCLUSIONS: This study results suggest that TILs level and CD8 expression may be added as predictive factors to the response of anthracycline-based neoadjuvant chemotherapy, and oncologists may take benefit in breast cancer patient’s management.

scholarly journals FOXP3 expression in tumor cells and tumor-infiltrating lymphocytes is associated with breast cancer prognosis

2013 ◽  
Vol 1 (4) ◽  
pp. 625-632 ◽  
Author(s):  
MIKI TAKENAKA ◽  
NAOKO SEKI ◽  
UHI TOH ◽  
SATOSHI HATTORI ◽  
AKIHIKO KAWAHARA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Tumor Infiltrating Lymphocytes ◽  
Foxp3 Expression ◽  
Breast Cancer Prognosis ◽  
Cancer Prognosis ◽  
Infiltrating Lymphocytes
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