Prognostic value of different metastatic sites for patients with FIGO stage IVB endometrial cancer after surgery: A SEER database analysis

2020 ◽  
Author(s):  
Hui Li ◽  
Rusi Zhang ◽  
Cuiying Chen ◽  
Chuling Wu ◽  
Haoliang Lin ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Prognostic Value ◽  
Figo Stage ◽  
Seer Database ◽  
Database Analysis ◽  
Stage Ivb ◽  
Metastatic Sites

Prognostic value of distant metastatic sites in stage IV endometrial cancer: A SEER database study of 2948 women

2020 ◽  
Vol 149 (1) ◽  
pp. 16-23 ◽  
Author(s):  
Yan Liu ◽  
Shuqi Chi ◽  
Xing Zhou ◽  
Rong Zhao ◽  
Chengyu Xiao ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Prognostic Value ◽  
Stage Iv ◽  
Seer Database ◽  
Database Study ◽  
Metastatic Sites

scholarly journals The FIGO Stage IVA Versus IVB of Ovarian Cancer: Prognostic Value and Predictive Value for Neoadjuvant Chemotherapy

2018 ◽  
Vol 28 (3) ◽  
pp. 453-458 ◽  
Author(s):  
Parvin Tajik ◽  
Roelien van de Vrie ◽  
Mohammad H. Zafarmand ◽  
Corneel Coens ◽  
Marrije R. Buist ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Overall Survival ◽  
Neoadjuvant Chemotherapy ◽  
Epithelial Ovarian Cancer ◽  
Prognostic Value ◽  
Median Overall Survival ◽  
Stage Iv ◽  
Figo Stage ◽  
Figo Staging ◽  
Stage Ivb

ObjectiveThe revised version of the International Federation of Gynaecology and Obstetrics (FIGO) staging system (2014) for epithelial ovarian cancer includes a number of changes. One of these is the division of stage IV into 2 subgroups. Data on the prognostic and predictive significance of this classification are scarce. The effect of neoadjuvant chemotherapy (NACT) versus primary debulking surgery (PDS) in relation to the subclassification of FIGO stage IV is also unknown.MethodsWe used data of the EORTC 55971 trial, in which 670 patients with previous stage IIIC or IV epithelial ovarian cancer were randomly assigned to PDS or NACT; 160 patients had previous stage IV. Information on previous FIGO staging and presence of pleural effusion with positive cytology were used to classify tumors as either stage IVA or IVB. We tested the association between stage IVA/IVB and survival to evaluate the prognostic value and interactions between stage, treatment, and survival to evaluate the predictive performance.ResultsAmong the 160 participants with previous stage IV disease, 103 (64%) were categorized as stage IVA and 57 (36%) as stage IVB tumors. Median overall survival was 24 months in FIGO stage IVA and 31 months in stage IVB patients (P = 0.044). Stage IVB patients treated with NACT had 9 months longer median overall survival compared with IVB patients undergoing PDS (P = 0.025), whereas in IVA patients, no significant difference was observed (24 vs 26 months, P = 0.48).ConclusionsThe reclassification of FIGO stage IV into stage IVA or IVB was not prognostic as expected. Compared with stage IVA patients, stage IVB patients have a better overall survival and may benefit more from NACT.

scholarly journals Prognostic value of clinical staging according to TNM in patients with SCLC: a real-world SEER database analysis

2021 ◽  
pp. 100266
Author(s):  
Edurne Arriola ◽  
José Manuel Trigo Perez ◽  
Amparo Sanchez Gastaldo ◽  
Alejandro Navarro ◽  
Coral Perez ◽  
...  
Keyword(s):  
Real World ◽  
Prognostic Value ◽  
Clinical Staging ◽  
Seer Database ◽  
Database Analysis

scholarly journals Site-specific metastases of gallbladder adenocarcinoma and their prognostic value for survival: a SEER-based study

2021 ◽  
Author(s):  
Yingnan Yang ◽  
Zhuolong Tu ◽  
Chentao Ye ◽  
Huajie Cai ◽  
Shouzhang Yang ◽  
...  
Keyword(s):  
Bone Metastases ◽  
Prognostic Value ◽  
Primary Site ◽  
Survival Outcomes ◽  
Seer Database ◽  
Site Specific ◽  
Isolated Lung ◽  
Gallbladder Adenocarcinoma ◽  
Metastatic Sites ◽  
Isolated Liver

Abstract Background: Gallbladder cancer is a rare but highly malignant cancer, which often progresses to a metastatic stage when diagnosed because of its asymptomatic manifestation. In this study, we intended to analyze the prognostic value of metastatic gallbladder adenocarcinoma (GBA) with site-specific metastases.Methods: Using the Surveillance, Epidemiology, and End Results (SEER) database, GBA patients diagnosed with metastases between 2010 and 2016 were selected to identify the prognosis according to the isolated metastatic sites, including liver, lung, bone, brain and distant lymph nodes (DL). Kaplan-Meier methods were used for survival comparisons and multivariable Cox regression models were constructed to find out independent factors that associated with survival.Results: Data from 1526 eligible patients were extracted from the SEER database. Among the patients, 788 (51.6%) had isolated liver metastases, 80 (5.2%) had isolated distant nodal involvement, 45 (2.9%) had isolated lung metastases, 21 (1.4%) had isolated bone metastases, 2 (0.1%) had isolated brain metastases and 590 (38.7%) had multiple metastases. No significant survival difference was shown between patients with single or multisite metastases (P>0.05). Patients with isolated lung or DL metastases had significant better survival outcomes than those with isolated bone metastases (P<0.05). Multivariate analysis showed that performing surgery at primary site, receiving chemotherapy were associated with better OS and CSS for patients with isolated liver or DL metastases.Conclusions: The study showed that different metastatic sites affect survival outcomes in metastatic GBA patients. Highly selected subset of patients with liver or DL metastases might benefit from surgery at primary site.

scholarly journals MA12.03 Prognostic Value of Clinical Staging According to TNM in SCLC Patients; A Real-World SEER Database Analysis.

2021 ◽  
Vol 16 (3) ◽  
pp. S177
Author(s):  
E. Arriola Aperribay ◽  
J. Trigo Pérez ◽  
A. Sánchez Gastaldo ◽  
A. Navarro Mendivil ◽  
L. Crama ◽  
...  
Keyword(s):  
Real World ◽  
Prognostic Value ◽  
Clinical Staging ◽  
Seer Database ◽  
Database Analysis

Prognostic value of site-specific extra-hepatic disease in hepatocellular carcinoma: a SEER database analysis

2017 ◽  
Vol 11 (7) ◽  
pp. 695-701 ◽  
Author(s):  
Hani Oweira ◽  
Ulf Petrausch ◽  
Daniel Helbling ◽  
Jan Schmidt ◽  
Arianeb Mehrabi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Value ◽  
Hepatic Disease ◽  
Seer Database ◽  
Database Analysis ◽  
Site Specific

The prognostic value of molecular biomarkers in tissue removed by curettage from FIGO stage 1 and 2 endometrioid type endometrial cancer

2009 ◽  
Vol 200 (1) ◽  
pp. 78.e1-78.e8 ◽  
Author(s):  
Anita Steinbakk ◽  
Ivar Skaland ◽  
Einar Gudlaugsson ◽  
Emiel A.M. Janssen ◽  
Kjell H. Kjellevold ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Prognostic Value ◽  
Figo Stage ◽  
Molecular Biomarkers ◽  
Stage 1

scholarly journals Site-specific metastases of gallbladder adenocarcinoma and their prognostic value for survival: a SEER-based study

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yingnan Yang ◽  
Zhuolong Tu ◽  
Chentao Ye ◽  
Huajie Cai ◽  
Shouzhang Yang ◽  
...  
Keyword(s):  
Bone Metastases ◽  
Prognostic Value ◽  
Primary Site ◽  
Survival Outcomes ◽  
Seer Database ◽  
Site Specific ◽  
Isolated Lung ◽  
Gallbladder Adenocarcinoma ◽  
Metastatic Sites ◽  
Isolated Liver

Abstract Background Gallbladder cancer is a rare but highly malignant cancer, which often progresses to a metastatic stage when diagnosed because of its asymptomatic manifestation. In this study, we intended to analyze the prognostic value of metastatic gallbladder adenocarcinoma (GBA) with site-specific metastases. Methods Using the Surveillance, Epidemiology, and End Results (SEER) database, GBA patients diagnosed with metastases between 2010 and 2016 were selected to identify the prognosis according to the isolated metastatic sites, including liver, lung, bone, brain and distant lymph nodes (DL). Kaplan–Meier methods were used for survival comparisons and multivariable Cox regression models were constructed to find out independent factors that associated with survival. Results Data from 1526 eligible patients were extracted from the SEER database. Among the patients, 788 (51.6%) had isolated liver metastases, 80 (5.2%) had isolated distant nodal involvement, 45 (2.9%) had isolated lung metastases, 21 (1.4%) had isolated bone metastases, 2 (0.1%) had isolated brain metastases and 590 (38.7%) had multiple metastases. No significant survival difference was shown between patients with single or multisite metastases (P > 0.05). Patients with isolated lung or DL metastases had significant better survival outcomes than those with isolated bone metastases (P < 0.05). Multivariate analysis showed that performing surgery at primary site, receiving chemotherapy were associated with better OS and CSS for patients with isolated liver or DL metastases. Conclusions The study showed that different metastatic sites affect survival outcomes in metastatic GBA patients. Highly selected subset of patients with liver or DL metastases might benefit from surgery at primary site.

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