Residual tumor volume discriminates prognosis after surgery for neuroendocrine liver metastasis

2019 ◽  
Vol 121 (2) ◽  
pp. 330-336 ◽  
Author(s):  
Yosuke Kasai ◽  
Kenzo Hirose ◽  
Carlos U. Corvera ◽  
Grace E. Kim ◽  
Thomas A. Hope ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Tumor Volume ◽  
Residual Tumor ◽  
Neuroendocrine Liver Metastasis

scholarly journals Dietary Melatonin and Glycine Decrease Tumor Growth through Antiangiogenic Activity in Experimental Colorectal Liver Metastasis

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2035
Author(s):  
Mindaugas Kvietkauskas ◽  
Viktorija Zitkute ◽  
Bettina Leber ◽  
Kestutis Strupas ◽  
Philipp Stiegler ◽  
...  
Keyword(s):  
Side Effects ◽  
Liver Metastasis ◽  
Tumor Volume ◽  
Treatment Strategies ◽  
Blood Parameters ◽  
Proliferation Index ◽  
Micro Computed Tomography ◽  
Cancer Proliferation ◽  
Inhibitory Function ◽  
Over Time

Despite multimodal treatment strategies, clinical outcomes of advanced stage colorectal cancer (CRC) patients remain poor. Neoadjuvant/adjuvant chemotherapy efficacy is limited due to chemoresistance, toxicity, and negative side effects. Since both melatonin and glycine have anti-cancer activities without relevant side effects, this study was designed to investigate their combined effects in experimental CRC liver metastases. CRC metastasis with CC531 cells were induced in male Wistar rats. Melatonin and glycine alone or their combination were supplemented for 14 days (n = 100). Blood parameters, a micro-computed tomography scan (tumor volume over time), and immunohistochemistry for Ki67 and CD31 expression in tumor tissue were compared between groups. Melatonin and glycine alone significantly reduced the tumor volume by 63.2% (p = 0.002) and 43% (p = 0.044) over time, respectively, while tumor volume increased by 8.7% in the controls. Moreover, treatment with melatonin and glycine alone reduced the tumor proliferation index. Most interestingly, the combination therapy did not have any influence on the above-mentioned tumor parameters. The leukocyte count was significantly increased with melatonin at the end of the experiment (p = 0.012) which was due to a high lymphocytes count. Tumor microvascular density was significantly reduced in all treatment groups. The results of this study suggest an inhibitory function for melatonin and glycine alone in the case of CRC liver metastasis growth by acting as natural antiangiogenic molecules, followed by angiogenesis-dependent cancer proliferation and immunomodulation.

scholarly journals Risk Factors for Progression in Vestibular Schwannomas After Incomplete Resection: A Single Center Retrospective Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Jiuhong Li ◽  
Xueyun Deng ◽  
Daibo Ke ◽  
Jian Cheng ◽  
Si Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multivariate Analysis ◽  
Tumor Size ◽  
Tumor Volume ◽  
Univariate Analysis ◽  
Residual Tumor ◽  
Vestibular Schwannomas ◽  
Incomplete Resection ◽  
Cystic Component

Background and Purpose: The risk factors for progression in vestibular schwannomas (VSs) after incomplete resection (IR) remain to be elucidated. The purpose of this study was to investigate the risk factors for progression in remnant VSs after surgery.Methods: From January 2009 to January 2018, 140 consecutive patients who underwent IR of VSs via suboccipital retrosigmoid approach in our institution were retrospectively analyzed. During follow-up, if progression was detected, the patient was classified into Progressive Group (PG); if the residual tumor was stable or shrank, the patient was classified into Stable Group (SG). Univariate analysis and multivariate analysis were used to evaluate the risk factors for progression after IR of VSs.Results: After a mean follow-up of 80.4 months (range, 24–134 months), 35 (25.0%) patients (PG) had a progression, and no progression was detected in 105 (75.0%) patients (SG). The average tumor size was 36.5 ± 8.9 mm in PG and 31.0 ± 9.8 mm in SG, respectively. The residual tumor volume was 304.6 ± 443.3 mm3 in PG and 75.9 ± 60.0 mm3 in SG, respectively. Univariate analysis showed that preoperative tumor size, residual tumor volume, and irregular internal auditory canal (IAC) expansion were significantly different between the two groups, whereas gender, age, cystic component, or Ki-67 labeling index (LI) did not differ significantly between the two groups. Multivariate analysis showed residual tumor volume was the independent risk factor for progression.Conclusions: VSs that underwent IR with larger preoperative size, greater residual tumor volume, or irregular IAC expansion may have a higher progression rate. Strict follow-up with shorter interval in these patients to detect early progression is necessary.

Residual Tumor Volume and Location Predict Progression After Primary Subtotal Resection of Sporadic Vestibular Schwannomas: A Retrospective Volumetric Study

Neurosurgery ◽  
2019 ◽  
Author(s):  
Jonathan D Breshears ◽  
Ramin A Morshed ◽  
Annette M Molinaro ◽  
Michael W McDermott ◽  
Steven W Cheung ◽  
...  
Keyword(s):  
Tumor Volume ◽  
Residual Tumor ◽  
Vestibular Schwannomas ◽  
Subtotal Resection ◽  
Volumetric Study

Repeat hepatectomy for patients with recurrent neuroendocrine liver metastasis: Comparison with first hepatectomy

Surgery ◽  
2020 ◽  
Vol 167 (2) ◽  
pp. 404-409
Author(s):  
Sho Kiritani ◽  
Junichi Arita ◽  
Masaru Matsumura ◽  
Yujiro Nishioka ◽  
Hiroki Kudo ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Repeat Hepatectomy ◽  
Neuroendocrine Liver Metastasis

scholarly journals Factors triggering an additional resection and determining residual tumor volume on intraoperative MRI: analysis from a prospective single-center registry of supratentorial gliomas

2016 ◽  
Vol 40 (3) ◽  
pp. E4 ◽  
Author(s):  
Moritz Scherer ◽  
Christine Jungk ◽  
Alexander Younsi ◽  
Philipp Kickingereder ◽  
Simon Müller ◽  
...  
Keyword(s):  
Prediction Model ◽  
Tumor Volume ◽  
Case Series ◽  
Residual Tumor ◽  
Intraoperative Mri ◽  
Related Factors ◽  
Glioma Surgery ◽  
Who Grade ◽  
Supratentorial Gliomas ◽  
Additional Resection

OBJECTIVE In this analysis, the authors sought to identify variables triggering an additional resection (AR) and determining residual intraoperative tumor volume in 1.5-T intraoperative MRI (iMRI)-guided glioma resections. METHODS A consecutive case series of 224 supratentorial glioma resections (WHO Grades I–IV) from a prospective iMRI registry (inclusion dates January 2011–April 2013) was examined with univariate and multiple regression models including volumetric data, tumor-related, and surgeon-related factors. The surgeon's expectation of an AR, in response to a questionnaire completed prior to iMRI, was evaluated using contingency analysis. A machine-learning prediction model was applied to consider if anticipation of intraoperative findings permits preoperative identification of ideal iMRI cases. RESULTS An AR was performed in 70% of cases after iMRI, but did not translate into an accumulated risk for neurological morbidity after surgery (p = 0.77 for deficits in cases with AR vs no AR). New severe persistent deficits occurred in 6.7% of patients. Initial tumor volume determined frequency of ARs and was independently correlated with larger tumor remnants delineated on iMRI (p < 0.0001). Larger iMRI volume was further associated with eloquent location (p = 0.010) and recurrent tumors (p < 0.0001), and with WHO grade (p = 0.0113). Greater surgical experience had no significant influence on the course of surgery. The surgeon's capability of ruling out an AR prior to iMRI turned out to incorporate guesswork (negative predictive value 43.6%). In a prediction model, AR could only be anticipated with 65% accuracy after integration of confounding variables. CONCLUSIONS Routine use of iMRI in glioma surgery is a safe and reliable method for resection guidance and is characterized by frequent ARs after scanning. Tumor-related factors were identified that influenced the course of surgery and intraoperative decision-making, and iMRI had a common value for surgeons of all experience levels. Commonly, the subjective intraoperative impression of the extent of resection had to be revised after iMRI review, which underscores the manifold potential of iMRI guidance. In combination with the failure to identify ideal iMRI cases preoperatively, this study supports a generous, tumor-oriented rather than surgeon-oriented indication for iMRI in glioma surgery.

scholarly journals Neuroendocrine Liver Metastasis: Prognostic Implications of Primary Tumor Site on Patients Undergoing Curative Intent Liver Surgery

2017 ◽  
Vol 21 (12) ◽  
pp. 2039-2047 ◽  
Author(s):  
Gaya Spolverato ◽  
Fabio Bagante ◽  
Luca Aldrighetti ◽  
George Poultsides ◽  
Todd W. Bauer ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Liver Surgery ◽  
Primary Tumor ◽  
Tumor Site ◽  
Curative Intent ◽  
Primary Tumor Site ◽  
Neuroendocrine Liver Metastasis ◽  
Prognostic Implications

scholarly journals Residual Tumor Volume as Best Outcome Predictor in Low Grade Glioma – A Nine-Years Near-Randomized Survey of Surgery vs. Biopsy

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Roland Roelz ◽  
David Strohmaier ◽  
Ramazan Jabbarli ◽  
Rainer Kraeutle ◽  
Karl Egger ◽  
...  
Keyword(s):  
Tumor Volume ◽  
Residual Tumor ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Outcome Predictor
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