Intraoperative bile spillage is associated with worse survival in gallbladder adenocarcinoma

2019 ◽  
Author(s):  
Andrew M. Blakely ◽  
Paul Wong ◽  
Peiguo Chu ◽  
Susanne G. Warner ◽  
Mustafa Raoof ◽  
...  
Keyword(s):  
Gallbladder Adenocarcinoma ◽  
Bile Spillage

scholarly journals Gallbladder neuroendocrine carcinoma: An important differential diagnosis of gallbladder adenocarcinoma

JGH Open ◽  
2021 ◽  
Author(s):  
Kenji Ikezawa ◽  
Ryoji Takada ◽  
Nobuyasu Fukutake ◽  
Tomoyuki Otsuka ◽  
Shigenori Nagata ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Neuroendocrine Carcinoma ◽  
Important Differential Diagnosis ◽  
Gallbladder Adenocarcinoma

Expression of Cell Cycle-Related Proteins, p16, p53 and p63 as Important Prognostic Markers in Gallbladder Adenocarcinoma

2013 ◽  
Vol 20 (2) ◽  
pp. 409-415 ◽  
Author(s):  
Kyungeun Kim ◽  
Dong-Hoon Kim ◽  
Seoung Wan Chae ◽  
Jun-Ho Shin ◽  
Hong Joo Kim ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Prognostic Markers ◽  
Gallbladder Adenocarcinoma ◽  
Related Proteins

Decision of surgical approach for advanced gallbladder adenocarcinoma based on a Bayesian network

2017 ◽  
Vol 116 (8) ◽  
pp. 1123-1131 ◽  
Author(s):  
Long-Long Cong ◽  
Zhi-Qiang Cai ◽  
Peng Guo ◽  
Chen Chen ◽  
De-Chun Liu ◽  
...  
Keyword(s):  
Bayesian Network ◽  
Surgical Approach ◽  
Gallbladder Adenocarcinoma

scholarly journals Evaluation of P53, E-cadherin, Cox-2, and EGFR protein imunnoexpression on prognostic of resected gallbladder carcinoma

2014 ◽  
Vol 27 (2) ◽  
pp. 126-132 ◽  
Author(s):  
Sergio Renato PAIS-COSTA ◽  
José Francisco de Matos FARAH ◽  
Ricardo ARTIGIANI-NETO ◽  
Sandro José MARTINS ◽  
Alberto GOLDENBERG
Keyword(s):  
Gallbladder Carcinoma ◽  
Radical Resection ◽  
Total Sample ◽  
Palliative Surgery ◽  
Over Expression ◽  
Dismal Prognosis ◽  
Gallbladder Adenocarcinoma ◽  
Independent Variable ◽  
Cox 2 ◽  
E Cadherin

BACKGROUND: Gallbladder carcinoma presents a dismal prognosis. Choice treatment is surgical resection that is associated a high levels of both morbidity and mortality. Best knowledgement of prognostic factors may result a better selection of patients either for surgical or multimodal treatment. AIM: To evaluate tecidual immunoexpression of P53, E-cadherin, Cox-2, and EGFR proteins and to correlate these findings with resected gallbladder adenocarcinoma survival. METHODS: Clinical, laboratorial, surgical, and anatomopathological reports of a series of gallbladder adenocarcinoma patients were collected by individualized questionary. Total sample was 42 patients. Median of age was 72 years (35-87). There were seven men and 35 women. Lesion distribuition in according TNM state was the following: T1 (n=2), T2 (n=5), T3 (n=31), T4 (n=4). Twenty-three patients underwent radical resection (R0), while 19 palliative surgery (R1-R2). A block of tissue microarray with neoplasic tissue of each patient was confected. It was performed evaluation of P53, E-Caderine, COX-2, and EGFR proteins imunoexpression. These findings were correlated with overall survival. RESULTS: Five-year survival was 28%. The median of global survival was eight months. Only immunoexpression of EGFR protein was considered independent variable at multivariated analysis. CONCLUSION: Final prognosis was influenced by over-expression of EGFR protein in tumoral tissue.

Gastrointestinal Stromal Tumor with Synchronous Gallbladder Adenocarcinoma

2013 ◽  
Vol 45 (3) ◽  
pp. 387-391
Author(s):  
Julio A. Diaz-Perez ◽  
Melina Mastrodimos ◽  
Abhinay Reddy
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Gallbladder Adenocarcinoma

Reduced MFAP5 expression in stroma of gallbladder adenocarcinoma and its potential diagnostic utility

2020 ◽  
Author(s):  
Lei Zhao ◽  
Liyan Xu ◽  
Amanda Hemmerich ◽  
N. Lynn Ferguson ◽  
Cynthia D. Guy ◽  
...  
Keyword(s):  
Diagnostic Utility ◽  
Gallbladder Adenocarcinoma

scholarly journals Meningeal carcinomatosis as the initial manifestation of a gallbladder adenocarcinoma associated with a Krukenberg tumor

2003 ◽  
Vol 58 (3) ◽  
pp. 169-172 ◽  
Author(s):  
Tizuko Miyagui ◽  
Luciana Luchemback ◽  
Graça Helena Maia do Canto Teixeira ◽  
Kátia Martins Lopes de Azevedo
Keyword(s):  
Malignant Neoplasm ◽  
Meningeal Carcinomatosis ◽  
Krukenberg Tumor ◽  
Pelvic Tumor ◽  
Cranial Nerve Involvement ◽  
Initial Manifestation ◽  
Cytologic Examination ◽  
Meningeal Irritation ◽  
Gallbladder Adenocarcinoma ◽  
Clinical Pictures

A case of malignant neoplasm is described in which the initial manifestations were mental dysfunction and meningeal irritation, mimicking chronic or subacute meningitis. Physical examination showed cranial nerve involvement and a pelvic tumor. There was progressive deterioration, and death occurred in 2 weeks. The autopsy revealed a gallbladder adenocarcinoma, meningeal carcinomatosis, and ovarian metastasis presenting as a Krukenberg tumor. The authors emphasize the importance of including meningeal carcinomatosis as a possibility in the differential diagnosis of non-characteristic clinical pictures, as well as the importance of the cerebrospinal fluid cytologic examination, repeated as needed, in order to confirm this diagnosis.

scholarly journals Outcome analysis of low pressure versus high pressure pneumoperitoneum laparoscopic cholecystectomy: a randomized clinical study

2017 ◽  
Vol 4 (11) ◽  
pp. 3740
Author(s):  
Salil Mahajan ◽  
Manu Shankar ◽  
Vinod K. Garg ◽  
Vijender Gupta ◽  
Jaya Sorout
Keyword(s):  
High Pressure ◽  
Laparoscopic Cholecystectomy ◽  
Shoulder Pain ◽  
Postoperative Period ◽  
Low Pressure ◽  
Randomized Clinical Study ◽  
Early Return ◽  
Significant Difference ◽  
Duration Of Surgery ◽  
Bile Spillage

Background: Laparoscopic cholecystectomy is established as gold standard for management of cholelithiasis. Intraoperative pneumoperitoneum affects the postoperative outcomes. The current stress is on increasing patient safety. Hence, this prospective study was undertaken to compare the effect of low pressure pneumoperitoneum (LPP <10 mm Hg) versus high pressure pneumoperitoneum (HPP > 14 mm Hg) on postoperative pain and ileus.Methods: 120 patients undergoing laparoscopic cholecystectomy were randomized into the LPP (<10mm Hg) group (n=60) and the HPP (>14 mm Hg) group (n=60). Total duration of surgery, intra-operative gas consumption, occurrence of bile spillage during operation, shoulder pain and abdominal pain in postoperative period, additional requirement of analgesia in postoperative period and postoperative ileus were assessed.Results: There was no significant difference in terms of operative duration, consumption of CO2 gas, intraoperative bile spillage, total hospital stay and tolerance to early feeding. The incidence of shoulder pain was higher in patients who underwent HPP laparoscopic cholecystectomy (p<0.05). There was early recovery and early return of bowel activity in LPP which was statistically significant.Conclusions: Low-pressure pneumoperitoneum is feasible and safe and results in reduced postoperative shoulder tip pain and near-equal operative time with early return of bowel activity compared with high-pressure pneumoperitoneum.

Adverse Outcomes After Bile Spillage in Incidental Gallbladder Cancers

2019 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Michael J. Horkoff ◽  
Zubir Ahmed ◽  
Yuan Xu ◽  
Francis R. Sutherland ◽  
Elijah Dixon ◽  
...  
Keyword(s):  
Adverse Outcomes ◽  
Bile Spillage
Sign in / Sign up

Export Citation Format

Share Document