Secondary angiosarcoma: A fatal complication of chronic lymphedema

2019 ◽  
Author(s):  
Farhad Farzaliyev ◽  
Rainer Hamacher ◽  
Hans‐Ulrich Steinau Professor ◽  
Stefanie Bertram ◽  
Lars Erik Podleska
Keyword(s):  
Fatal Complication ◽  
Chronic Lymphedema ◽  
Secondary Angiosarcoma

scholarly journals Optimal Clinical Management and the Molecular Biology of Angiosarcomas

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3321
Author(s):  
Tom Wei-Wu Chen ◽  
Jessica Burns ◽  
Robin L. Jones ◽  
Paul H. Huang
Keyword(s):  
Clinical Management ◽  
Standard Treatment ◽  
Checkpoint Inhibitors ◽  
Soft Tissue Sarcomas ◽  
Phase 3 ◽  
Molecular Alterations ◽  
Molecular Features ◽  
Different Origins ◽  
Chronic Lymphedema ◽  
Secondary Angiosarcoma

Angiosarcomas comprise less than 3% of all soft tissue sarcomas but have a poor prognosis. Most angiosarcomas occur without obvious risk factors but secondary angiosarcoma could arise after radiotherapy or chronic lymphedema. Surgery remains the standard treatment for localized angiosarcoma but neoadjuvant systemic treatment may improve the curability. For advanced angiosarcoma, anthracyclines and taxanes are the main chemotherapy options. Anti-angiogenic agents have a substantial role but the failure of a randomized phase 3 trial of pazopanib with or without an anti-endoglin antibody brings a challenge to future trials in angiosarcomas. Immune checkpoint inhibitors as single agents or in combination with oncolytic virus may play an important role but the optimal duration remains to be investigated. We also report the current understanding of the molecular pathways involved in angiosarcoma pathogenesis including MYC amplification, activation of angiogenic pathways and different molecular alterations that are associated with angiosarcomas of different aetiology. The success of the patient-partnered Angiosarcoma Project (ASCProject) has provided not only detailed insights into the molecular features of angiosarcomas of different origins but also offers a template for future fruitful collaborations between patients, physicians, and researchers. Lastly, we provide our perspective of future developments in optimizing the clinical management of angiosarcomas.

scholarly journals Stent Embolization Mimicking Acute Myocardial Infarction

2021 ◽  
Vol 9 ◽  
pp. 232470962110365
Author(s):  
Syed Arqum Huda ◽  
Sara Akram Kahlown ◽  
Anojan Pathmanathan ◽  
Muhammad Saad Farooqi ◽  
Mark Charlamb
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Stent Migration ◽  
Safe Procedure ◽  
Significant Morbidity ◽  
Fatal Complication ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Venous Stents

Venous thromboembolism is associated with significant morbidity and mortality if left untreated. Anticoagulation is the cornerstone of treatment. Venous stents are a relatively newer entity that are increasingly being used to treat venous stenosis/occlusion. It is a safe procedure, but complications include vein rupture, arterial puncture, retroperitoneal bleeding, and in-stent thrombosis. Stent migration is a rare but potentially fatal complication. We present a case of venous stent embolization to the heart that presented as a non-ST segment elevation myocardial infarction.

scholarly journals Acetazolamide and SGLT2 inhibitor as potent drugs for a patient with diabetes mellitus and worsening chronic lymphedema: A case report

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Hajime Kataoka
Keyword(s):  
Body Weight ◽  
Fluid Collection ◽  
Sglt2 Inhibitor ◽  
Chloride Concentration ◽  
Tissue Fluid ◽  
Fat Deposits ◽  
Serum Chloride ◽  
The Right ◽  
Chronic Lymphedema

Treatment of lymphedema using a pharmacologic approach is reported to have limited efficacy. Here, I report a patient with type 2 diabetes (T2DM) and acute worsening of her chronic lymphedema, in whom treatment with acetazolamide and a sodiumglucose cotransporter-2 inhibitor (SGLT2i) effectively improved the lymphedema. A 94-year-old woman, who was treated for T2DM, hyperlipidemia, and hypertension for 17 years at my hospital presented to the emergency room because of acute worsening of her chronic right leg lymphedema with increased swelling, tightness, and dull aching. A pharmacologic approach was used to treat her worsening lymphedema. Acetazolamide 500 mg/d was administered to treat the acute tissue fluid collection in the right lymphedematous leg. Ten days later, the patient’s body weight was markedly reduced by 3.2 kg, pitting in the right leg was markedly improved, and the circumference of right limb was decreased. On day 11, the glucose-lowering agent vildagliptin was switched to the SGLT2i empagliflozin 10 mg/d. On day 70, her body weight had decreased further by 2.8 kg, and the circumference of her right limb was greatly reduced compared with that under treatment with acetazolamide. Her serum chloride concentration was increased after treatment, but her hemoglobin and hematocrit values did not change during the study period. In conclusion, acetazolamide and an SGLT2i have acute diuretic effects for draining the excess tissue fluid in the lymphedematous limb without vascular contraction by enhancing vascular tonicity. Additionally, an SGLT2i may have chronic effects for reducing fat deposits in the lymphedematous limb.

A potentially fatal complication of postoperative vomiting

2008 ◽  
Vol 25 (3) ◽  
pp. 257-259 ◽  
Author(s):  
S. Reddy ◽  
M. W. Butt ◽  
G. S. Samra
Keyword(s):  
Postoperative Vomiting ◽  
Fatal Complication

Magnetic resonance imaging appearances in primary and secondary angiosarcoma of the breast

2013 ◽  
Vol 58 (2) ◽  
pp. 208-212 ◽  
Author(s):  
Ailbhe C O'Neill ◽  
Clare D'Arcy ◽  
Enda McDermott ◽  
Ann O'Doherty ◽  
Cecily Quinn ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Angiosarcoma Of The Breast ◽  
Secondary Angiosarcoma

Heating and Compression Bandage Treatment Is Effective for Chronic Lymphedema with Dermatolymphangioadenitis—A Case-Controlled Study

2016 ◽  
Vol 14 (4) ◽  
pp. 233-239 ◽  
Author(s):  
Ke Li ◽  
Ningfei Liu ◽  
Ziyou Yu ◽  
Parviz Sadigh ◽  
Davide Lazzeri ◽  
...  
Keyword(s):  
Controlled Study ◽  
Compression Bandage ◽  
Chronic Lymphedema

Effect of Manual Lymphdrainage Massage on Blood Components and Urinary Neurogormones in Chronic Lymphedema

Angiology ◽  
1981 ◽  
Vol 32 (2) ◽  
pp. 119-127 ◽  
Author(s):  
W. Kurz ◽  
R. Kurz ◽  
Y.I. Litmanovitch ◽  
H. Romanoff ◽  
Y. Pfeifer ◽  
...  
Keyword(s):  
Blood Components ◽  
Chronic Lymphedema

scholarly journals Spontaneous pancreatic pseudocyst–portal vein fistula: a rare and potentially life threatening complication of pancreatitis

2013 ◽  
Vol 95 (1) ◽  
pp. e7-e9 ◽  
Author(s):  
SS Raza ◽  
A Hakeem ◽  
M Sheridan ◽  
N Ahmad
Keyword(s):  
Chronic Pancreatitis ◽  
Portal Vein ◽  
Pancreatic Pseudocyst ◽  
Conservative Approach ◽  
Fatal Complication ◽  
Life Threatening ◽  
Life Threatening Complication ◽  
Acute And Chronic Pancreatitis ◽  
Pseudocyst Formation

Pseudocyst formation following acute and chronic pancreatitis is a well known complication. A pancreatic pseudocyst fistulating into the portal vein is a rare and potentially fatal complication. We report a case of pancreatic pseudocyst – portal vein fistula, which was managed with a conservative approach.

A RARE AND NEARLY FATAL COMPLICATION OF RHYTIDECTOMY

2004 ◽  
Vol 114 (1) ◽  
pp. 279-280 ◽  
Author(s):  
N. Jallali ◽  
B. G. H. Lamberty
Keyword(s):  
Fatal Complication
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