Sentinel lymph node nonvisualization after intratumoral radioisotope tracer injection in breast cancer is not associated with a higher nodal metastasis rate or worse outcomes

2018 ◽  
Vol 119 (4) ◽  
pp. 421-429 ◽  
Author(s):  
Daan Hellingman ◽  
Berlinda J de Wit-van der Veen ◽  
Oi Yan Wan ◽  
Iris M van der Ploeg ◽  
Emiel J. Th. Rutgers ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Nodal Metastasis ◽  
Tracer Injection ◽  
Metastasis Rate ◽  
Radioisotope Tracer

scholarly journals Preoperative Tumor Biopsy Results In More Detected Sentinel Node Than Intraoperative Biopsy In Breast Cancer Patients

2020 ◽  
Author(s):  
chenxi yuan ◽  
xinzhao wang ◽  
zhaoyun liu ◽  
chao li ◽  
mengxue bian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
False Negative ◽  
False Negative Rate ◽  
Excisional Biopsy ◽  
Breast Cancer Surgery ◽  
Tumor Biopsy ◽  
Tracer Injection ◽  
Negative Rate

Abstract Background Sentinel lymph node biopsy (SLNB) acts as a vital role in the breast cancer surgery, and the identified number of sentinel nodes determines its accuracy to represent the status of axillae. There remain two tumor biopsy modes in breast cancer, preoperative and intraoperative biopsy. We compared the effect of the two different biopsies on the result of SLNB. Methods Patients with clinical stage T1-3, N0 tumor were enrolled in this study. 53% received preoperative tumor biopsy and 47% received intraoperative excisional biopsy. For search of the sentinel lymph node, patients received dual tracer injection. The number of SLNs detected and false negative rate were compared between groups. Results 204 patients were enrolled, 108 received preoperative tumor biopsy and 96 received intraoperative excisional biopsy. Among all the patients, 160 received ALND following SLNB. Preoperative tumor biopsy detected more SLNs than intraoperative biopsy (mean rank 113.87 vs. 90.9, p= 0.004). False negative rate in preoperative and intraoperative tumor biopsy was 3% and 18%, respectively. Conclusions Patients in preoperative tumor biopsy group could find more SLNs than intraoperative biopsy patients. False negative rate was also lower in preoperative biopsy group.

scholarly journals Preoperative Tumor Biopsy Results In More Detected Sentinel Nodes Than Intraoperative Biopsy In Breast Cancer Patients

2020 ◽  
Author(s):  
chenxi yuan ◽  
xinzhao wang ◽  
zhaoyun liu ◽  
chao li ◽  
mengxue bian ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
False Negative ◽  
False Negative Rate ◽  
Excisional Biopsy ◽  
Tumor Biopsy ◽  
Tracer Injection ◽  
Sentinel Nodes ◽  
Negative Rate

Abstract Background Sentinel lymph node biopsy (SLNB) acts as a vital role in the breast cancer surgery, and the identified number of sentinel nodes determines its accuracy to represent the status of axillae. There remain two tumor biopsy modes in breast cancer, preoperative and intraoperative biopsy. We compared the effect of the two different biopsies on the result of SLNB. Methods Patients with clinical stage T1-3, N0 tumor were enrolled in this study. 53% received preoperative tumor biopsy and 47% received intraoperative excisional biopsy. For search of the sentinel lymph node, patients received dual tracer injection. The number of SLNs detected and false negative rate were compared between groups. Results 204 patients were enrolled, 108 received preoperative tumor biopsy and 96 received intraoperative excisional biopsy. Among all the patients, 160 received ALND following SLNB. Preoperative tumor biopsy detected more SLNs than intraoperative biopsy (mean rank 113.87 vs. 90.9, p= 0.004). False negative rate in preoperative and intraoperative tumor biopsy was 3% and 18%, respectively. Conclusions Patients in preoperative tumor biopsy group could find more SLNs than intraoperative biopsy patients. False negative rate was also lower in preoperative biopsy group.

Predictive Factors for Non-sentinel Nodal Metastasis in Patients With Sentinel Lymph Node-positive Breast Cancer

2020 ◽  
Vol 40 (8) ◽  
pp. 4405-4412 ◽  
Author(s):  
YUMIKO ISHIZUKA ◽  
YOSHIYA HORIMOTO ◽  
MEI NAKAMURA ◽  
ATSUSHI ARAKAWA ◽  
TOMOYUKI FUJITA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Predictive Factors ◽  
Nodal Metastasis ◽  
Node Positive ◽  
Lymph Node Positive ◽  
Positive Breast Cancer

scholarly journals Feasibility of preoperative 125I seed-guided tumoural tracer injection using freehand SPECT for sentinel lymph node mapping in non-palpable breast cancer

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Bas Pouw ◽  
Linda J de Wit-van der Veen ◽  
Daan Hellingman ◽  
Oscar R Brouwer ◽  
Marie-Jeanne TFD Vrancken Peeters ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Mapping ◽  
125I Seed ◽  
Tracer Injection ◽  
Lymph Node Mapping ◽  
Freehand Spect ◽  
Palpable Breast

Different Sites and Modes of Tracer Injection for Mapping the Sentinel Lymph Node in Patients with Breast Cancer

2000 ◽  
Vol 86 (4) ◽  
pp. 307-308 ◽  
Author(s):  
Pietro Bianchi ◽  
Giuseppe Villa ◽  
Ferdinando Buffoni ◽  
Giuseppe Agnese ◽  
Marco Gipponi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Tracer Particle ◽  
Lymphatic Vessels ◽  
Blue Dye ◽  
Radioguided Surgery ◽  
Tracer Injection ◽  
Vital Dye ◽  
Internal Mammary

Several studies have been published describing the techniques of identification of the “sentinel lymph node'’ (SN). There are marked differences in the techniques used by different investigators. Although agreement exists about the tracer particle size and the volume of injection, it is unknown what is the best site where to inject the tracer or the vital dye. The aim of the present study was to define the influence of different sites of injection on imaging of the lymphatic ducts and their SNs. We performed a pilot study in 30 consecutive patients with breast cancer who underwent SN biopsy by means of radioguided surgery and vital blue dye mapping. The patients were divided into six groups of five patients each; each patient was given a subdermal (ID) or peritumoral (IP) injection of radiotracer (300 μCi in 150 mL of 99mTc-HSA microcolloids; Albures, Amersham Sorin) above the tumor site in order to localize the SN. After the identification of the SN, a second injection of radiotracer was performed, which was different in each patient subset. In some cases more than one lymph node appeared on the lymphoscintigraphic scans after the second injection of radiotracer. When the peritumoral route was used it took longer to visualize the lymphatic pathways. For the ID route, injection at the exact skin projection over the tumor is optimal. Internal mammary lymph nodes were identified by both IP (2) and ID (1) injection, irrespective of the quadrant in which the tracer was injected. Our findings support the hypothesis of a precise topographic correspondence between the primary tumor and its specific SN. The subdermal route is more accurate than the intraparenchymal route, as it allows faster identification of the lymphatic vessels and SN. We believe these observations should be taken into account for the proper selection of the injection site of either vital dye or radiopharmaceuticals.

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