Does the number of sentinel lymph nodes removed affect the false negative rate for head and neck melanoma?

2018 ◽  
Vol 117 (7) ◽  
pp. 1584-1588 ◽  
Author(s):  
Charles J. Puza ◽  
Srirama Josyula ◽  
Alicia M. Terando ◽  
John H. Howard ◽  
Doreen M. Agnese ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Head And Neck ◽  
False Negative ◽  
False Negative Rate ◽  
Sentinel Lymph Nodes ◽  
Negative Rate ◽  
Head And Neck Melanoma

Do Primary Tumor Stage and Lymphatic Tumor Burden Affect the False Negative Rate of Sentinel Lymph Nodes in Colorectal Cancer?

2002 ◽  
Vol 8 (6) ◽  
pp. 484
Author(s):  
G. A. Broderick-Villa ◽  
A. S. Ko ◽  
T. X. OʼConnell ◽  
Joseph M. Guenther ◽  
L. A. DiFronzo
Keyword(s):  
Colorectal Cancer ◽  
Lymph Nodes ◽  
Primary Tumor ◽  
False Negative ◽  
False Negative Rate ◽  
Tumor Stage ◽  
Tumor Burden ◽  
Sentinel Lymph Nodes ◽  
Negative Rate

scholarly journals 489 The Role of Sentinel Lymph Node Biopsy in Cutaneous Head and Neck Melanoma: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
E Johnston ◽  
S Taylor ◽  
F Bannon ◽  
S McAllister
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Head And Neck ◽  
False Negative ◽  
False Negative Rate ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Negative Rate ◽  
Sentinel Node Identification

Abstract Introduction and Aims The aim of this systematic review is to provide an up-to-date evaluation of the role and test performance of sentinel lymph node biopsy (SLNB) in the head and neck. Method This review follows the PRISMA guidelines. Database searches for MEDLINE and EMBASE were constructed to retrieve human studies published between 1st January 2010 and 1st July 2020 assessing the role and accuracy of sentinel lymph node biopsy in cutaneous malignant melanoma of the head and neck. Articles were independently screened by two reviewers and critically appraised using the MINORS criteria. The primary outcomes consisted of the sentinel node identification rate and test-performance measures, including the false-negative rate and the posttest probability negative. Results A total of 27 studies, including 4688 patients, met the eligibility criteria. Statistical analysis produced weighted summary estimates for the sentinel node identification rate of 97.3% (95% CI, 95.9% to 98.6%), the false-negative rate of 21.3% (95% CI, 17.0% to 25.4%) and the posttest probability negative of 4.8% (95% CI, 3.9% to 5.8%). Discussion Sentinel lymph node biopsy is accurate and feasible in the head and neck. Despite technical improvements in localisation techniques, the false negative rate remains disproportionately higher than for melanoma in other anatomical sites.

Phantom study of SPECT/CT augmented reality for intraoperative localization of sentinel lymph nodes in head and neck melanoma

Oral Oncology ◽  
2022 ◽  
Vol 125 ◽  
pp. 105702
Author(s):  
Ryusuke Nakamoto ◽  
Jialin Zhuo ◽  
Kip E. Guja ◽  
Heying Duan ◽  
Stephanie L. Perkins ◽  
...  
Keyword(s):  
Augmented Reality ◽  
Lymph Nodes ◽  
Head And Neck ◽  
Sentinel Lymph Nodes ◽  
Phantom Study ◽  
Head And Neck Melanoma ◽  
Intraoperative Localization

Performance of a 31-gene expression profile (GEP) test for metastatic risk prediction in cutaneous melanomas (CM) of the head and neck.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 9576-9576
Author(s):  
John T. Vetto ◽  
Sancy Ann Leachman ◽  
Brooke Middlebrook ◽  
Kyle R. Covington ◽  
Jeffrey D. Wayne ◽  
...  
Keyword(s):  
High Risk ◽  
Head And Neck ◽  
Distant Metastasis ◽  
False Negative ◽  
Tumor Biology ◽  
False Negative Rate ◽  
Neck Region ◽  
Negative Rate ◽  
Class 1 ◽  
Metastatic Risk

9576 Background: Accurate prognostication of distant metastatic risk using sentinel lymph node (SLN) biopsy for CM can be challenging in melanomas of the head and neck due to a higher false negative rate compared to other anatomical areas. A GEP signature that predicts metastatic risk based on primary tumor biology, providing a binary outcome of Class 1 (low risk of metastasis) or Class 2 (high risk), was previously described. The prognostic capabilities of the GEP independently and in combination with SLN status in a cohort of patients with primary head and neck CM are assessed here. Methods: All samples and clinical data were collected under an IRB-approved multicenter protocol. qPCR analysis was used to assess expression of the gene signature (Class 1 vs. Class 2). Distant metastasis-free survival (DMFS) and melanoma-specific survival (MSS) were assessed. Results: 157 subjects with primary CMs in the head and neck region were identified. 110 of 157 subjects had a SLN biopsy performed. Median age was 65 years (range 25-89) and median Breslow depth was 1.6 mm (range 0.2-15.0 mm). In 71 SLN-negative patients, 18 of 27 (67%) distant metastatic events were GEP Class 2. Overall, 73% (47 of 64) distant metastases, and 88% (22 of 25) deaths due to CM were called Class 2. By comparison, sensitivities for DMFS and MSS were 41% (26 of 64) and 52% (13 of 25), respectively, using SLN biopsy alone, and increased to 80% (51 of 64) and 88% (22 of 25), respectively, when combining the SLN status and GEP class. Kaplan-Meier 5-year DMFS and MSS rates based on SLN status alone or in combination with GEP are shown in the table. Conclusions: These data support the ability of the GEP test to accurately identify low- and high-risk cases of head and neck melanoma. The results strongly support the role of GEP testing to enhance current staging by better predicting the risk of distant metastasis and death for patients with melanoma in an anatomic region that is associated with a higher SLN biopsy false negative rate. [Table: see text]

Effects of variation of sentinel lymph nodes submitted during breast cancer sugery: Analysis of practice variation and costs.

2014 ◽  
Vol 32 (30_suppl) ◽  
pp. 94-94 ◽  
Author(s):  
Louis H. Barr ◽  
Meiling Wu ◽  
Yai-Ping Mimi Shao ◽  
Xiang Zhu
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
False Negative ◽  
Sentinel Lymph Nodes ◽  
Lymph Node Status ◽  
Negative Number ◽  
Pathologic Evaluation ◽  
Negative Rate ◽  
Retrospective Examination

94 Background: Routine node evaluation involves simple bivalving the node with slides made from the resultant surfaces. SLNs are more thoroughly evaluated with 2-3 mm slices and histologic evaluation of each slice, resulting in many more slides to review. These slides would often have immunohistochemical analysis adding to the time and cost. In early studies of SLN efficacy and accuracy, the mean number of nodes was between 2 and 3 per patient though with some variation. As the number of submitted SLNs increases, the concern of benefit of the procedure comes into question. This is a retrospective examination of all SLN procedures for the year 2012 to examine the variation in the number of SLNs submitted for focused pathologic evaluation. Variation in the number of nodes submitted by surgeon is determined along with the associated costs of the pathologic evaluation. In addition, intraoperative evaluation of lymph node status may be useful to allow for immediate axillary node dissection during the initial operation. Utilization of this procedure was also examined to determine ultimate correlation with permanent pathologic evaluation. Methods: Retrospective examination of all breast cancer patients >=18 yrs who underwent SLN procedures during 2012. Introperative evaluation of lymph node for metastatic disease was also examined for correlation with permanent pathologic result. Results: 259 cases among 21 surgeons had touch prep performed. True positive number: 29. True negative number: 224. False negative number: 6. Fasle negative rate (FNR): 17.14%. Cost Effectiveness Evaluation: CPT 88307 - surg path gross and micro level V. CPT 88342 - Immunohistochemistry. CPT 88333 - Touch Prep. Pathologist time: 30 minutes per case. Conclusions: There is significant variation among surgeons as to number of cases and number of nodes submitted. There is a significantly greater number of sentinel lymph nodes examined by the pathologist as compared to the number of nodes submitted by the surgeon. The frequency of outliers is infrequent, but when it occurs there is significant cost in terms of time and dollars. The false negative rate from pathological evaluation is under study for isolated tumor cells.

Sign in / Sign up

Export Citation Format

Share Document