Prognostic significance of poorly differentiated clusters and tumor budding in colorectal liver metastases

2018 ◽  
Vol 117 (7) ◽  
pp. 1364-1375 ◽  
Author(s):  
Gilton M. Fonseca ◽  
Evandro S. de Mello ◽  
Sheila F. Faraj ◽  
Jaime A. P. Kruger ◽  
Fabricio F. Coelho ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Prognostic Significance ◽  
Tumor Budding ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated

Reply to “Poorly differentiated clusters in colorectal liver metastases: Prognostic significance in synchronous and metachronous metastases”

2018 ◽  
Vol 117 (8) ◽  
pp. 1858-1859
Author(s):  
Gilton M. Fonseca ◽  
Evandro S. de Mello ◽  
Fabricio F. Coelho ◽  
Jaime A.P. Kruger ◽  
Sheila F. Faraj ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Prognostic Significance ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated ◽  
Metachronous Metastases

scholarly journals Comment on Jun, S.Y.; et al. “Tumor Budding and Poorly Differentiated Clusters in Small Intestinal Adenocarcinoma” Cancers 2020, 12, 2199

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2982 ◽  
Author(s):  
Paolo Giuffrida ◽  
Giovanni Arpa ◽  
Alessandro Vanoli ◽  
Antonio Di Sabatino
Keyword(s):  
Tumor Budding ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated ◽  
Small Intestinal ◽  
Small Intestinal Adenocarcinoma

We read with interest the paper by Jun S [...]

scholarly journals Critical review of the prognostic significance of pathological variables in patients undergoing resection for colorectal liver metastases

HPB ◽  
2014 ◽  
Vol 16 (9) ◽  
pp. 836-844 ◽  
Author(s):  
Dhanwant Gomez ◽  
Abed M. Zaitoun ◽  
Antonella De Rosa ◽  
Sina Hossaini ◽  
Ian J. Beckingham ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Critical Review ◽  
Colorectal Liver Metastases ◽  
Prognostic Significance

scholarly journals Prognostic Factors Affecting Survival of Patients after Liver Resection Due to Colorectal Liver Metastases

2016 ◽  
Vol 70 (3) ◽  
pp. 133-139
Author(s):  
Stefan Petrovski ◽  
Elena Arabadzhieva ◽  
Saso Bonev ◽  
Dimitar Bulanov ◽  
Valentin Popov ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Liver Resection ◽  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Prognostic Significance ◽  
Radical Resection ◽  
University Hospital ◽  
Tumor Type ◽  
Term Survival ◽  
Localization Of Metastases

Abstract Introduction. Colorectal liver metastases have a poor prognosis and only 2% have an average 5-year survival if left untreated. In recent decades there has been a development in the diagnosis, treatment and palliative treatment of patients with colorectal liver metastases, and despite radical resection the average five-year survival is between 25% and 44%. Aim. To explore the experience of the Clinic in the treatment of colorectal liver metastases, comparing it with data from the literature and based on the comparison to determine the prognostic factors that affect survival after radical surgical treatment of patients. Methods. A retrospective study was conducted at the Clinic of General and Hepato-pancreatic Surgery at the University Hospital “Aleksandrovska”-Sofia. The study comprised the period between 01.01.2006 to 31.12.2015. It included a total of 239 cases, of whom: 179 patients underwent radical interventions, 5 palliative and 55 patients underwent explorative interventions due to liver metastases. Clinical and pathological materials were analyzed using SPSS-19 to determine the prognostic significance of a number of factors in relation to the survival: gender, age, type and localization of metastases, postoperative stage of the primary tumor, type and volume of liver resection, extrahepatic metastases, preoperative values of CEA, postoperative values (AST, ALT). Results. Factors that correlated with lower survival type: metastases (synchronous or metachronus), localization of metastases (uni-or bilobar), presence of the regional lymph node metastases and metastases to other distant organs and the impossibility of radical resection of liver were statistically significant with multivariant analysis. Elevated preoperative value of CEA, the value of hemoglobin and stage IV disease also affected the survival of patients. Conclusion. In patients with colorectal liver metastases only resection has potentially curative character. The surgical strategy for resection in context of increasing the percentage of patients with resectable potential is the only possible factor for long-term survival.

Prognostic Significance of Surgical Margin Size After Neoadjuvant FOLFOX and/or FOLFIRI for Colorectal Liver Metastases

2017 ◽  
Vol 21 (11) ◽  
pp. 1831-1840 ◽  
Author(s):  
Cynthia L. Miller ◽  
Martin S. Taylor ◽  
Motaz Qadan ◽  
Vikram Deshpande ◽  
Steven Worthington ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Prognostic Significance ◽  
Surgical Margin

Prognostic significance of CDX2 immunoexpression in poorly differentiated clusters of colorectal carcinoma

2017 ◽  
Vol 471 (6) ◽  
pp. 731-741 ◽  
Author(s):  
Luca Reggiani Bonetti ◽  
Simona Lionti ◽  
Enrica Vitarelli ◽  
Valeria Barresi
Keyword(s):  
Colorectal Carcinoma ◽  
Prognostic Significance ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated

scholarly journals Biological and Prognostic Significance of the Morphological Types and Vascular Patterns in Colorectal Liver Metastases (CRLM)

Medicine ◽  
2016 ◽  
Vol 95 (8) ◽  
pp. e2924 ◽  
Author(s):  
Pulathis N. Siriwardana ◽  
Tu Vinh Luong ◽  
Jennifer Watkins ◽  
Helen Turley ◽  
Mohamed Ghazaley ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Prognostic Significance
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