Gastrointestinal stromal tumors (GISTs) at uncommon locations: A large population based analysis

2015 ◽  
Vol 111 (6) ◽  
pp. 696-701 ◽  
Author(s):  
Moshim Kukar ◽  
Aditi Kapil ◽  
Wesley Papenfuss ◽  
Adrienne Groman ◽  
Stephen R. Grobmyer ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Large Population ◽  
Population Based ◽  
Stromal Tumors

Long-term Survival among Patients with Gastrointestinal Stromal Tumors Diagnosed after Another Malignancy: A SEER Population-Based Study

2020 ◽  
Author(s):  
Chaoyong Shen ◽  
Chengshi Wang ◽  
Tao He ◽  
Zhaolun Cai ◽  
Xiaonan Yin ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Population Based ◽  
Clinicopathological Characteristics ◽  
Second Primary ◽  
Primary Malignancy ◽  
Clinicopathologic Characteristics ◽  
Term Survival ◽  
Stromal Tumors ◽  
Group A

Abstract BACKGROUND: To explore overall survival (OS) and GISTs-specific survival (GSS) among cancer survivors developing a second primary gastrointestinal stromal tumors (GISTs). METHODS: We conducted a cohort study, where patients with GISTs after another malignancy (AM-GISTs, n=851) and those with only GISTs (GISTs-1, n=7660) were identified from the Surveillance, Epidemiology, End Results registries (1988-2016). Clinicopathologic characteristics and survival were compared between the two groups. RESULTS: The most commonly diagnosed first primary malignancy was prostate cancer (27.7%), followed by breast cancer (16.2%). OS among AM-GISTs was significantly inferior to that of GISTs-1: 10-year OS was 40.3% vs. 50.0%, (p<0.001); A contrary finding was observed for GSS (10-year GSS: 68.9% vs. 61.8%, p=0.002). In the AM-GISTs group, a total of 338 patients died, of which 26.0% died of their initial cancer and 40.8% died of GISTs. Independent of demographics and clinicopathological characteristics, mortality from GISTs among AM-GISTs patients was decreased compared with their GISTs-1 counterparts (HR, 0.71; 95% CI, 0.59-0.84; p<0.001); whereas OS was inferior among AM-GISTs (HR, 1.11; 95% CI, 0.99-1.25; p=0.085). CONCLUSIONS: AM-GISTs patients have decreased risk of dying from GISTs compared with GIST-1. Although another malignancy history does not seemingly affect OS for GISTs patients, clinical treatment of such patients should be cautious.

scholarly journals Establishment and Verification of Synchronous Metastatic Nomogram for Gastrointestinal Stromal Tumors (GISTs): A Population-Based Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Yuqiang Li ◽  
Guangfeng Zhang ◽  
Xiangping Song ◽  
Lilan Zhao ◽  
Cenap Güngör ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Gastrointestinal Stromal Tumors ◽  
Logistic Regression Model ◽  
Validation Cohort ◽  
Tumor Location ◽  
Population Based ◽  
Brier Score ◽  
Validation Group ◽  
Synchronous Metastasis ◽  
Stromal Tumors

Aim. Assess the risk of synchronous metastasis and establish a nomogram in patients with GISTs. Methods. Surveillance, Epidemiology and End Results database (2004-2014) was accessed. With the logistic regression model as the basis, a nomogram was constructed. Results. 7,256 target patients were contained in our study. The nomogram discrimination for mGIST prediction revealed that tumor size contributed most to synchronous metastasis, followed by lymph nodes, extension, pathologic grade, tumor location, and mitotic count. C-index values of predictions were 0.821 (95% CI, 0.805-0.836) and 0.815 (95% CI, 0.800-0.831), and Brier score were 0.109 and 0.112 in training and validation group, respectively. The value of area under the ROCs were 0.813 (p<0.001) in the primary cohort and 0.819 (p<0.001) in the validation cohort. Through the calibration curves (as seen in the figures), nomogram prediction proved to have excellent agreement with actual metastatic diseases. Conclusion. A new nomogram was created that can evaluate synchronous metastatic diseases in patients with GISTs.

scholarly journals KIT and PDGFRα mutations in 104 patients with gastrointestinal stromal tumors (GISTs): a population-based study

2008 ◽  
Vol 19 (4) ◽  
pp. 706-710 ◽  
Author(s):  
C. Braconi ◽  
R. Bracci ◽  
I. Bearzi ◽  
F. Bianchi ◽  
A. Costagliola ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Population Based ◽  
Population Based Study ◽  
Stromal Tumors

scholarly journals Incidence and clinicopathologic features of gastrointestinal stromal tumors. A population-based study

BMC Cancer ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Claudia Mucciarini ◽  
Giulio Rossi ◽  
Federica Bertolini ◽  
Riccardo Valli ◽  
Claudia Cirilli ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Population Based ◽  
Clinicopathologic Features ◽  
Population Based Study ◽  
Stromal Tumors

scholarly journals Incidence and Survival Analysis of Gastrointestinal Stromal Tumors in Shanghai: A Population-Based Study from 2001 to 2010

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Minzhi Lv ◽  
Chunxiao Wu ◽  
Ying Zheng ◽  
Naiqing Zhao
Keyword(s):  
Overall Survival ◽  
Gastrointestinal Stromal Tumors ◽  
Cox Regression ◽  
Population Based ◽  
Cox Proportional Hazards ◽  
Male Gender ◽  
Older Age ◽  
Population Based Study ◽  
Cox Regression Analysis ◽  
Stromal Tumors

Objectives.A population-based study was undertaken to investigate the epidemiological features of gastrointestinal stromal tumors (GISTs) in Shanghai, especially the incidence and the preliminary exploration of survival.Methods.A total of 1923 patients with GISTs diagnosed from 2001 to 2010 in Shanghai were reviewed. The annual incidence and overall survival of GISTs were calculated; Cox proportional hazards’ regression was used to analyze several prognostic factors.Results.The average crude incidence of GISTs was 2.11 per 100,000 between 2004 and 2008, and the age-standardized incidence was 1.28 per 100,000. The incidence increased gradually from 2004 to 2008. In addition, 57% of cases had GIST in the stomach and 33% in the intestine. The 5-year overall survival of GISTs was 86.98%. The Cox regression analysis showed older age (≥65 yr versus <40 yr, HR = 5.085; (40, 65) yr versus <40 yr, HR = 1.975), male gender (HR = 1.474), and tumor locations (intestinal versus stomach, HR = 1.609) were predictors of its mortality.Conclusion.GISTs, mainly occurring in the stomach, are more common in elderly population, with an increasing incidence from 2004 to 2008. Older age, male gender, and tumor locations are risk factors for its mortality.

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