The role of fibrin glue instillation under skin flaps in the prevention of seroma formation and related morbidities following breast and axillary surgery for breast cancer: A meta-analysis

2012 ◽  
Vol 106 (6) ◽  
pp. 783-795 ◽  
Author(s):  
Muhammad S. Sajid ◽  
Kristian Hutson ◽  
Lorain Kalra ◽  
Riccardo Bonomi
Keyword(s):  
Breast Cancer ◽  
Fibrin Glue ◽  
Meta Analysis ◽  
Seroma Formation ◽  
Skin Flaps ◽  
Axillary Surgery

scholarly journals Flap fixation in preventing seroma formation after mastectomy: an updated meta-analysis

2021 ◽  
Author(s):  
Nunzio Velotti ◽  
Gennaro Limite ◽  
Antonio Vitiello ◽  
Giovanna Berardi ◽  
Mario Musella
Keyword(s):  
Meta Analysis ◽  
Seroma Formation ◽  
Secondary Outcome ◽  
Axillary Lymph ◽  
Breast Cancer Patients ◽  
Inclusion Criteria ◽  
Effective Technique ◽  
Strong Evaluation ◽  
Flap Fixation

AbstractSeroma formation following mastectomy is one of the most experienced complications, with a very variable incidence ranging from 3 to 90%. In recent years, many publications have been realized to define an effective technique to prevent its formation and several approaches have been proposed. Given the potential of flap fixation in reducing seroma formation, we performed a meta-analysis of the literature to investigate the role of this approach as definitive gold standard in mastectomy surgery. Inclusion criteria regarded all studies reporting on breast cancer patients undergoing mastectomy with or without axillary lymph node dissection; studies that compared mastectomy with flap fixation to mastectomy without flap fixation were selected. Papers were eligible for inclusion if outcome was described in terms of seroma formation. As secondary outcome, also surgical site infection (SSI) was evaluated. The included studies were 12, involving 1887 female patients: 221/986 (22.41%) patients experienced seroma formation after flap fixation and 393/901 (43.61%) patients had this complication not receiving flap fixation, with a significant statistical difference between the two groups (OR = 0.267, p = 0.001, 95% CI 0.153, 0.464). About, SSI 59/686 (8.6%) in flap fixation group and 67/686 (9.7%) in patients without flap fixation, with no statistical differences between groups (OR = 0.59, p = 0.056, 95% CI 0.344, 1.013).The heterogeneity between included studies does not allow us to reach definitive conclusions but only to suggest the strong evaluation of this approach after mastectomy in seroma preventing and SSI reduction.

Prognostic role of s-phase kinase-associated protein 2 in breast cancer: A meta-analysis

2015 ◽  
Vol 52 (7) ◽  
pp. 153
Author(s):  
S Ma ◽  
D Wang ◽  
Y Shi ◽  
N Li ◽  
H Ren ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Meta Analysis ◽  
S Phase ◽  
Prognostic Role

scholarly journals Platinum-based neoadjuvant chemotherapy for triple-negative breast cancer: a systematic review and meta-analysis

2020 ◽  
Vol 48 (10) ◽  
pp. 030006052096434
Author(s):  
Zhen-Yu Li ◽  
Zhen Zhang ◽  
Xiao-Zhong Cao ◽  
Yun Feng ◽  
Sha-Sha Ren
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Meta Analysis ◽  
Complete Response ◽  
Extensive Literature ◽  
Extensive Literature Search ◽  
Positive Breast Cancer

Background Triple-negative breast cancer (TNBC) is associated with higher aggressiveness and mortality than hormone-positive breast cancer because of the lack of approved therapeutic targets. Patients with TNBC who attain a pathological complete response (pCR) after neoadjuvant chemotherapy have improved survival. Platinum-based agents show promising activity in TNBC; however, their use remains controversial. We conducted a meta-analysis to assess the role of platinum-based agents in neoadjuvant chemotherapy in patients with TNBC. Methods We performed an extensive literature search of the Pubmed, Embase, and Cochrane databases. We calculated pooled odds ratios (OR) with 95% confidence intervals (CI) for the identified studies. Results Eight randomized controlled trials with 1345 patients were included in the analysis. The addition of platinum-based agents improved pCR compared with neoadjuvant therapy based on anthracyclines, cyclophosphamide, taxanes, and fluorouracil (49.1% vs. 35.9%; OR: 1.87, 95% CI: 1.23–2.86). Hematological adverse events were similar in both groups, except for more thrombocytopenia in the platinum-based group (OR: 7.96, 95% CI: 3.18–19.93). Conclusion The addition of platinum-based agents to neoadjuvant chemotherapy improved pCR rates in patients with TNBC, with a slight increase in hematological toxicities. Platinum-based agents might thus be an accessible and economically viable option in patients with TNBC.

Does the use of fibrin glue prevent seroma formation after axillary lymphadenectomy for breast cancer? A prospective randomized trial in 159 patients

2010 ◽  
Vol 101 (7) ◽  
pp. 600-603 ◽  
Author(s):  
Calogero Cipolla ◽  
Salvatore Fricano ◽  
Salvatore Vieni ◽  
Giuseppa Graceffa ◽  
Gaspare Licari ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Randomized Trial ◽  
Fibrin Glue ◽  
Seroma Formation ◽  
Prospective Randomized Trial ◽  
Axillary Lymphadenectomy

The prognostic role of circulating tumor cells (CTCs) detected by RT-PCR in breast cancer: a meta-analysis of published literature

2011 ◽  
Vol 130 (3) ◽  
pp. 809-816 ◽  
Author(s):  
Shu Zhao ◽  
Yupeng Liu ◽  
Qingyuan Zhang ◽  
Hongbin Li ◽  
Minghui Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Meta Analysis ◽  
Rt Pcr ◽  
Prognostic Role

Role of Menopause and Early Menarche in Breast Cancer: A Meta-Analysis of Iranian Studies

2016 ◽  
Vol In press (In press) ◽  
Author(s):  
Bibi Hajar Zahmatkesh ◽  
Afsaneh Keramat ◽  
Nasrinossadat Alavi ◽  
Ahmad Khosravi ◽  
Reza Chaman
Keyword(s):  
Breast Cancer ◽  
Meta Analysis ◽  
Early Menarche ◽  
Iranian Studies

Circulating tumor cells in breast cancer

2017 ◽  
Vol 2 (1) ◽  
pp. 4 ◽  
Author(s):  
Akhil Jain ◽  
Moushumi Suryavanshi ◽  
Ullas Batra ◽  
Pankaj Goyal ◽  
Dinesh Doval
Keyword(s):  
Breast Cancer ◽  
Clinical Trials ◽  
Metastatic Breast Cancer ◽  
Tumor Cells ◽  
Meta Analysis ◽  
Metastatic Breast ◽  
Predictive Marker ◽  
Serum Markers ◽  
Ultimate Outcome

<span>Breast cancer is a heterogeneous disease. Liquid biopsy is a novel diagnostic tool and may provide answers to many questions related to unevenness in prognosis and ultimate outcome. Different technologies for CTC isolation, enrichment, detection, and characterization are under evaluation. Various clinical trials and meta-analysis have been conducted to define the role of CTC in early and metastatic breast cancer. CTCs are superior to other serum markers for prognostication. Their role as predictive marker remains elusive.</span>

The role of LHRH agonists in ovarian function preservation in premenopausal women undergoing chemotherapy for early stage breast cancer: A systematic review and meta-analysis.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 1050-1050
Author(s):  
Rodrigo Ramella Munhoz ◽  
Allan Andresson Lima Pereira ◽  
Andre Deeke Sasse ◽  
Paulo Marcelo Hoff ◽  
Tiffany A. Traina ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Ovarian Function ◽  
Early Stage ◽  
Meta Analysis ◽  
Premenopausal Women ◽  
Early Stage Breast Cancer ◽  
Lhrh Agonists ◽  
Function Preservation
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