scholarly journals Lymph node ratio is an important and independent prognostic factor for patients with stage III melanoma

2011 ◽  
Vol 105 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Adam C. Berger ◽  
Michael Fierro ◽  
John C. Kairys ◽  
David Berd ◽  
Takami Sato ◽  
...  
Keyword(s):  
Lymph Node ◽  
Prognostic Factor ◽  
Lymph Node Ratio ◽  
Independent Prognostic Factor ◽  
Stage Iii ◽  
Node Ratio ◽  
Stage Iii Melanoma

scholarly journals Lymph Node Ratio: Is It an Independent Prognostic Factor for Stage III Cutaneous Melanoma?

2018 ◽  
Vol 19 (12) ◽  
pp. 3623-3627
Author(s):  
Abolfazl Salari ◽  
Fatemeh Nili ◽  
Amir Mohsen Jalaeefar ◽  
Mohammad Shirkhoda
Keyword(s):  
Lymph Node ◽  
Prognostic Factor ◽  
Cutaneous Melanoma ◽  
Lymph Node Ratio ◽  
Independent Prognostic Factor ◽  
Stage Iii ◽  
Node Ratio

LODDS is Superior to Lymph Node Ratio for the Prognosis of Node-positive Rectal Cancer Patients Treated with Preoperative Radiotherapy

2016 ◽  
Vol 103 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Ben Huang ◽  
Mengdong Ni ◽  
Chen Chen ◽  
Guoxiang Cai ◽  
Sanjun Cai
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Cancer Patients ◽  
Lymph Node Ratio ◽  
Preoperative Radiotherapy ◽  
Independent Prognostic Factor ◽  
Stage Iii ◽  
Seer Database ◽  
Node Ratio

Purpose Yielding pathologic-lymph node ratio (yp-LNR) was considered to be a better staging system than yp-N stage in rectal cancer patients treated with preoperative radiotherapy (pre-RT). We aimed to compare the predictive ability of yielding pathologic log odds of positive lymph nodes (yp-LODDS) with that of yp-LNR for cancer-specific survival (CSS) in stage III rectal cancer patients treated with pre-RT. Methods We analyzed stage III rectal cancer patients treated with pre-RT in the Surveillance, Epidemiology and End Results (SEER) database. Patients were classified into 4 groups, yp-LNR1 to 4, based on the LNR cutoff points 0.25, 0.50, and 0.75. Subjects were categorized into 5 groups, yp-LODDS1 to yp-LODDS5, based on the LODDS cutoff points −1, 0, 1, and 2. Univariate and multivariate Cox proportional hazards models were performed to analyze the risk factors for survival outcome. Results A total of 4,612 patients were included from the SEER database. Patients in the yp-LNR4 group could be further divided into yp-LODDS4 and yp-LODDS5 groups with 5-year CSS of 47.6% and 31.5%, respectively (p<0.001). In the multivariate analysis without yp-LODDS, yp-LNR was an independent prognostic factor (hazard ratio [HR] 2.006, 95% confidence interval [CI] 1.619-2.484, p<0.001). However, after adjusting for yp-LODDS, yp-LNR was no longer associated with CSS (p = 0.393), and yp-LODDS was identified as an independent prognostic factor (HR 1.274, 95% CI 1.069-1.520, p = 0.007). Conclusions The prognostic value of yp-LNR can be confounded by yp-LODDS. In stage III rectal cancer patients treated with pre-RT, yp-LODDS has superior discrimination power over yp-LNR and can more accurately evaluate CSS.

Lymph node ratio is an independent prognostic factor for rectal cancer after neoadjuvant therapy: A meta-analysis

2018 ◽  
Vol 11 (3) ◽  
pp. 169-175 ◽  
Author(s):  
Chengwu Jin ◽  
Xiangbing Deng ◽  
Yan Li ◽  
Wanbin He ◽  
Xuyang Yang ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Neoadjuvant Therapy ◽  
Lymph Node Ratio ◽  
Meta Analysis ◽  
Independent Prognostic Factor ◽  
Node Ratio

scholarly journals Study of Survival in Gastric Cancer with Emphasis on Lymph Node Status as an Independent Prognostic Factor

2019 ◽  
Vol 4 (4) ◽  
pp. 185-189
Author(s):  
Nicolae Suciu ◽  
Orsolya Bauer ◽  
Zalán Benedek ◽  
Radu Ghenade ◽  
Marius Coroș ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Lymph Nodes ◽  
Vascular Invasion ◽  
Lymph Node Ratio ◽  
Independent Prognostic Factor ◽  
Lymph Node Status ◽  
Node Ratio ◽  
Gastric Cancer Patients

Abstract Background: Lymph node status in gastric cancer is known as an independent prognostic factor that guides the surgical and oncological treatment and independently influences long-term survival. Several studies suggest that the lymph node ratio has a greater importance in survival than the number of metastatic lymph nodes. Aim: The aim of this study was to evaluate the clinical and morphological factors that can influence the survival of gastric cancer patients, with an emphasis on nodal status and the lymph node ratio. Material and methods: We conducted a retrospective study in which 303 patients with gastric cancer admitted to the Department of Surgery of the Mureș County Hospital between 2008 and 2018 were screened for study enrolment. Data were obtained from the records of the department and from the histopathological reports. The examined variables included: age, gender, tumor localization, T stage, histological type, grade of differentiation, surgical procedure, lympho-vascular invasion, excised lymph nodes, metastatic lymph nodes, lymph node ratio. After screening, the study included a total number of 100 patients, for which follow-up data was available. Results: The mean age of the study population was 66.43 ± 10 years, and 71% were males. The average survival period was 21.42 months. Statistical analysis showed that the localization of the tumor (p = 0.021), vascular invasion (p ---lt---0.001), T (p = 0.004) and N (p ---lt---0.001) stages, type of surgery (partial gastrectomy 59% vs. total gastrectomy 41%, p = 0.005), as well as the lymph node ratio (p ---lt---0.001) were prognostic factors for survival in patients with gastric cancer undergoing surgical therapy. Conclusions: The survival of gastric cancer patients is significantly influenced by tumor localization, T stage, vascular invasion, type of surgery, N stage and the lymph node ratio based on univariate analysis. Also, the lymph node ratio proved to be an independent prognostic factor for survival.

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