L1 Cell adhesion molecule (L1CAM) expression at the cancer invasive front is a novel prognostic marker of pancreatic ductal adenocarcinoma

2011 ◽  
Vol 103 (7) ◽  
pp. 669-673 ◽  
Author(s):  
Shinji Tsutsumi ◽  
Satoko Morohashi ◽  
Yasuyuki Kudo ◽  
Harue Akasaka ◽  
Hiroshi Ogasawara ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Prognostic Marker ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Ductal Adenocarcinoma ◽  
Invasive Front ◽  
L1 Cell Adhesion Molecule ◽  
L1cam Expression

scholarly journals L1 Cell Adhesion Molecule (L1CAM) expression in endometrioid endometrial carcinomas: A possible pre-operative surrogate of lymph vascular space invasion

PLoS ONE ◽  
2018 ◽  
Vol 13 (12) ◽  
pp. e0209294 ◽  
Author(s):  
Daniela de Freitas ◽  
Fernando Nalesso Aguiar ◽  
Cristina Anton ◽  
Carlos Eduardo Bacchi ◽  
Jesus Paula Carvalho ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Vascular Space ◽  
Endometrial Carcinomas ◽  
L1 Cell Adhesion Molecule ◽  
L1cam Expression ◽  
Vascular Space Invasion

scholarly journals Clinical significance and biological role of L1 cell adhesion molecule in gastric cancer

2019 ◽  
Vol 121 (12) ◽  
pp. 1058-1068 ◽  
Author(s):  
Takashi Ichikawa ◽  
Yoshinaga Okugawa ◽  
Yuji Toiyama ◽  
Koji Tanaka ◽  
Chengzeng Yin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Tumour Progression ◽  
Disease Free Survival ◽  
Prognostic Impact ◽  
Fresh Frozen ◽  
L1 Cell Adhesion Molecule ◽  
L1cam Expression

Abstract Background L1 cell adhesion molecule (L1CAM) is highly expressed in malignant tumours and might play a pivotal role in tumour progression. Methods We analysed by immunohistochemistry L1CAM protein expression in formalin-fixed, paraffin-embedded specimens from 309 GC patients. We performed propensity score matching (PSM) analysis to clarify the prognostic impact of L1CAM in GC patients. We evaluated L1CAM gene expression in fresh frozen specimens from another group of 131 GC patients to establish its clinical relevance. The effects of changes in L1CAM were investigated in vitro and in vivo. Results L1CAM was mainly expressed in tumour cells of GC tissues. Elevated L1CAM expression was an independent prognostic factor for overall and disease-free survival, and an independent risk factor for distant metastasis in GC patients. PSM analysis showed that high L1CAM expression was significantly associated with poor prognosis. L1CAM gene expression using fresh frozen specimens successfully validated all of these findings in an independent cohort. Inhibition of L1CAM suppressed cell proliferation, cycle progress, invasion, migration and anoikis resistance in GC cells. Furthermore, L1CAM inhibition suppressed the growth of peritoneal metastasis. Conclusion L1CAM may serve as a feasible biomarker for identification of patients who have a high risk of recurrence of GC.

scholarly journals Immunohistochemical Expression of “L1 cell Adhesion Molecule” in Endometrial Carcinomas

2020 ◽  
Vol 8 (A) ◽  
pp. 113-118
Author(s):  
Aya Magdy Elyamany ◽  
Solafa Amin Abd-ElAziz ◽  
Samar A. Elsheikh ◽  
Somia A. M. Soliman
Keyword(s):  
Endometrial Cancer ◽  
Cell Adhesion ◽  
High Risk ◽  
Endometrial Carcinoma ◽  
Adhesion Molecule ◽  
Therapeutic Target ◽  
Cell Adhesion Molecule ◽  
Endometrial Carcinomas ◽  
L1 Cell Adhesion Molecule ◽  
L1cam Expression

BACKGROUND: Endometrial cancer is the most common cancer of the female genital tract. No effective biomarkers currently exist to allow for an efficient risk classification of endometrial carcinoma or to direct treatment (adjuvant radiation and/or chemotherapy) or to triage pelvic and para-aortic lymphadenectomy. L1 cell adhesion molecule (L1CAM) a transmembrane protein of the immunoglobulin family that has been implicated in promoting tumor cell proliferation, migration, invasion, and metastasis became an attractive candidate as a potential biomarker in endometrial carcinoma and potential therapeutic target in high-risk groups. OBJECTIVES: Evaluation of L1CAM expression in endometrial carcinoma and correlation of this expression with various pathological parameters. MATERIALS AND METHODS: Immunohistochemical staining for L1CAM was performed on paraffin-embedded sections of 80 cases of endometrial carcinomas that underwent total hysterectomy with bilateral salpingo-oophorectomy. Expression of L1CAM in >10% of tumor cells was interpreted as positive. RESULTS: L1CAM expression was detected in 22.5% of cases and showed statistically significant correlation with non-endometrioid histological type, high grade, high FIGO stage, high pathological (T) stage, cervical involvement, nodal metastasis, lymphovascular space invasion, and high-risk tumor according to the European Society for Medical Oncology system for risk stratification (p < 0.05). CONCLUSION: The high rate of L1CAM expression in high-risk endometrial carcinomas suggests that L1CAM represents a potential marker for the identification of patients needing closer follow-up and aggressive treatment. In addition, its potential role as a therapeutic target for high-risk endometrial cancer seems promising.

scholarly journals Expression of L1 Cell Adhesion Molecule and Morphologic Features at the Invasive Front of Colorectal Cancer

2011 ◽  
Vol 136 (1) ◽  
pp. 138-144 ◽  
Author(s):  
Yoshiki Kajiwara ◽  
Hideki Ueno ◽  
Yojiro Hashiguchi ◽  
Eiji Shinto ◽  
Hideyuki Shimazaki ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Invasive Front ◽  
L1 Cell Adhesion Molecule

scholarly journals Semaphorin3D Regulates Axon Axon Interactions by Modulating Levels of L1 Cell Adhesion Molecule

2007 ◽  
Vol 27 (36) ◽  
pp. 9653-9663 ◽  
Author(s):  
M. A. Wolman ◽  
A. M. Regnery ◽  
T. Becker ◽  
C. G. Becker ◽  
M. C. Halloran
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
L1 Cell Adhesion Molecule
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