Lymph node ratio as determined by the 7th edition of the American Joint Committee on Cancer staging system predicts survival in stage III colon cancer

2010 ◽  
Vol 103 (5) ◽  
pp. 406-410 ◽  
Author(s):  
Kwang Dae Hong ◽  
Sun Il Lee ◽  
Hong Young Moon
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Staging System ◽  
Cancer Staging ◽  
Stage Iii ◽  
Stage Iii Colon Cancer ◽  
7Th Edition ◽  
American Joint Committee ◽  
Node Ratio

The lymph node ratio does not provide additional prognostic information compared with the N1/N2 classification in Stage III colon cancer

2017 ◽  
Vol 19 (2) ◽  
pp. 165-171 ◽  
Author(s):  
H. M. Mohan ◽  
C. Walsh ◽  
R. Kennelly ◽  
C. H. Ng ◽  
P. R. O'Connell ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Stage Iii ◽  
Prognostic Information ◽  
Stage Iii Colon Cancer ◽  
Node Ratio

Lymph Node Ratio as a Quality and Prognostic Indicator in Stage III Colon Cancer

2011 ◽  
Vol 253 (1) ◽  
pp. 82-87 ◽  
Author(s):  
Steven L Chen ◽  
Scott R. Steele ◽  
John Eberhardt ◽  
Kangmin Zhu ◽  
Anton Bilchik ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Prognostic Indicator ◽  
Stage Iii ◽  
Stage Iii Colon Cancer ◽  
Node Ratio

Proposal of New Classification for Stage III Colon Cancer Based on the Lymph Node Ratio: Analysis of 4,172 Patients from Multi-Institutional Database in Japan

2014 ◽  
Vol 22 (2) ◽  
pp. 528-534 ◽  
Author(s):  
Kiichi Sugimoto ◽  
Kazuhiro Sakamoto ◽  
Yuichi Tomiki ◽  
Michitoshi Goto ◽  
Kenjiro Kotake ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Stage Iii ◽  
Ratio Analysis ◽  
New Classification ◽  
Stage Iii Colon Cancer ◽  
Node Ratio

scholarly journals A Lymph Node Ratio of 10% Is Predictive of Survival in Stage III Colon Cancer: A French Regional Study

2014 ◽  
Vol 99 (4) ◽  
pp. 344-353 ◽  
Author(s):  
Charles Sabbagh ◽  
François Mauvais ◽  
Cyril Cosse ◽  
Lionel Rebibo ◽  
Jean-Paul Joly ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Lymph Nodes ◽  
Lymph Node Ratio ◽  
Disease Free Survival ◽  
Stage Iii ◽  
Stage Iii Colon Cancer ◽  
Node Ratio

Abstract Lymph node ratio (LNR) (positive lymph nodes/sampled lymph nodes) is predictive of survival in colon cancer. The aim of the present study was to validate the LNR as a prognostic factor and to determine the optimum LNR cutoff for distinguishing between “good prognosis” and “poor prognosis” colon cancer patients. From January 2003 to December 2007, patients with TNM stage III colon cancer operated on with at least of 3 years of follow-up and not lost to follow-up were included in this retrospective study. The two primary endpoints were 3-year overall survival (OS) and disease-free survival (DFS) as a function of the LNR groups and the cutoff. One hundred seventy-eight patients were included. There was no correlation between the LNR group and 3-year OS (P = 0.06) and a significant correlation between the LNR group and 3-year DFS (P = 0.03). The optimal LNR cutoff of 10% was significantly correlated with 3-year OS (P = 0.02) and DFS (P = 0.02). The LNR was not an accurate prognostic factor when fewer than 12 lymph nodes were sampled. Clarification and simplification of the LNR classification are prerequisites for use of this system in randomized control trials. An LNR of 10% appears to be the optimal cutoff.

scholarly journals Significance of the Lymph Node Ratio in Stage III Colon Cancer

2008 ◽  
Vol 15 (6) ◽  
pp. 1557-1558 ◽  
Author(s):  
Simon H. Telian ◽  
Anton J. Bilchik
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Stage Iii ◽  
Stage Iii Colon Cancer ◽  
Node Ratio

A novel simplified approach to incorporating lymph node ratio into gastric cancer staging.

2013 ◽  
Vol 31 (4_suppl) ◽  
pp. 24-24
Author(s):  
Sarah B. Fisher ◽  
Malcolm Hart Squires ◽  
Sameer H. Patel ◽  
David A. Kooby ◽  
Kenneth Cardona ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Staging System ◽  
Cancer Staging ◽  
Lymph Node Staging ◽  
Cox Regression Analysis ◽  
Simplified Approach ◽  
Staging Systems ◽  
Node Ratio

24 Background: Previous investigators have reported on the value of lymph node ratio (LNR, defined as the number of positive nodes divided by the total number of nodes assessed) in gastric adenocarcinoma (GAC) staging. Given the complexity of previously proposed staging systems, it has not gained widespread acceptance. The aim of our study was to offer a novel simplified approach to incorporating LNR into gastric cancer staging. Methods: 131 patients who underwent curative intent resection with lymphadenectomy for GAC between 1/00-6/11 were identified. Clinicopathologic factors were assessed. Primary outcome was overall survival (OS). Results: Median age was 64 yrs, 51% were male. Median tumor size was 3.5 cm, 67% were poorly differentiated, 20% had perineural invasion, 31% had lymphovascular invasion, and 6% had a positive margin. Locoregional nodal metastases were present in 59% (n=77, N0: 41%, N1: 18%, N2: 22%, N3a: 14%, N3b: 5%). Median number of lymph nodes (LN) assessed was 15.5. Mean FU was 27.3 mos, median OS was 29.3 mos. Median LNR was 0.4 (.04-1). Patients with LNR ≥0.4 had decreased OS as compared to patients with LNR <0.4 (15.1 vs 41.5 mos, p<0.0001); the survival of patients with LNR <0.4 was similar to that of node negative pts (48 mos, p=0.882). On Cox regression analysis, LNR ≥0.4 was more strongly associated with decreased OS (HR 3.09, 95%CI: 1.81-5.26; p<0.0001) compared to the AJCC 7th edition N stage (HR 1.36, 95%CI: 1.11-1.68; p=0.004). In the subset of patients who were inadequately staged and had <16 nodes examined, a LNR ≥0.4 was associated with reduced survival compared to a LNR <0.4 (17.3 vs 41.5 mos, p=.04). Conclusions: Compared to the current lymph node staging system, a lymph node ratio using 0.4 as the cutoff may more accurately predict survival outcomes. It seems to be particularly useful in patients who have inadequate nodal assessment. This simplified approach to lymph node ratio may be a more valuable staging tool than the current AJCC nodal staging system for gastric cancer and needs to be validated.

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