Hepatocellular carcinoma with a central scar and a scalloped tumor margin resembling focal nodular hyperplasia in macroscopic appearance

2006 ◽  
Vol 94 (7) ◽  
pp. 587-591 ◽  
Author(s):  
Masakazu Yamamoto ◽  
Shyunichi Ariizumi ◽  
Kenji Yoshitoshi ◽  
Akiko Saito ◽  
Masayuki Nakano ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Focal Nodular Hyperplasia ◽  
Macroscopic Appearance ◽  
Central Scar ◽  
Tumor Margin ◽  
Nodular Hyperplasia

scholarly journals Differential Diagnosis of Hepatic Mass with Central Scar: Focal Nodular Hyperplasia Mimicking Fibrolamellar Hepatocellular Carcinoma

Diagnostics ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 44
Author(s):  
Teodoro Rudolphi-Solero ◽  
Eva María Triviño-Ibáñez ◽  
Antonio Medina-Benítez ◽  
Javier Fernández-Fernández ◽  
Daniel José Rivas-Navas ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Differential Diagnosis ◽  
Focal Nodular Hyperplasia ◽  
Radical Surgery ◽  
Fibrolamellar Hepatocellular Carcinoma ◽  
Central Scar ◽  
Hepatic Mass ◽  
Contrast Enhanced Ct ◽  
Pet Ct ◽  
Nodular Hyperplasia

Fibrolamellar hepatocellular carcinoma is a primary hepatic tumor that usually appears in young adults. Radical surgery is considered curative for this kind of tumor, so early diagnosis becomes essential for the prognosis of the patients. The main characteristic of this entity is the central scar, which is the center of differential diagnosis. We report the case of a 30-year-old man who was diagnosed with fibrolamellar hepatocellular carcinoma by ultrasonography. Contrast-enhanced CT confirmed this diagnosis, and the patient underwent a [18F] fluorocholine PET/CT. Hypermetabolism and the morphology in the nuclear medicine exploration suggest neoplastic nature of the lesion. Radical surgery was performed, and histopathologic analysis was performed, which resulted in focal nodular hyperplasia. Hepatic masses with central scar could have a difficult differential diagnosis, and focal nodular hyperplasia could mimic fibrolamellar hepatocellular carcinoma imaging patterns. These morphofunctional characteristics have not been described in [18F] Fluorocholine PET/CT, so there is a need to find out the potential role PET/CT in the differential diagnosis of hepatic mass with central scar.

scholarly journals Liver Multiacinar Regenerative Nodules: Imaging Findings and Clinical Implications

2018 ◽  
Vol 31 (9) ◽  
pp. 470 ◽  
Author(s):  
Henrique Donato ◽  
Luísa Andrade ◽  
Nina Bastati ◽  
Augusta Cipriano ◽  
Ahmed Ba-Ssalamah ◽  
...  
Keyword(s):  
Focal Nodular Hyperplasia ◽  
Lesion Size ◽  
Clinical Settings ◽  
Hepatobiliary Phase ◽  
Imaging Features ◽  
Imaging Findings ◽  
Vascular Abnormality ◽  
Central Scar ◽  
Nodular Hyperplasia ◽  
Regenerative Nodules

Introduction: Multiacinar regenerative nodules are benign hepatocellular nodules related to vascular disturbances of the liver. They strongly resemble conventional focal nodular hyperplasia but are connected to different clinical settings, typically chronic liver disease. The purpose of the present study was to describe the key imaging features of these lesions and compare them with a control arm of focal nodular hyperplasia.Material and Methods: A blinded consensus review of liver magnetic resonance consisting of 26 cases of multiacinar regenerative nodules and 25 cases of focal nodular hyperplasia was performed. Lesion size, shape, margins, structure, T1 and T2 signal intensity, diffusion and contrast-enhanced features (including hepatobiliary phase), presence of a central scar and of a peripheral hypointense rim were compared between the two groups.Results: Significant differences between multiacinar regenerative nodules and focal nodular hyperplasia included size (median 2.35 cm, IQR: 2.13, vs 6.00 cm, IQR: 5.20, respectively, p < 0.001), presence of a peripheral hypointense rim after contrast (n = 9 vs n = 2 cases, p = 0.038) and of a central scar (n = 9 vs n = 20, p = 0.002). There were no other significant differences.Discussion: Overall multiacinar regenerative nodules and focal nodular hyperplasia have very similar imaging features but lack of a central scar and presence of a hypointense rim should suggest a diagnosis of multiacinar regenerative nodules.Conclusions: Recognition of the imaging findings of multiacinar regenerative nodules can explain some atypical cases of focal nodular hyperplasia, avoiding unnecessary biopsies. They may also be the trigger to investigate an unsuspected underlying liver vascular abnormality.

Central Scar in Hepatic Focal Nodular Hyperplasia Revealed by Scintigraphy

2000 ◽  
Vol 25 (10) ◽  
pp. 831-832 ◽  
Author(s):  
YOJI OGAWA ◽  
ICHIRO SAKAMOTO ◽  
TOSHIO FUKUDA ◽  
AAMER AZIZ ◽  
RASHID HASHMI ◽  
...  
Keyword(s):  
Focal Nodular Hyperplasia ◽  
Central Scar ◽  
Nodular Hyperplasia

TGFβ1 and apoptosis in human hepatocellular carcinoma and focal nodular hyperplasia

1998 ◽  
Vol 28 ◽  
pp. 175 ◽  
Author(s):  
G. Lotz ◽  
P. Nagy ◽  
A. Patonai ◽  
A. Kiss ◽  
B. Nemes ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Focal Nodular Hyperplasia ◽  
Human Hepatocellular Carcinoma ◽  
Nodular Hyperplasia

scholarly journals Large Focal Nodular Hyperplasia without Central Scar : A Case of Report

2004 ◽  
Vol 29 (1) ◽  
pp. 89-93
Author(s):  
Shingo YAMASHITA ◽  
Masakazu YAMAMOTO ◽  
Kenji YOSHITOSHI ◽  
Ken TAKASAKI
Keyword(s):  
Focal Nodular Hyperplasia ◽  
Central Scar ◽  
Nodular Hyperplasia

scholarly journals A Case Report of Hepatocellular Carcinoma with be needed to Distinguish from Focal nodular hyperplasia

Kanzo ◽  
2006 ◽  
Vol 47 (9) ◽  
pp. 433-440
Author(s):  
Katsutoshi Sugimoto ◽  
Toshiya Horibe ◽  
Kosei Kudo ◽  
Ryo Metoki ◽  
Yoshihiro Furuichi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Focal Nodular Hyperplasia ◽  
Nodular Hyperplasia
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