Number of lymph node metastases and its prognostic significance in early gastric cancer: A multicenter italian study

2006 ◽  
Vol 94 (4) ◽  
pp. 275-280 ◽  
Author(s):  
Franco Roviello ◽  
Simone Rossi ◽  
Daniele Marrelli ◽  
Corrado Pedrazzani ◽  
Giovanni Corso ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Early Gastric Cancer ◽  
Lymph Node Metastases ◽  
Prognostic Significance ◽  
Italian Study ◽  
Node Metastases

Early gastric cancer with widespread lymph node metastases; A case report

1984 ◽  
Vol 14 (2) ◽  
pp. 143-145 ◽  
Author(s):  
Masashi Hirono ◽  
Shun-ichi Suehiro ◽  
Toshihiro Hirai ◽  
Minoru Niimoto ◽  
Takao Hattori
Keyword(s):  
Gastric Cancer ◽  
Case Report ◽  
Lymph Node ◽  
Early Gastric Cancer ◽  
Lymph Node Metastases ◽  
Node Metastases

The prognostic significance of Cerb-B2 determination in gastric cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e14713-e14713
Author(s):  
Antonio CALDEIRA Fradique
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Statistical Significance ◽  
Prognostic Significance ◽  
Subtotal Gastrectomy ◽  
D2 Lymphadenectomy ◽  
Tumor Aggressiveness ◽  
Resectable Gastric Cancer ◽  
Node Metastases

e14713 Background: The Cerb-B2/HER2 marker, is a glycoprotein encoded by the ERBB2 oncogene, belongs to the family of epidermal growth factor receptors (EGFR), which has based its application on tests of new therapeutic modalities (target therapy). Apart from this interest has been invoked its value as a marker of tumor aggressiveness, due to his role as a regulator of cell proliferation and migration and consequent invasiveness and metastization. However, the results as to the meaning prognosis of this molecular marker are controversial and with variations depending on the geographical zone. Results: From a total of 50 pts. with advanced resectable gastric cancer that underwent surgery with D2 lymphadenectomy, 38 pts. had a total gastrectomy, and 12 pts. had subtotal gastrectomy. A mean of 35.7 lymph nodes/pt were resected at surgery. In 68% of pts. positive lymph node metastases were present. Tumor HER2-neu overexpression was observed in 16 pts (32%), several other parameters of tumor aggressiveness were also present, without any statistical significance or relevance. Methods: To determine if the Cerb-B2 played a prognostic role in gastric cancer, a total of 50 pts. with advanced resectable gastric cancer, were submitted to gastrectomy with D2 lymphadenectomy. In all cases assessment for tumor HER2-neu overexpression was performed using immunohistochemistry (IHC). FISH was used as a confirmation method in tumors with 2+ expression by IHC. A correlation was made between the tumor HER2-neu expression and the following parameters: tumor location, size, histological type, depth of invasion, lymph node metastases and clinical staging. Results: From a total of 50 pts. with advanced resectable gastric cancer that underwent surgery with D2 lymphadenectomy, 38 pts. had a total gastrectomy, and 12 pts. had subtotal gastrectomy. A mean of 35.7 lymph nodes/pt were resected at surgery. In 68% of pts. positive lymph node metastases were present.Tumor HER2-neu overexpression was observed in 16 pts (32%), several other parameters of tumor aggressiveness were also present, without any statistical significance or relevance. Conclusions: The determination of Cerb-B2 / HER2 expression has not shown prognostic significance in this study.

Prognostic Significance of Level and Number of Lymph Node Metastases in Patients with Gastric Cancer

2007 ◽  
Vol 14 (5) ◽  
pp. 1688-1693 ◽  
Author(s):  
Hiroaki Saito ◽  
Yoji Fukumoto ◽  
Tomohiro Osaki ◽  
Kenji Fukuda ◽  
Shigeru Tatebe ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Prognostic Significance ◽  
Node Metastases

scholarly journals Numerous lymph node metastases in early gastric cancer without preoperatively enlarged lymph nodes: a case report

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Chikanori Tsutsumi ◽  
Taiki Moriyama ◽  
Kenoki Ohuchida ◽  
Koji Shindo ◽  
Shuntaro Nagai ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Report ◽  
Lymph Node ◽  
Early Gastric Cancer ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Node Metastases
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