Targeting liver tumors with hyperthermia: Ferromagnetic embolization in a rabbit liver tumor model

2001 ◽  
Vol 78 (1) ◽  
pp. 22-29 ◽  
Author(s):  
Paul Moroz ◽  
Stephen K. Jones ◽  
Jillean Winter ◽  
Bruce N. Gray
Keyword(s):  
Liver Tumor ◽  
Liver Tumors ◽  
Tumor Model ◽  
Rabbit Liver

scholarly journals Theranostic application of lipiodol for transarterial chemoembolization in a VX2 rabbit liver tumor model

Theranostics ◽  
2019 ◽  
Vol 9 (13) ◽  
pp. 3674-3686 ◽  
Author(s):  
Johanna Maria Mijntje van Breugel ◽  
Jean-François Geschwind ◽  
Sahar Mirpour ◽  
Lynn Jeanette Savic ◽  
Xuchen Zhang ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Transarterial Chemoembolization ◽  
Tumor Model ◽  
Rabbit Liver

Correlation between Hepatic Tumor Blood Flow and Glucose Utilization in a Rabbit Liver Tumor Model

Radiology ◽  
2006 ◽  
Vol 239 (3) ◽  
pp. 740-750 ◽  
Author(s):  
Errol E. Stewart ◽  
Xaiogang Chen ◽  
Jennifer Hadway ◽  
Ting-Yim Lee
Keyword(s):  
Blood Flow ◽  
Liver Tumor ◽  
Glucose Utilization ◽  
Tumor Model ◽  
Hepatic Tumor ◽  
Rabbit Liver ◽  
Tumor Blood Flow

Percutaneous liquid ablation agent for tumor treatment and drug delivery

2021 ◽  
Vol 13 (580) ◽  
pp. eabe3889
Author(s):  
Hassan Albadawi ◽  
Zefu Zhang ◽  
Izzet Altun ◽  
Jingjie Hu ◽  
Leila Jamal ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Ionic Liquid ◽  
Liver Tumor ◽  
Thermal Ablation ◽  
Liver Tumors ◽  
Low Cost ◽  
Drug Distribution ◽  
Tumor Model ◽  
Ablation Zone ◽  
Synergistic Cytotoxicity

Percutaneous locoregional therapies (LRTs), such as thermal ablation, are performed to limit the progression of hepatocellular carcinoma (HCC) and offer a bridge for patients waiting for liver transplantation. However, physiological challenges related to tumor location, size, and existence of multiple lesions as well as safety concerns related to potential thermal injury to adjacent tissues may preclude the use of thermal ablation or lead to its failure. Here, we showed a successful injection of an ionic liquid into tissue under image guidance, ablation of tumors in response to the injected ionic liquid, and persistence (28 days) of coinjected chemotherapy with the ionic liquid in the ablation zone. In a rat HCC model, the rabbit VX2 liver tumor model, and 12 human resected tumors, injection of the ionic liquid led to consistent tumor ablation. Combining the ionic liquid with the chemotherapy agent, doxorubicin, resulted in synergistic cytotoxicity when tested with cultured HCC cells and uniform drug distribution throughout the ablation zone when percutaneously injected into liver tumors in the rabbit liver tumor model. Because this ionic liquid preparation is simple to use, is efficacious, and has a low cost, we propose that this new LRT may bridge more patients to liver transplantation.

Intraarterial Therapy Using Micellar Nanoparticles Incorporating SN-38 in a Rabbit Liver Tumor Model

2017 ◽  
Vol 28 (3) ◽  
pp. 457-464 ◽  
Author(s):  
Hideyuki Nishiofuku ◽  
Toshihiro Tanaka ◽  
Yasushi Fukuoka ◽  
Takeshi Sato ◽  
Tetsuya Masada ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Tumor Model ◽  
Rabbit Liver ◽  
Intraarterial Therapy ◽  
Micellar Nanoparticles

scholarly journals Automated Quantification of Tumor Viability in a Rabbit Liver Tumor Model after Chemoembolization Using Infrared Imaging

2015 ◽  
Vol 185 (7) ◽  
pp. 1877-1888 ◽  
Author(s):  
Hadrien D'inca ◽  
Julien Namur ◽  
Saida Homayra Ghegediban ◽  
Michel Wassef ◽  
Florentina Pascale ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Infrared Imaging ◽  
Tumor Model ◽  
Rabbit Liver ◽  
Automated Quantification ◽  
Tumor Viability

scholarly journals Mapping of drug distribution in the rabbit liver tumor model by complementary fluorescence and mass spectrometry imaging

2018 ◽  
Vol 269 ◽  
pp. 128-135 ◽  
Author(s):  
Katrin Fuchs ◽  
Andras Kiss ◽  
Pierre E. Bize ◽  
Rafael Duran ◽  
Alban Denys ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liver Tumor ◽  
Mass Spectrometry Imaging ◽  
Drug Distribution ◽  
Tumor Model ◽  
Rabbit Liver

scholarly journals PL-019 Effect of early exercise on autophagy of liver tumor in mice

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Ning Jiang ◽  
Zhe Wang ◽  
Jing Li ◽  
Xinghao Wang
Keyword(s):  
Exercise Training ◽  
Liver Tumor ◽  
Liver Tumors ◽  
Hepatoma Cell ◽  
Tumor Model ◽  
Inflammatory Cells ◽  
Exercise Group ◽  
Control Group ◽  
Early Exercise ◽  
Tumor Group

Objective To investigate whether the liver autophagy level can be altered by pre exercise training in mice liver tumors. Methods 40 Male C57BL/6J mice aged 7 months were randomly divided into 2 groups: control group (YC) and exercise group (YE). YE were exercised on a treadmill for 12 weeks (12m/min). After12 weeks each group was randomly divided into two groups. The tumor model was constructed by injection of HEPA1- 6 mouse hepatoma cell into liver tissue.Then the groups were control group (YC), exercise group (YE), tumor group (YCT), exercise tumor group (YET).The experimental samples were prepared on the 13 day after the tumor model was constructed. the hematoxylin and eosin stain of the liver was observed.The expression of autophagy related protein BECLIN1, LC3-II and ATG5 in liver tissues of mice was detected by Western blot. Results Compared with YCT group,the boundary of inflammatory cells and tumor cells in YET group was clear with normal cells.Compared with YCT group, the expression levels of BECLIN1, LC3-II and ATG5 in liver tissue of YET group were significantly higher (p < 0.01, P < 0.01, P < 0.05). Conclusions Early exercise can help the 7 month old mice to resist the occurrence and development of the liver tumor. It's probably associated with increased level of autophagy in the liver by early exercise training.

scholarly journals Selective hypoxia-activated intraarterial therapy in a rabbit liver tumor model

2015 ◽  
Vol 26 (2) ◽  
pp. S7-S8
Author(s):  
R. Duran ◽  
S. Mirpour ◽  
V. Pekurovsky ◽  
S. Ganapathy-Kanniappan ◽  
C.F. Brayton ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Tumor Model ◽  
Rabbit Liver ◽  
Intraarterial Therapy
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