Malignant melanoma developing in an area of hereditary palmoplantar keratoderma (Mal De Meleda)

2003 ◽  
Vol 84 (4) ◽  
pp. 229-233 ◽  
Author(s):  
Nicola Mozzillo ◽  
Carmine A. Nunziata ◽  
Corrado Caracò ◽  
Flavio Fazioli ◽  
Gerardo Botti
Keyword(s):  
Malignant Melanoma ◽  
Palmoplantar Keratoderma ◽  
Mal De Meleda

Acral Malignant Melanoma and Striated Palmoplantar Keratoderma (Brunauer-Fohs-Siemens Syndrome)

2004 ◽  
Vol 30 (12, PART 2) ◽  
pp. 1539-1542
Author(s):  
PIETRO RUBEGNI ◽  
SARA POGGIALI ◽  
ALDO CUCCIA ◽  
MAURIZIO BIAGIOLI ◽  
MICHELE FIMIANI
Keyword(s):  
Malignant Melanoma ◽  
Palmoplantar Keratoderma

Malignant melanoma in a patient with mal de Meleda

2016 ◽  
Vol 41 (4) ◽  
pp. 437-439 ◽  
Author(s):  
A. Vilas-Sueiro ◽  
E. Rosón ◽  
J.-M. Suárez-Peñaranda ◽  
I. Vázquez-Osorio ◽  
D. Sánchez-Aguilar ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Mal De Meleda

Malignant melanoma in association with palmoplantar keratoderma

1999 ◽  
Vol 22 (1) ◽  
pp. 49-50 ◽  
Author(s):  
A. C. Aygit ◽  
H. N. Bayçin ◽  
A. Demiralay
Keyword(s):  
Malignant Melanoma ◽  
Palmoplantar Keratoderma

Malignant Melanoma Developing in an Area of Palmoplantar Keratoderma (Greither's Disease)

1995 ◽  
Vol 22 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Takuya Seike ◽  
Hideki Nakanishi ◽  
Yoshio Urano ◽  
Seiji Arase
Keyword(s):  
Malignant Melanoma ◽  
Palmoplantar Keratoderma

Acral Malignant Melanoma and Striated Palmoplantar Keratoderma (Brunauer-Fohs-Siemens Syndrome): A Fortuitous Association?

2004 ◽  
Vol 30 (12p2) ◽  
pp. 1539-1542 ◽  
Author(s):  
Pietro Rubegni ◽  
Sara Poggiali ◽  
Aldo Cuccia ◽  
Maurizio Biagioli ◽  
Michele Fimiani
Keyword(s):  
Malignant Melanoma ◽  
Palmoplantar Keratoderma

Mal de Meleda-like Palmoplantar Keratoderma

1991 ◽  
Vol 18 (1) ◽  
pp. 43-46 ◽  
Author(s):  
Tomoe Iio ◽  
Satoshi Shiraishi ◽  
Koji Sayama ◽  
Yoshiharu Miki
Keyword(s):  
Palmoplantar Keratoderma ◽  
Mal De Meleda

scholarly journals Particular Mal de Meleda Phenotypes in Tunisia and Mutations Founder Effect in the Mediterranean Region

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Mbarka Bchetnia ◽  
Nadia Laroussi ◽  
Monia Youssef ◽  
Cherine Charfeddine ◽  
Ahlem Sabrine Ben Brick ◽  
...  
Keyword(s):  
Founder Effect ◽  
Mutational Analysis ◽  
Phenotypic Variability ◽  
Genetic Defect ◽  
Molecular Defect ◽  
Mediterranean Population ◽  
Palmoplantar Keratoderma ◽  
The Mediterranean ◽  
Hands And Feet ◽  
Mal De Meleda

Mal de Meleda (MDM) is a rare, autosomal recessive form of palmoplantar keratoderma. It is characterized by erythema and hyperkeratosis of the palms and soles that progressively extend to the dorsal surface of the hands and feet. It is caused by mutations inSLURP-1gene encoding for secreted mammalian Ly-6/uPAR-related protein 1 (SLURP-1). We performed mutational analysis by direct sequencing ofSLURP-1gene in order to identify the genetic defect in three unrelated families (families MDM-12, MDM-13, and MDM-14) variably affected with transgressive palmoplantar keratoderma. A spectrum of clinical presentations with variable features has been observed from the pronounced to the transparent hyperkeratosis. We identified the 82delT frame shift mutation in theSLURP-1gene in both families MDM-12 and MDM-13 and the missense variation p.Cys99Tyr in family MDM-14. To date, the 82delT variation is the most frequent cause of MDM in the world which is in favour of a recurrent molecular defect. The p.Cys99Tyr variation is only described in Tunisian families making evidence of founder effect mutation of likely Tunisian origin. Our patients presented with very severe to relatively mild phenotypes, including multiple keratolytic pits observed for one patient in the hyperkeratotic area which was not previously reported. The phenotypic variability may reflect the influence of additional factors on disease characteristics. This report further expands the spectrum of clinical phenotypes associated with mutations inSLURP1in the Mediterranean population.

scholarly journals Palmoplantar Keratoderma of the Gamborg-Nielsen Type is Caused by Mutations in the SLURP1 Gene and Represents a Variant of Mal de Meleda

2014 ◽  
Vol 94 (6) ◽  
pp. 707-710 ◽  
Author(s):  
L Zhao ◽  
A Vahlquist ◽  
M Virtanen ◽  
L Wennerstrand ◽  
L Lind ◽  
...  
Keyword(s):  
Palmoplantar Keratoderma ◽  
Mal De Meleda

A Case of Malignant Melanoma Arising from Palmoplantar Keratoderma

2008 ◽  
Vol 70 (6) ◽  
pp. 625-629
Author(s):  
Hajime TOMITA ◽  
Youhei IWATA ◽  
Humihide OGAWA ◽  
Shinichi SATO ◽  
Yuuichirou AKIYAMA ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Palmoplantar Keratoderma

Olmsted Syndrome—Palmoplantar and Periorificial Keratodermas: Association with Malignant Melanoma

2003 ◽  
Vol 7 (3) ◽  
pp. 236-242 ◽  
Author(s):  
Josee Dessureault ◽  
Yves Poulin ◽  
Marc Bourcier ◽  
Eric Gagne
Keyword(s):  
Malignant Melanoma ◽  
Squamous Cell ◽  
Congenital Disorder ◽  
Rare Disorder ◽  
Palmoplantar Keratoderma ◽  
Epithelial Tumors ◽  
Rare Congenital Disorder ◽  
Promising Treatment

Background: Olmsted syndrome is a rare congenital disorder with mutilating palmoplantar keratoderma, periorificial keratotic plaques, and other variable features. Objective: We describe a 65-year-old woman with Olmsted syndrome complicated by the occurrence of a malignant melanoma inside the plantar keratoderma. To our knowledge, this is the first reported case of such an occurrence in Olmsted syndrome. The published cases of this rare disorder are reviewed. Conclusion: An association between malignant epithelial tumors and Olmsted syndrome has already been reported. The association of malignant melanoma with other types of palmoplantar keratodermas has been reported. This may suggest a predisposition to melanocytic as well as squamous cell malignancies in congenital keratodermas. Oral retinoids appear to be the most promising treatment for Olmsted syndrome and for other symptomatic keratodermas.

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