The role of preoperative ultrasound scan in detecting lymph node metastasis before sentinel node biopsy in melanoma patients

2003 ◽  
Vol 83 (2) ◽  
pp. 80-84 ◽  
Author(s):  
Carlo Riccardo Rossi ◽  
Simone Mocellin ◽  
Barbara Scagnet ◽  
Mirto Foletto ◽  
Antonella Vecchiato ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Ultrasound Scan ◽  
Node Metastasis ◽  
Node Biopsy ◽  
Preoperative Ultrasound ◽  
Melanoma Patients

scholarly journals A case of prevascular lymph node metastasis from the carcinoma of tongue diagnosed using the method of sentinel node biopsy

2003 ◽  
Vol 13 (3) ◽  
pp. 147-152
Author(s):  
Takashi Matsuzuka ◽  
Makoto Kano ◽  
Masahiro Suzuki ◽  
Yukio Nomoto ◽  
Teruhisa Suzuki ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Node Metastasis ◽  
Node Biopsy ◽  
Carcinoma Of Tongue

scholarly journals Significance of Lymph Node Metastasis in the Treatment of Gastric Cancer and Current Challenges in Determining the Extent of Metastasis

2022 ◽  
Vol 11 ◽  
Author(s):  
Shinichi Kinami ◽  
Hitoshi Saito ◽  
Hiroyuki Takamura
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Lymph Nodes ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Lymph Node Dissection ◽  
Node Dissection ◽  
Node Metastasis ◽  
Node Biopsy

The stomach exhibits abundant lymphatic flow, and metastasis to lymph nodes is common. In the case of gastric cancer, there is a regularity to the spread of lymph node metastasis, and it does not easily metastasize outside the regional nodes. Furthermore, when its extent is limited, nodal metastasis of gastric cancer can be cured by appropriate lymph node dissection. Therefore, identifying and determining the extent of lymph node metastasis is important for ensuring accurate diagnosis and appropriate surgical treatment in patients with gastric cancer. However, precise detection of lymph node metastasis remains difficult. Most nodal metastases in gastric cancer are microscopic metastases, which often occur in small-sized lymph nodes, and are thus difficult to diagnose both preoperatively and intraoperatively. Preoperative nodal diagnoses are mainly made using computed tomography, although the specificity of this method is low because it is mainly based on the size of the lymph node. Furthermore, peripheral nodal metastases cannot be palpated intraoperatively, nodal harvesting of resected specimens remains difficult, and the number of lymph nodes detected vary greatly depending on the skill of the technician. Based on these findings, gastrectomy with prophylactic lymph node dissection is considered the standard surgical procedure for gastric cancer. In contrast, several groups have examined the value of sentinel node biopsy for accurately evaluating nodal metastasis in patients with early gastric cancer, reporting high sensitivity and accuracy. Sentinel node biopsy is also important for individualizing and optimizing the extent of uniform prophylactic lymph node dissection and determining whether patients are indicated for function-preserving curative gastrectomy, which is superior in preventing post-gastrectomy symptoms and maintaining dietary habits. Notably, advancements in surgical treatment for early gastric cancer are expected to result in individualized surgical strategies with sentinel node biopsy. Chemotherapy for advanced gastric cancer has also progressed, and conversion gastrectomy can now be performed after downstaging, even in cases previously regarded as inoperable. In this review, we discuss the importance of determining lymph node metastasis in the treatment of gastric cancer, the associated difficulties, and the need to investigate strategies that can improve the diagnosis of lymph node metastasis.

scholarly journals Correlation of coagulation markers with axillary lymph node metastasis in breast malignancy: a tertiary care centre study in North India

2020 ◽  
Vol 7 (4) ◽  
pp. 1045
Author(s):  
Vaibhav Srivastava ◽  
Nandan Rai ◽  
Shabi Ahmad ◽  
Vikram Singh ◽  
Shirish Kumar
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Factor Viii ◽  
Sentinel Node ◽  
Factor Vii ◽  
Carcinoma Breast ◽  
Node Metastasis ◽  
Node Biopsy ◽  
D Dimer

Background: Breast cancer is the most common female cancer worldwide representing nearly a quarter (25%) of all cancers. Search for a marker which can predict lymph node metastasis in clinically negative axilla has been a matter of research for long. The present study is an attempt to evaluate role of coagulation makers with special reference to D-dimer and factor 7 and 8 in patients of carcinoma breast in predicting lymph node metastasis in carcinoma patients.Methods: The study was a prospective study conducted in 50 diagnosed patients of carcinoma breast in whom D dimer levels and factor 7 and 8 levels were measured at the time of commencement of the treatment and at six weeks after surgery.Results: Most of the patients in the study group were in the age group 41-70 (80%) years. 22% patients were of early Breast cancer. The reduction in D-dimer, factor VII and factor VIII value after 6 weeks of surgery were significant (p value 0.0001 for all three).Conclusions: D-dimer and factor VII were found to be an independent predictive factor for lymph node metastatsis, thus providing as a safe, easy, objective and convenient supplement to sentinel node biopsy in assessing metastatic disease in axilla. Combined- with other biomarkers, it may prove to be an alternative to sentinel node biopsy in assessing metastatic disease in axilla. Significant postoperative decrease in D-dimer, factor VII and factor VIII may provide objective criteria to assess completion of surgery.

Routine PET and PET-CT scans in melanoma patients with positive sentinel node biopsy is of limited benefit

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 8582-8582
Author(s):  
A. Constantinidou ◽  
M. Hofman ◽  
M. O'Doherty ◽  
K. Acland ◽  
C. Healy ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Pet Scan ◽  
Positive Sentinel Node ◽  
Node Biopsy ◽  
Pet Scanning ◽  
Pet Scans

8582 Background: Positron emission tomography (PET) scanning is increasingly used for the staging and management of malignant melanoma. The role of PET as a routine procedure in patients with positive sentinel node biopsy (SNB) is not yet established. We report in the series with longest follow up outcomes of PET scans performed in patients with subclinical lymph node disease. Methods: Case notes of 29 sequential patients with melanoma of Breslow thickness greater than 1mm who had PET scans within 130 days after a positive SNB were reviewed. Four patients had a PET after the lymph node dissection (LND). Results: 2 patients (6%) had a positive PET scan neither of which was melanoma related. The first patient had a thyroid tumour confirmed with fine needle aspiration biopsy and the second patient had increased uptake in the chest wall which on verification with bone scan proved to be old trauma. 28 patients (96%) had a LND and this was positive in 5 cases (17%). With a median follow up of 23 months 21 patients remained disease free. Out of the 8 patients (27%) who presented with recurrence 2 (25%) were successfully treated with further surgery and remained in remission, 4 (50%) died, 1 (12.5%) was lost from follow-up and 1 (12.5%) is followed up in another hospital. In none of the 29 cases did the early PET scan after a positive SNB alter subsequent melanoma management. Conclusions: The role of PET scanning soon after a positive sentinel node biopsy appears to be of uncertain benefit. It is questionable whether any imaging is beneficial at this stage. The results of this review suggest that PET scanning might not be indicated for this group of patients but larger prospective studies are required to confirm this. Patients Characteristics No % Male 15 (51) Female 14 (49) Melanoma Type: Nodular 8 (27) Superficial spreading 15 (51) Other 2 (6) Unknown 4 (13) Breslow thickness: 1.0–1.9 13 (44) 2.00–3.9 14 (49) ○= 4.0 2 (6) Ulceration: Yes 3 (10) No 25 (86) Unknown 1 (3) Age Median 56 No significant financial relationships to disclose.

Prognostic importance of lymph node tumor burden in melanoma patients staged by sentinel node biopsy

2002 ◽  
Vol 9 (10) ◽  
pp. 975-981 ◽  
Author(s):  
Jaime M. Ranieri ◽  
Jeffrey D. Wagner ◽  
Rafael Azuaje ◽  
D. Davidson ◽  
Stacie Wenck ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Node ◽  
Sentinel Node Biopsy ◽  
Tumor Burden ◽  
Node Biopsy ◽  
Prognostic Importance ◽  
Melanoma Patients
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