Prognostic impact of DNA ploidy pattern, S-phase fraction (SPF), and proliferating cell nuclear antigen (PCNA) in patients with primary gastric lymphoma

2003 ◽  
Vol 82 (4) ◽  
pp. 247-255 ◽  
Author(s):  
Chrysoula J. Belessi ◽  
Aikaterini S. Parasi ◽  
Helen S. Manioudaki ◽  
Nikolaos P. Laoutaris ◽  
Nikolaos C. Legakis ◽  
...  
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Dna Ploidy ◽  
Gastric Lymphoma ◽  
S Phase ◽  
Nuclear Antigen ◽  
Prognostic Impact ◽  
Dna Ploidy Pattern ◽  
Primary Gastric Lymphoma ◽  
Ploidy Pattern ◽  
Proliferating Cell

scholarly journals DNA ploidy pattern and proliferating cell nuclear antigen(PCNA) labeling index in small hepatocellular carcinoma.

Kanzo ◽  
1994 ◽  
Vol 35 (8) ◽  
pp. 596-600 ◽  
Author(s):  
Mikiya KITAMOTO ◽  
Toshio NAKANISHI ◽  
Shinsuke KIRA ◽  
Ryo NAKASHIO ◽  
Minoru KAWAGUCHI ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Proliferating Cell Nuclear Antigen ◽  
Dna Ploidy ◽  
Labeling Index ◽  
Nuclear Antigen ◽  
Small Hepatocellular Carcinoma ◽  
Dna Ploidy Pattern ◽  
Ploidy Pattern ◽  
Proliferating Cell

The expression of proliferating cell nuclear antigen, p53, p21, and apoptosis in primary gastric lymphoma

Surgery ◽  
2002 ◽  
Vol 132 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Keishiro Aoyagi ◽  
Kikuo Kohfuji ◽  
Shojiro Yano ◽  
Naotaka Murakami ◽  
Motoshi Miyagi ◽  
...  
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Gastric Lymphoma ◽  
Nuclear Antigen ◽  
Primary Gastric Lymphoma ◽  
Proliferating Cell

scholarly journals Effect of Proliferating Cell Nuclear Antigen Ubiquitination and Chromatin Structure on the Dynamic Properties of the Y-family DNA Polymerases

2008 ◽  
Vol 19 (12) ◽  
pp. 5193-5202 ◽  
Author(s):  
Simone Sabbioneda ◽  
Audrey M. Gourdin ◽  
Catherine M. Green ◽  
Angelika Zotter ◽  
Giuseppina Giglia-Mari ◽  
...  
Keyword(s):  
Chromatin Structure ◽  
Proliferating Cell Nuclear Antigen ◽  
Dynamic Properties ◽  
Human Fibroblasts ◽  
Dna Polymerases ◽  
S Phase ◽  
Nuclear Antigen ◽  
Replication Foci ◽  
Y Family ◽  
Proliferating Cell

Y-family DNA polymerases carry out translesion synthesis past damaged DNA. DNA polymerases (pol) η and ι are usually uniformly distributed through the nucleus but accumulate in replication foci during S phase. DNA-damaging treatments result in an increase in S phase cells containing polymerase foci. Using photobleaching techniques, we show that polη is highly mobile in human fibroblasts. Even when localized in replication foci, it is only transiently immobilized. Although ubiquitination of proliferating cell nuclear antigen (PCNA) is not required for the localization of polη in foci, it results in an increased residence time in foci. polι is even more mobile than polη, both when uniformly distributed and when localized in foci. Kinetic modeling suggests that both polη and polι diffuse through the cell but that they are transiently immobilized for ∼150 ms, with a larger proportion of polη than polι immobilized at any time. Treatment of cells with DRAQ5, which results in temporary opening of the chromatin structure, causes a dramatic immobilization of polη but not polι. Our data are consistent with a model in which the polymerases are transiently probing the DNA/chromatin. When DNA is exposed at replication forks, the polymerase residence times increase, and this is further facilitated by the ubiquitination of PCNA.

DNA ploidy pattern and S-phase characteristics of metastatic melanoma

1991 ◽  
Vol 60 (1) ◽  
pp. 253-257 ◽  
Author(s):  
T. Muhonen ◽  
S. Pyrhönen ◽  
A. Laasonen ◽  
S. Asko-Seljavaara ◽  
K. Franssila
Keyword(s):  
Metastatic Melanoma ◽  
Dna Ploidy ◽  
S Phase ◽  
Dna Ploidy Pattern ◽  
Ploidy Pattern

DNA Ploidy and Proliferating Cell Nuclear Antigen Image Analysis of Peritoneal and Pleural Effusions

1997 ◽  
Vol 41 (3) ◽  
pp. 636-648 ◽  
Author(s):  
Ahmed H. EL-Habashi ◽  
Scott M. Freeman ◽  
Bahiga EL-Morsi ◽  
Munir EL-Didi ◽  
Andrew Martin ◽  
...  
Keyword(s):  
Image Analysis ◽  
Proliferating Cell Nuclear Antigen ◽  
Dna Ploidy ◽  
Nuclear Antigen ◽  
Pleural Effusions ◽  
Proliferating Cell
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