A metagenomic analysis of the modulatory effect of Cyclocarya paliurus flavonoids on the intestinal microbiome in a high‐fat diet‐induced obesity mouse model

2019 ◽  
Vol 99 (8) ◽  
pp. 3967-3975 ◽  
Author(s):  
Lu Cheng ◽  
Yuhui Chen ◽  
Xin Zhang ◽  
Xiaojie Zheng ◽  
Jinxuan Cao ◽  
...  
Keyword(s):  
Mouse Model ◽  
High Fat Diet ◽  
Intestinal Microbiome ◽  
Metagenomic Analysis ◽  
High Fat ◽  
Cyclocarya Paliurus ◽  
Diet Induced Obesity

Metagenomics approach to the intestinal microbiome structure and function in high fat diet-induced obesity in mice fed with conjugated linoleic acid (CLA)

2020 ◽  
Vol 11 (11) ◽  
pp. 9729-9739
Author(s):  
Lina Liu ◽  
Yingying He ◽  
Kai Wang ◽  
Jinlai Miao ◽  
Zhou Zheng
Keyword(s):  
Linoleic Acid ◽  
Mouse Model ◽  
Conjugated Linoleic Acid ◽  
High Fat Diet ◽  
Structure And Function ◽  
Intestinal Microbiome ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice ◽  
And Function

In this study, a high fat diet induced obesity mouse model (DIO) was used to investigate the modulatory effect of high purity conjugated linoleic acid (CLA) on the intestinal microbiota.

scholarly journals Antiobesity Effects ofBifidobacterium breveStrain B-3 Supplementation in a Mouse Model with High-Fat Diet-Induced Obesity

2010 ◽  
Vol 74 (8) ◽  
pp. 1656-1661 ◽  
Author(s):  
Shizuki KONDO ◽  
Jin-zhong XIAO ◽  
Takumi SATOH ◽  
Toshitaka ODAMAKI ◽  
Sachiko TAKAHASHI ◽  
...  
Keyword(s):  
Mouse Model ◽  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity

scholarly journals Minor role of mature adipocyte mineralocorticoid receptor in high-fat diet-induced obesity

2018 ◽  
Vol 239 (2) ◽  
pp. 229-240 ◽  
Author(s):  
A Feraco ◽  
A Armani ◽  
R Urbanet ◽  
A Nguyen Dinh Cat ◽  
V Marzolla ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Mouse Model ◽  
High Fat Diet ◽  
Mineralocorticoid Receptor ◽  
Metabolic Effects ◽  
Minor Role ◽  
High Fat ◽  
Mature Adipocyte ◽  
Diet Induced Obesity ◽  
Significant Difference

Obesity is a major risk factor that contributes to the development of cardiovascular disease and type 2 diabetes. Mineralocorticoid receptor (MR) expression is increased in the adipose tissue of obese patients and several studies provide evidence that MR pharmacological antagonism improves glucose metabolism in genetic and diet-induced mouse models of obesity. In order to investigate whether the lack of adipocyte MR is sufficient to explain these beneficial metabolic effects, we generated a mouse model with inducible adipocyte-specific deletion of Nr3c2 gene encoding MR (adipo-MRKO). We observed a significant, yet not complete, reduction of Nr3c2 transcript and MR protein expression in subcutaneous and visceral adipose depots of adipo-MRKO mice. Notably, only mature adipocyte fraction lacks MR, whereas the stromal vascular fraction maintains normal MR expression in our mouse model. Adipo-MRKO mice fed a 45% high-fat diet for 14 weeks did not show any significant difference in body weight and fat mass compared to control littermates. Glucose and insulin tolerance tests revealed that mature adipocyte MR deficiency did not improve insulin sensitivity in response to a metabolic homeostatic challenge. Accordingly, no significant changes were observed in gene expression profile of adipogenic and inflammatory markers in adipose tissue of adipo-MRKO mice. Moreover, pharmacological MR antagonism in mature primary murine adipocytes, which differentiated ex vivo from WT mice, did not display any effect on adipokine expression. Taken together, these data demonstrate that the depletion of MR in mature adipocytes displays a minor role in diet-induced obesity and metabolic dysfunctions.

A metagenomics approach to the intestinal microbiome structure and function in high fat diet-induced obesity mice fed with oolong tea polyphenols

2018 ◽  
Vol 9 (2) ◽  
pp. 1079-1087 ◽  
Author(s):  
Mei Cheng ◽  
Xin Zhang ◽  
Jieyu Zhu ◽  
Lu Cheng ◽  
Jinxuan Cao ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Structure And Function ◽  
Tea Polyphenols ◽  
Intestinal Microbiome ◽  
Obese Mice ◽  
High Fat ◽  
Oolong Tea ◽  
Diet Induced Obesity ◽  
And Function ◽  
Human Flora

We investigate the modulatory effect of oolong tea polyphenols on the intestinal microbiota in human flora-associated high fat diet induced obese mice.

Hepatic gene expression profiles in a long-term high-fat diet-induced obesity mouse model

Gene ◽  
2004 ◽  
Vol 340 (1) ◽  
pp. 99-109 ◽  
Author(s):  
Sujong Kim ◽  
Insuk Sohn ◽  
Joon-Ik Ahn ◽  
Ki-Hwan Lee ◽  
Yeon Sook Lee ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Model ◽  
High Fat Diet ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Hepatic Gene Expression ◽  
High Fat ◽  
Diet Induced Obesity
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