Activity-guided isolation of phase II enzyme inducers from buckwheat flour methanolic extracts

2018 ◽  
Vol 98 (13) ◽  
pp. 4911-4918
Author(s):  
Rong-ying Qiu ◽  
Jun-ru Wang ◽  
Kirk L Parkin
Keyword(s):  
Phase Ii ◽  
Methanolic Extracts ◽  
Phase Ii Enzyme ◽  
Buckwheat Flour ◽  
Enzyme Inducers

New hybrid bromopyridine-chalcones as in vivo phase II enzyme inducers: potential chemopreventive agents

MedChemComm ◽  
2016 ◽  
Vol 7 (12) ◽  
pp. 2395-2409 ◽  
Author(s):  
Mauricio Cabrera ◽  
Hugo Cerecetto ◽  
Mercedes González
Keyword(s):  
Phase Ii ◽  
Chemopreventive Agents ◽  
Phase Ii Enzyme ◽  
Potential Cancer ◽  
Enzyme Inducers

We report the synthesis of eighteen new potential cancer chemopreventive agents, structurally designed to combine (naphtho)chalcone and (bromo)pyridine skeletons.

scholarly journals Polybacterial Periodontal Pathogens Alter Vascular and Gut BH4/nNOS/NRF2-Phase II Enzyme Expression

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0129885 ◽  
Author(s):  
Pandu Gangula ◽  
Kalpana Ravella ◽  
Sasanka Chukkapalli ◽  
Mercedes Rivera ◽  
Shanthi Srinivasan ◽  
...  
Keyword(s):  
Phase Ii ◽  
Periodontal Pathogens ◽  
Enzyme Expression ◽  
Phase Ii Enzyme

scholarly journals Protective Effects of Aqueous Extract of Mentha suaveolens against Oxidative Stress-Induced Damages in Human Keratinocyte HaCaT Cells

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
HansongI Lee ◽  
Miji Yeom ◽  
Seoungwoo Shin ◽  
Kyungeun Jeon ◽  
Deokhoon Park ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Phase Ii ◽  
Aqueous Extract ◽  
Biological Activities ◽  
Ros Generation ◽  
Related Factor ◽  
Hacat Cells ◽  
Human Keratinocyte ◽  
Wide Range ◽  
Phase Ii Enzyme

Mentha suaveolens is an aromatic herb that has a wide range of biological activities, including antimicrobial, antifungal, anti-inflammatory, and hepatoprotective properties. Although there are a few reports on the antioxidant property of M. suaveolens, its cytoprotective activity against oxidative stress has not been reported yet. The objective of this study was to determine the protective activity of M. suaveolens aqueous extract (MSAE) against hydrogen peroxide- (H2O2-) induced oxidative stress and apoptosis in human keratinocyte HaCaT cells. MSAE pretreatment decreased H2O2-induced cytotoxicity and suppressed H2O2-induced intracellular ROS generation. Furthermore, MSAE suppressed expression levels of H2O2-induced apoptotic genes such as cleaved caspase-3, caspase-9, and cleaved poly (ADP-ribose) polymerase (PARP). Pretreatment with MSAE induced expression of phase II enzyme such as HO-1 through translocation of NF-E2-related factor (Nrf2) upon H2O2 exposure. These results revealed that the cytoprotective effect of MSAE against oxidative stress-induced cell death was associated with activation of Nrf2-mediated phase II enzyme expression.

scholarly journals Relationship between GST Yp Induction and Hepatocyte Proliferation in Rats Treated with Phase II Drug Metabolizing Enzyme Inducers

2008 ◽  
Vol 36 (3) ◽  
pp. 420-427 ◽  
Author(s):  
Toshihiko Makino ◽  
Kayoko Ishikawa ◽  
Isao Igarashi ◽  
Takashi Yamoto ◽  
Sunao Manabe ◽  
...  
Keyword(s):  
Phase Ii ◽  
Hepatocyte Proliferation ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme ◽  
Enzyme Inducers

Comparative antioxidant, antiproliferative and phase II enzyme inducing potential of sorghum (Sorghum bicolor) varieties

LWT ◽  
2009 ◽  
Vol 42 (6) ◽  
pp. 1041-1046 ◽  
Author(s):  
Joseph M. Awika ◽  
Liyi Yang ◽  
Jimmy D. Browning ◽  
Abdul Faraj
Keyword(s):  
Sorghum Bicolor ◽  
Phase Ii ◽  
Phase Ii Enzyme
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