Saponins extracted from by-product of Asparagus officinalis L. suppress tumour cell migration and invasion through targeting Rho GTPase signalling pathway

2013 ◽  
Vol 93 (6) ◽  
pp. 1492-1498 ◽  
Author(s):  
Jieqiong Wang ◽  
Yali Liu ◽  
Jingjing Zhao ◽  
Wen Zhang ◽  
Xiufeng Pang
Keyword(s):  
Cell Migration ◽  
Tumour Cell ◽  
Rho Gtpase ◽  
Signalling Pathway ◽  
Asparagus Officinalis ◽  
Migration And Invasion ◽  
Cell Migration And Invasion

scholarly journals Ion channels and transporters in tumour cell migration and invasion

2014 ◽  
Vol 369 (1638) ◽  
pp. 20130102 ◽  
Author(s):  
Albrecht Schwab ◽  
Christian Stock
Keyword(s):  
Cell Migration ◽  
Ion Channels ◽  
Ion Transport ◽  
Tumour Cell ◽  
Transport Proteins ◽  
Migration And Invasion ◽  
Central Component ◽  
Cell Migration And Invasion ◽  
Candidate Target ◽  
Cytoskeletal Elements

Cell migration is a central component of the metastatic cascade requiring a concerted action of ion channels and transporters (migration-associated transportome), cytoskeletal elements and signalling cascades. Ion transport proteins and aquaporins contribute to tumour cell migration and invasion among other things by inducing local volume changes and/or by modulating Ca 2+ and H + signalling. Targeting cell migration therapeutically bears great clinical potential, because it is a prerequisite for metastasis. Ion transport proteins appear to be attractive candidate target proteins for this purpose because they are easily accessible as membrane proteins and often overexpressed or activated in cancer. Importantly, a number of clinically widely used drugs are available whose anticipated efficacy as anti-tumour drugs, however, has now only begun to be evaluated.

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