A comparative study on viscosity behavior of water-soluble chemically modified guar gum derivatives with different functional lateral groups

2005 ◽  
Vol 85 (15) ◽  
pp. 2638-2644 ◽  
Author(s):  
Li-Ming Zhang ◽  
Jian-Fang Zhou ◽  
Peter S Hui
Keyword(s):  
Comparative Study ◽  
Guar Gum ◽  
Water Soluble ◽  
Chemically Modified ◽  
Viscosity Behavior

A Comparative Study of Matrix Tablets Designed by Different Methods

2017 ◽  
Vol 10 (2) ◽  
pp. 3645-3652
Author(s):  
Tulsi Bisht ◽  
Rishishwar Poonam
Keyword(s):  
Drug Release ◽  
Comparative Study ◽  
Guar Gum ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Matrix Tablet ◽  
Once Daily ◽  
Gum Acacia ◽  
Weight Variation ◽  
Evaluation Parameters

The aim of present work was to develop once daily sustained release matrix tablet of aceclofenac by wet granulation technique using natural gums i.e.: gum acacia, guar gum and Xanthan gum. In this present study matrix tablets were prepared using three different methods and a comparative study was done. Aceclofenac sodium being the newer derivative of diclofenac having short biological half life (4hrs.), so it requires more than one dose per day to maintain therapeutic dose. The prepared tablets were evaluated for various parameters like weight variation, hardness, swelling index, friability, percent drug release and various release profile like zero order, first order, Higuchi's, and Koshemeyrs-peppa. All the evaluation parameters met pharmacopoeial specifications and through dissolution studies it was matrix tablets prepared with method 2 shows heighest percent drug release and matrix tablet prepared by method 3 showed lowest percent drug release at the end of 8 hrs. (Shown in fig. 8, comparative release study of all three formulations). Matrix tablet of aceclofenac were successfully prepared and evaluated and it can be concluded that matrix tablet prepared with natural gums showed release rate for a prolonged time and can be of great importance for “once daily” tablet to reduce side effects and toxicity related with NSAIDs.  

Efficacy and safety of a novel water‐soluble herbal patch for acne vulgaris treatment: a randomized, assessor‐blinds controlled, intra‐individual split‐face comparative study

2021 ◽  
Author(s):  
Kulwipapat Jaturapisanukul ◽  
Montree Udompataikul ◽  
Silada kanolrungsee ◽  
Salinee Rojhirunsakool ◽  
Nanticha kamanamool ◽  
...  
Keyword(s):  
Comparative Study ◽  
Acne Vulgaris ◽  
Water Soluble ◽  
Efficacy And Safety ◽  
Split Face

New Carbohydrate-Based Polymeric Materials

MRS Bulletin ◽  
1992 ◽  
Vol 17 (10) ◽  
pp. 54-59 ◽  
Author(s):  
Matthew R. Callstrom ◽  
Mark D. Bednarski
Keyword(s):  
Food Additives ◽  
Polymeric Materials ◽  
Water Soluble ◽  
Natural Polymers ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
Chemically Modified ◽  
Stereochemical Control ◽  
Natural Polysaccharide ◽  
Image Position

The total world production of water-soluble polymers is estimated to be greater than five million tons per year. Water-soluble polymers are most conveniently described according to their origin in three classes (see Structures 1-6):∎ Natural polymers, including starch (1) and cellulose (2);∎ chemically modified natural polymers, including, for example, hydroxyethyl starch (3) and cellulose acetate (4); and∎ synthetic polymers, the most important of which are polyacrylamide (5) and polyvinyl alcohol (6), (commonly composed of both alcohol and acetate groups as shown). The widespread use of these materials is due to both their availability and the range of useful physical properties found in the various natural and chemically modified natural polymers.Of the commercial water-soluble polymers, approximately 50–80% are based on natural polysaccharide materials. One of the primary reasons that these materials find such widespread use is the dramatic response of their properties to changes in their functionality and stereochemistry: chemical modification or the combination of polysaccharides with other polymeric materials has yielded materials whose applications range from explosives to food additives. Although efforts directed at controlling the properties of polysaccharides has resulted in a wide variety of useful materials, we felt control of the composition of carbohydrate-based polymers at the molecular level would provide materials with properties superior to those derived from natural and chemically modified polysaccharide materials.Our approach for the preparation of new carbohydrate-based materials is to use the carbohydrate as a template for the introduction of desired functionality with complete regiochemical and stereochemical control by both chemical and enzymatic methods (Scheme I).

scholarly journals CARBOXYMETHYLATION OF POLYSACCHARIDES – A COMPARATIVE STUDY

2020 ◽  
Vol 54 (9-10) ◽  
pp. 835-844
Author(s):  
GABRIEL LARS ◽  
ANTJE TIED ◽  
THOMAS HEINZE
Keyword(s):  
Nmr Spectroscopy ◽  
Caustic Soda ◽  
Comparative Study ◽  
13C Nmr ◽  
Reaction Medium ◽  
13C Nmr Spectroscopy ◽  
Water Soluble

The present study describes the heterogeneous carboxymethylation of xylan,α-1,3-glucan, glucomannan, pullulan, curdlan, galactoglucomannan, and agarose with sodium monochloracetate (SMCA) using iso-propanol as slurry medium in the presence of caustic soda. Using heteropolysaccharides for the carboxymethylation, higher DS values are obtained compared to the DS of homopolysaccharides. The influence of the amount caustic soda in the reaction medium is studied. The characterization of the products obtained is performed by means of 13C-NMR spectroscopy. Carboxymethylation transforms the investigated polysaccharides into water-soluble products.

Comparative Study of Polymeric Supports as the Base of Immobilisation of Chemically Modified Enzymes

2006 ◽  
Vol 153 (3-4) ◽  
pp. 163-170 ◽  
Author(s):  
Susana de Marcos ◽  
Vanesa Sanz ◽  
Yolanda Andreu ◽  
Javier Galbán
Keyword(s):  
Comparative Study ◽  
Chemically Modified ◽  
Polymeric Supports

scholarly journals The Anti-Obesity Effect of Polysaccharide-Rich Red Algae (Gelidium amansii) Hot-Water Extracts in High-Fat Diet-Induced Obese Hamsters

Marine Drugs ◽  
2019 ◽  
Vol 17 (9) ◽  
pp. 532
Author(s):  
Yang ◽  
Chiu ◽  
Lu ◽  
Liu ◽  
Chiang
Keyword(s):  
Red Algae ◽  
Guar Gum ◽  
Uncoupling Protein ◽  
Water Extract ◽  
Diet Group ◽  
Water Soluble ◽  
Hot Water ◽  
Peroxisome Proliferator ◽  
High Fat ◽  
Gelidium Amansii

This study investigated the anti-obesity effect of a polysaccharide-rich red algae Gelidium amansii hot-water extract (GHE) in high-fat (HF) diet-induced obese hamsters. GHE contained 68.54% water-soluble indigestible carbohydrate polymers. Hamsters were fed with a HF diet for 5 weeks to induce obesity, and then randomly divided into: HF group, HF with 3% guar gum diet group, HF with 3% GHE diet group, and HF with orlistat (200 mg/kg diet) group for 9 weeks. The increased weights of body, liver, and adipose in the HF group were significantly reversed by GHE supplementation. Lower plasma leptin, tumor necrosis factor-α, and interleukin-6 levels were observed in the GHE+HF group compared to the HF group. GHE also increased the lipolysis rate and decreased the lipoprotein lipase activity in adipose tissues. GHE induced an increase in the phosphorylation of AMP-activated protein kinase (AMPK) and the protein expressions of peroxisome proliferator-activated receptor alpha (PPARα) and uncoupling protein (UCP)-2 in the livers. The decreased triglyceride and total cholesterol in the plasma and liver were also observed in obese hamsters fed a diet with GHE. These results suggest that GHE exerts a down-regulation effect on hepatic lipid metabolism through AMPK phosphorylation and up-regulation of PPARα and UCP-2 in HF-induced obese hamsters.

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