scholarly journals Optimizing noncontact oxygen‐plasma treatment to improve the performance of a top‐down nanofabricated surface enhanced Raman spectroscopy substrate with structurally responsive, high‐aspect‐ratio nanopillar array

Author(s):  
Robert B. Chevalier ◽  
Jason R. Dwyer
The Analyst ◽  
2015 ◽  
Vol 140 (24) ◽  
pp. 8080-8087 ◽  
Author(s):  
Pieter C. Wuytens ◽  
Ananth Z. Subramanian ◽  
Winnok H. De Vos ◽  
Andre G. Skirtach ◽  
Roel Baets

Top-down patterned gold nanodome microchips are taken up by living cells and serve as a uniform and reproducible sensor for intracellular surface-enhanced Raman scattering.


2015 ◽  
Vol 356 ◽  
pp. 1314-1319 ◽  
Author(s):  
Zhezhe Wang ◽  
Zhuohong Feng ◽  
Lin Lin ◽  
Pingping Huang ◽  
Zhiqiang Zheng

ACS Nano ◽  
2013 ◽  
Vol 7 (3) ◽  
pp. 2099-2105 ◽  
Author(s):  
Sean T. Sivapalan ◽  
Brent M. DeVetter ◽  
Timothy K. Yang ◽  
Thomas van Dijk ◽  
Matthew V. Schulmerich ◽  
...  

2017 ◽  
Author(s):  
Caitlin S. DeJong ◽  
David I. Wang ◽  
Aleksandr Polyakov ◽  
Anita Rogacs ◽  
Steven J. Simske ◽  
...  

Through the direct detection of bacterial volatile organic compounds (VOCs), via surface enhanced Raman spectroscopy (SERS), we report here a reconfigurable assay for the identification and monitoring of bacteria. We demonstrate differentiation between highly clinically relevant organisms: <i>Escherichia coli</i>, <i>Enterobacter cloacae</i>, and <i>Serratia marcescens</i>. This is the first differentiation of bacteria via SERS of bacterial VOC signatures. The assay also detected as few as 10 CFU/ml of <i>E. coli</i> in under 12 hrs, and detected <i>E. coli</i> from whole human blood and human urine in 16 hrs at clinically relevant concentrations of 10<sup>3</sup> CFU/ml and 10<sup>4</sup> CFU/ml, respectively. In addition, the recent emergence of portable Raman spectrometers uniquely allows SERS to bring VOC detection to point-of-care settings for diagnosing bacterial infections.


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