Contribution and limits of a non-intrusive Raman spectroscopic method compared with HPLC for routine application to pre-delivery analytical control of two major camptothecin analogs: irinotecan and topotecan

2015 ◽  
Vol 46 (12) ◽  
pp. 1283-1290 ◽  
Author(s):  
Alexandre Amin ◽  
Philippe Bourget ◽  
Flavie Ader ◽  
Fabrice Vidal ◽  
Cindy Neuzillet ◽  
...  
Keyword(s):  
Spectroscopic Method ◽  
Analytical Control ◽  
Raman Spectroscopic ◽  
Routine Application ◽  
Camptothecin Analogs

An in situ Raman spectroscopic method for quantification of polyethylene glycol (PEG) in waterlogged archaeological wood

Holzforschung ◽  
2020 ◽  
Vol 74 (11) ◽  
pp. 1043-1051
Author(s):  
Åke Henrik-Klemens ◽  
Katarina Abrahamsson ◽  
Charlotte Björdal ◽  
Alexandra Walsh
Keyword(s):  
Polyethylene Glycol ◽  
Spectroscopic Method ◽  
Calibration Model ◽  
Efficient Treatment ◽  
Raman Spectroscopic ◽  
Archaeological Wood ◽  
Validation Set ◽  
Impregnation Period ◽  
Polymer Impregnation

AbstractThe weakened microstructure of archaeological wood (AW) objects from waterlogged environments necessitates consolidation to avoid anisotropic shrinkage upon drying. Polymer impregnation through submergence or spraying treatments is commonly applied, and for larger and thicker objects, the impregnation period can stretch over decades. Thus, for efficient treatment, continuous monitoring of the impregnation status is required. Today, such monitoring is often destructive and expensive, requiring segments for extraction and chromatographic quantification. This study proposes an in situ Raman spectroscopic method for quantification of polyethylene glycol (PEG) in waterlogged AW. A calibration model was built on standards of PEG, cellulose powder, and milled wood lignin using orthogonal partial least squares (OPLS). The OPLS model had a strong linear relationship, and the PEG content in wood of varying degrees of degradation could be determined. However, the accuracy of the model was low with a root mean square error of prediction of 11 wt%. The low accuracy was traced to the heterogeneity in the calibration and validation set samples with regard to the small probing volume of the confocal instrumental setup.

scholarly journals NON-DESTRUCTIVE RAMAN SPECTROSCOPIC METHOD FOR ESTIMATION OF MONTELUKAST FROM TABLET DOSAGES FORM

2017 ◽  
Vol 9 (6) ◽  
pp. 161
Author(s):  
Jwal Doctor ◽  
Palak Thakkar ◽  
Mitul Prajapati ◽  
Nrupresh Patel ◽  
Priti J. Mehta
Keyword(s):  
Limit Of Detection ◽  
Process Analysis ◽  
Spectroscopic Method ◽  
Pharmaceutical Products ◽  
Integration Time ◽  
Limit Of Quantification ◽  
Raman Spectroscopic ◽  
Quality Checks ◽  
Technology Tool ◽  
Non Destructive

Objective: A rapid, non-destructive and non-solvent raman spectroscopic method for estimation of Montelukast from tablet dosages form Methods: Quantification was carried out by measuring the intensity of analyte peak at 1440 cm-1. Each Raman spectrum corresponded to an accumulation of 4 scans with an exposure time of 5 sec for each scan with a total integration time of 20 sec.Results: The method exhibited linearity between 2 mg-24 mg show well resolve quantification From MON. The linearity equation was calculated as y = 13.036x+70.819 and the correlation coefficient was found to be 0.997 for MON. LOD (limit of detection) and LOQ(limit of quantification) values were calculated using the calibration curve slope and standard deviation of the response. The LOD (limit of detection) and LOQ (limit of quantification) values were found to be 1.71 mg and 5.13 mg respectively.Conclusion: The developed method was successfully applied for assay of montelukast in the intact formulation. The method was validated according to an international conference on harmonisation guidelines. A recent study, montelukast sodium had been analysed by the raman method, but, looking into the tremendous potential of raman spectroscopic method; it can be extended as a process analysis and technology tool in various quality checks during manufacturing of pharmaceutical products.

Influence of Spectroscopic Techniques on the Estimation of the Degree of Conversion of Bulk-fill Composites

2020 ◽  
Vol 45 (1) ◽  
pp. 92-103 ◽  
Author(s):  
V Bolaños-Carmona ◽  
C Benavides-Reyes ◽  
S González-López ◽  
P González-Rodríguez ◽  
P Álvarez-Lloret
Keyword(s):  
Nonparametric Test ◽  
Total Reflection ◽  
Attenuated Total Reflection ◽  
Degree Of Conversion ◽  
Rank Test ◽  
Analytical Control ◽  
Spectroscopic Techniques ◽  
Raman Spectroscopic ◽  
Flowable Composites ◽  
Ft Raman

SUMMARY Objectives: To compare the degree of conversion (DC) of different flowable and sculptable bulk-fill composites (BFC), at 0- and 4-mm depths from the surface, by Fourier transform infrared (FTIR), attenuated total reflection FTIR (ATR-FTIR), and FT-Raman spectroscopic techniques. Methods and Materials: Six BFC were investigated, including three sculptable composites (Admira Fusion [Voco], Aura Bulk Fill [SDI], and X-tra Fill [Voco]) and three flowable composites (Venus Bulk Fill [Heraeus], Filtek [3M], and X-tra Base [Voco]). Three molds of each composite were light cured as specified by the manufacturer. For each mold, slices corresponding to 0-mm (surface) and 4-mm depth were analyzed by spectroscopic techniques: ATR-FTIR, FTIR, and FT-Raman. The spectra of uncured composite material were used as an analytical control for background subtraction of the treated composite. The area and amplitude of the reference peaks (1607 and 1637 cm−1) were obtained to calculate the DC percentage at 0- and 4-mm depth. A Kruskal-Wallis nonparametric test was used for materials, and paired comparisons were made using Mann-Whitney nonparametric test. Wilcoxon's rank test was used for comparison between spectroscopic methods and between 0- and 4-mm depth in each composite. Significance was accepted at p<0.05. Results: FTIR showed significantly lower DC values, both in areas and amplitudes of the peaks, when compared with the results reported by different BFC. Differences between the surface and 4-mm depth were detected more precisely by FT-Raman. ATR-FTIR obtained DC values significantly higher than those obtained by FTIR. Conclusions: The vibrational spectroscopy method significantly influenced DC measurements of the flowable and sculptable BFC explored.

scholarly journals Identification and Detection of Finasteride Polymorphs in Finasteride Tablets by FT-Raman Spectroscopy

2020 ◽  
Vol 32 (8) ◽  
pp. 1865-1868
Author(s):  
M. Chandra Sekhara Rao ◽  
R. Chenna Krishna Reddy ◽  
K.B. Chandra Sekhar ◽  
Y.V. Rami Reddy
Keyword(s):  
Raman Spectroscopy ◽  
Dosage Form ◽  
Spectroscopic Method ◽  
Weight Fraction ◽  
Polymorphic Form ◽  
Raman Spectroscopic ◽  
Solid Dosage ◽  
Ft Raman Spectroscopy ◽  
Tablet Preparation ◽  
Ft Raman

A simple FT-Raman spectroscopic method was developed for identification of finasteride polymorph form in finished dosage form. Finasteride polymorph form I was used in the tablet preparation and the weight fraction of finasteride in tablet was only about 0.023. The method was successfully used to identify the polymorphic form of finasteride in tablet and also to detect up to a level of about 15% of the other polymorph of finasteride present in the solid dosage. The dosage form was characterized by different techniques i.e. powdered X-ray diffraction, infrared spectroscopy and Raman spectroscopy. Based on literature survey, only Raman spectroscopy method is able to identify the polymorph of finasteride in dosage form.

scholarly journals A Simple Surface-Enhanced Raman Spectroscopic Method for on-Site Screening of Tetracycline Residue in Whole Milk

Sensors ◽  
2018 ◽  
Vol 18 (2) ◽  
pp. 424 ◽  
Author(s):  
Sagar Dhakal ◽  
Kuanglin Chao ◽  
Qing Huang ◽  
Moon Kim ◽  
Walter Schmidt ◽  
...  
Keyword(s):  
Spectroscopic Method ◽  
Raman Spectroscopic ◽  
Whole Milk ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Simple Surface

Raman Spectroscopic Method for Identification of Clinically Relevant Microorganisms Growing on Solid Culture Medium

2000 ◽  
Vol 72 (1) ◽  
pp. 12-19 ◽  
Author(s):  
Kees Maquelin ◽  
Lin-P'ing Choo-Smith ◽  
Tamara van Vreeswijk ◽  
Hubert Ph. Endtz ◽  
Brian Smith ◽  
...  
Keyword(s):  
Culture Medium ◽  
Spectroscopic Method ◽  
Solid Culture ◽  
Raman Spectroscopic ◽  
Solid Culture Medium
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