Spectroscopic study of inhibition of calcium oxalate calculi growth by Larrea tridentata

2011 ◽  
Vol 42 (3) ◽  
pp. 259-264 ◽  
Author(s):  
L. A. Pinales ◽  
R. R. Chianelli ◽  
W. G. Durrer ◽  
R. Pal ◽  
M. Narayan ◽  
...  
Keyword(s):  
Calcium Oxalate ◽  
Spectroscopic Study ◽  
Larrea Tridentata ◽  
Calcium Oxalate Calculi

scholarly journals Comparative spectroscopic analysis of nordihydroguaiaretic acid and related natural products to inhibition of calcium oxalate calculi

2019 ◽  
Vol 9 (3) ◽  
pp. 3942-3948 ◽  
Keyword(s):  
Natural Products ◽  
Calcium Oxalate ◽  
Morphological Changes ◽  
Nordihydroguaiaretic Acid ◽  
Larrea Tridentata ◽  
Crystal Formation ◽  
Calcium Oxalate Crystal ◽  
Diffusion Technique ◽  
Calcium Oxalate Calculi ◽  
Gel Diffusion

The prevalence of urolithiasis is still increasing worldwide. The goal of this study is to achieve a better understanding, from a comparative spectroscopic perspective, of the differences provided by chemical and natural products to the inhibitory processes of calculi formation. The research presented here places primary emphasis on the assessment of nordihydroguaiaretic acid (NDGA), the main chemical extract of the plant Larrea Tridentata, as a preventative to calcium oxalate crystal formation. It is also a logical continuation of our previous efforts using a traditional medicine approach to study such prevention. Complementary Raman and Fourier transformed infrared (FTIR) absorption analysis were used to provide a complete overview of morphological changes of calcium oxalate crystals, which were grown without and with the addition of NDGA at different concentrations. A gel diffusion technique was employed for sample preparation. Our results from both Raman and FTIR spectroscopies demonstrate that no structural transformation from a monohydrate to dehydrate occurs upon crystallization with NDGA, as we previously reported for the use of the natural plant infusion. Calculi synthesized with NDGA shows a distorted monohydrate morphology. Different effects inhibitory to calcium oxalate calculi formation are observed and analyzed here using chemical and natural extracts. If magnesium is the key to this difference, this study confirms its importance, not only in hundreds of metabolic pathways, but also in nephrological ones.

The Influence of Disodium Ethane-1-Hydroxy-1,1-Diphosphonate (Ehdp) on the Development of Experimentally Induced Urinary Stones in Rats

1972 ◽  
Vol 42 (2) ◽  
pp. 197-207 ◽  
Author(s):  
D. Fraser ◽  
R. G. G. Russell ◽  
Ortrun Pohler ◽  
W. G. Robertson ◽  
H. Fleisch
Keyword(s):  
Calcium Oxalate ◽  
Stone Formation ◽  
Ammonium Phosphate ◽  
Urinary Stones ◽  
Hydrogen Phosphate ◽  
Magnesium Ammonium Phosphate ◽  
Magnesium Ammonium ◽  
The Difference ◽  
Calcium Oxalate Calculi

1. Bladder stones composed of calcium hydrogen phosphate dihydrate, calcium oxalate mono- and di-hydrate and magnesium ammonium phosphate hexahydrate (struvite) were successfully induced in rats by various dietary manipulations and by implanting zinc pellets in the bladder. 2. The effect of a diphosphonate, disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP), given in the drinking water at concentrations of 0·0025, 0·05 and 0·5% (w/v), on the size and composition of these stones was examined. 3. All the concentrations of EHDP decreased the weight of the calcium oxalate calculi. In contrast, only the highest concentration of EHDP inhibited calcium hydrogen phosphate stone formation and the magnesium ammonium phosphate stones were unaffected. 4. The difference between the effects on calcium oxalate and magnesium ammonium phosphate stones is consistent with the finding that EHDP inhibited the precipitation of calcium oxalate from solution in vitro but had only a slight effect on magnesium ammonium phosphate precipitation. 5. It is suggested that EHDP might be of use in the prevention of some types of urinary stones in man.

Magnesium Oxide-pyridoxine Therapy for Recurrent Calcium Oxalate Calculi

1974 ◽  
Vol 112 (4) ◽  
pp. 509-512 ◽  
Author(s):  
Edwin L. Prien ◽  
Stanley F. Gershoff
Keyword(s):  
Calcium Oxalate ◽  
Magnesium Oxide ◽  
Calcium Oxalate Calculi

Hyperoxaluria in Patients with Recurrent Calcium Oxalate Calculi: Dietary and Other Risk Factors

1991 ◽  
Vol 68 (5) ◽  
pp. 454-458 ◽  
Author(s):  
N. A. LAMINSKI ◽  
A. M. MEYERS ◽  
M. KRUGER ◽  
M. I. SONNEKUS ◽  
L. P. MARGOLIUS
Keyword(s):  
Risk Factors ◽  
Calcium Oxalate ◽  
Calcium Oxalate Calculi

scholarly journals Internalization of Calcium Oxalate Calculi Developed in Narrow Cavities

2014 ◽  
Vol 2 (2) ◽  
pp. 51-53
Author(s):  
Fèlix Grases ◽  
Antonia Costa-Bauzá ◽  
Rafel M. Prieto ◽  
Antonio Servera
Keyword(s):  
Calcium Oxalate ◽  
Calcium Oxalate Calculi

scholarly journals Antilithiatic potential of Vernonia cinerea against calcium oxalate calculi in experimental rats

2017 ◽  
Vol 6 (2) ◽  
pp. 149-155
Author(s):  
Parveen Kumar Goyal ◽  
◽  
Santosh Kumar Verma ◽  
Anil Kumar Sharma ◽  
◽  
...  
Keyword(s):  
Uric Acid ◽  
Lactate Dehydrogenase ◽  
Ethylene Glycol ◽  
Calcium Oxalate ◽  
Creatinine Clearance ◽  
Ammonium Chloride ◽  
Biochemical Parameters ◽  
Calcium Phosphorus ◽  
Calcium Oxalate Calculi ◽  
Vernonia Cinerea

Objectives: The present manuscript was focused on evaluating the antilithiatic potential of Vernonia cinerea extract (VCE) against calcium oxalate calculi using experimental model. Methods: The drinking water containing ethylene glycol (0.75% v/v) and ammonium chloride (1% w/v) was used to induce hyperoxaluria in Wistar rats. Thirty-six rats, divided into following six groups (each containing six animals), were treated with vehicle (normal control), ethylene glycol and ammonium chloride (urolithic), Neeri (standard), 100, 300 and 500 mg/kg, VCE (tests). The experimental protocol involved the estimation of different biochemical parameters in urine, serum, kidney homogenates, and histopathological examinations of the kidney. Results: The urolithic rats showed the presence of oxalate crystals in renal tubules and significant changes in biochemical parameters like decreased creatinine clearance, increased urinary levels of oxalates, urea, calcium, phosphorus, uric acid, proteins, decreased urinary magnesium levels; increased serum levels of urea nitrogen, uric acid, calcium, phosphorus, lactate dehydrogenase; increased calcium, phosphorus, and oxalate contents in kidney homogenates. It altered the renal architecture and impaired the functions. The extract significantly (p< 0.05) reversed the biochemical changes in urine, serum and kidney homogenates in a dose-dependent manner. It improved the renal functions as indicated by improved creatinine clearance, reduced lactate dehydrogenase activity and restoration of renal architecture towards normal. Conclusions: Vernonia cinerea showed significant antilithiatic potential against oxalate calculi in glycolated rats.

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