Surface-enhanced Raman sensors: early history and the development of sensors for quantitative biowarfare agent and glucose detection

2005 ◽  
Vol 36 (6-7) ◽  
pp. 471-484 ◽  
Author(s):  
Christy L. Haynes ◽  
Chanda Ranjit Yonzon ◽  
Xiaoyu Zhang ◽  
Richard P. Van Duyne
Keyword(s):  
Early History ◽  
Glucose Detection ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Biowarfare Agent

Gold colloid-bienzyme conjugates for glucose detection utilizing surface-enhanced Raman scattering

Talanta ◽  
2006 ◽  
Vol 70 (3) ◽  
pp. 533-539 ◽  
Author(s):  
Zai-Sheng Wu ◽  
Gu-Zhen Zhou ◽  
Jian-Hui Jiang ◽  
Guo-Li Shen ◽  
Ru-Qin Yu
Keyword(s):  
Raman Scattering ◽  
Surface Enhanced Raman Scattering ◽  
Glucose Detection ◽  
Gold Colloid ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

A gold@silica core–shell nanoparticle-based surface-enhanced Raman scattering biosensor for label-free glucose detection

2014 ◽  
Vol 811 ◽  
pp. 76-80 ◽  
Author(s):  
Israa Al-Ogaidi ◽  
Honglei Gou ◽  
Abdul Kareem A. Al-kazaz ◽  
Zoraida P. Aguilar ◽  
Alice K. Melconian ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Surface Enhanced Raman Scattering ◽  
Core Shell ◽  
Glucose Detection ◽  
Label Free ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Free Glucose ◽  
Enhanced Raman Scattering ◽  
Silica Core

scholarly journals Glucose Detection of 4-Mercaptophenylboronic Acid-Immobilized Gold-Silver Core-Shell Assembled Silica Nanostructure by Surface Enhanced Raman Scattering

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 948
Author(s):  
Xuan-Hung Pham ◽  
Bomi Seong ◽  
Eunil Hahm ◽  
Kim-Hung Huynh ◽  
Yoon-Hee Kim ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Calibration Curve ◽  
Core Shell ◽  
Glucose Detection ◽  
Gold Silver ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Enhanced Raman Scattering ◽  
Silver Core

The importance of glucose in many biological processes continues to garner increasing research interest in the design and development of efficient biotechnology for the sensitive and selective monitoring of glucose. Here we report on a surface-enhanced Raman scattering (SERS) detection of 4-mercaptophenyl boronic acid (4-MPBA)-immobilized gold-silver core-shell assembled silica nanostructure (SiO2@Au@Ag@4-MPBA) for quantitative, selective detection of glucose in physiologically relevant concentration. This work confirmed that 4-MPBA converted to 4-mercaptophenol (4-MPhOH) in the presence of H2O2. In addition, a calibration curve for H2O2 detection of 0.3 µg/mL was successfully detected in the range of 1.0 to 1000 µg/mL. Moreover, the SiO2@Au@Ag@4-MPBA for glucose detection was developed in the presence of glucose oxidase (GOx) at the optimized condition of 100 µg/mL GOx with 1-h incubation time using 20 µg/mL SiO2@Au@Ag@4-MPBA and measuring Raman signal at 67 µg/mL SiO2@Au@Ag. At the optimized condition, the calibration curve in the range of 0.5 to 8.0 mM was successfully developed with an LOD of 0.15 mM. Based on those strategies, the SERS detection of glucose can be achieved in the physiologically relevant concentration range and opened a great promise to develop a SERS-based biosensor for a variety of biomedicine applications.

Synthesis of Silver Nanostructures and their Application in Highly Sensitive SERS Sensors

2017 ◽  
Vol 68 (1) ◽  
pp. 98 ◽  
Author(s):  
Alok Kumar Srivastava ◽  
Punam Awasthi ◽  
Sanjay Kanojia ◽  
N. S. Neeraj ◽  
Pankaj Sharma ◽  
...  
Keyword(s):  
Glass Substrate ◽  
Signal Enhancement ◽  
Silver Nanostructures ◽  
Sers Substrates ◽  
Highly Sensitive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Biowarfare Agent ◽  
Enhanced Raman Scattering ◽  
Chemical Synthesis Route

<p class="p1">A comparison of Surface Enhanced Raman Scattering (SERS) activity of chemically synthesised silver nanostructures with different shapes is reported. The silver nanostructures of cubical, prism and wire like morphology were synthesised using chemical synthesis route and utilised as SERS substrates. The sensors were fabricated by spin coating these materials over a Silicon or glass substrate. The fabricated sensors were used to analyse response with two different analytes, 4-Mercaptobenzoic acid and Rhodamine 6G under different concentrations. The signal enhancement was compared with a silver coated thin film over glass substrate and it was observed that the enhancement of the order of 10<span class="s1"><sup>3 </sup></span>is achieved. The nanowire performed better than the other forms of silver and gave a higher signal enhancement for all the analytes as compared to other nanostructures. The fabricated sensors may be useful for various applications including explosive and biowarfare agent detection.</p>

Optimized Silver Film over Nanosphere Surfaces for the Biowarfare Agent Detection Based on Surface-Enhanced Raman Spectroscopy

2005 ◽  
Vol 876 ◽  
Author(s):  
Xiaoyu Zhang ◽  
Richard P. Van Duyne
Keyword(s):  
Raman Spectroscopy ◽  
Silver Film ◽  
Diffuse Reflectance Spectroscopy ◽  
Limit Of Detection ◽  
Surface Enhanced Raman Spectroscopy ◽  
Infectious Dose ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Biowarfare Agent ◽  
Bacillus Spores

AbstractThis work presents the rapid detection of Bacillus subtilis spores, harmless simulants for Bacillus anthracis, using surface-enhanced Raman spectroscopy (SERS) on silver film over nanosphere (AgFON) substrates. Calcium dipicolinate (CaDPA), a biomarker for bacillus spores, can be extracted effectively from spores with nitric acid and successfully detected by SERS. The highly tunable nature of AgFON optical properties was exploited to establish general optimization conditions. AgFON surfaces optimized for 750-nm laser excitation have been characterized by UV-vis diffuse reflectance spectroscopy. The SERS signal from extracted CaDPA was evaluated over the spore concentration range 10-15-10-12M to determine the adsorption capacity of the AgFON surface and the limit of detection (LOD). These sensing capabilities have been successfully transitioned to an inexpensive, portable Raman spectrometer. Using the extraction method and this field-portable instrument, the anthrax infectious dose of 104spores were detected with only a 5-second collection period on a one-month-old prefabricated AgFON substrate.

scholarly journals Rapid Detection of Glucose on Nanostructured Gold Film Biosensor by Surface-Enhanced Raman Spectroscopy

Biosensors ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 54
Author(s):  
Cheng-Ju Sung ◽  
Szu-Han Chao ◽  
Shih-Chieh Hsu
Keyword(s):  
Raman Scattering ◽  
Rhodamine 6G ◽  
Surface Enhanced Raman Scattering ◽  
World Health ◽  
Quantitative Detection ◽  
Glucose Detection ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

In this report, we summarized our development of biosensors for Rhodamine 6G and in vitro glucose detection based on surface-enhanced Raman scattering technology. For the detection of both Rhodamine 6G and in vitro glucose, a nature-patterned substrate with gold films over nanostructures (NPS-AuFON) was used as the surface-enhanced Raman scattering sensor platform. The enhancement factor was calculated at 9 × 107. In the processing of the substrate, cyclic voltammetry was used to form nano-gold particles under different conditions. The Rhodamine 6G and glucose detection were then achieved on this substrate. Furthermore, we combined the potentiostatic technique and electrochemical adsorption to best detect glucose in low concentrations. The glucose oxidation potential (100 mV) was used to capture glucose close to the surface of the NPS-AuFON. The quantitative detection of glucose in solution and in situ inspection were confirmed. Further, we determined that this surface modification technology can reach the goal of experiments set by the World Health Organization to judge whether or not a patient is a diabetic by detecting a glucose concentration of 11.1 mmol/L (mg/dL) at a minimum.

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