A series of contributions to the question of the relation between chemical constitution and local anesthetic activity. IV. Local anesthetics containing an ephedrine-like nucleus

1939 ◽  
Vol 28 (8) ◽  
pp. 502-506
Author(s):  
W.A. Lott ◽  
W.G. Christiansen
Keyword(s):  
Local Anesthetic ◽  
Local Anesthetics ◽  
Anesthetic Activity ◽  
Local Anesthetic Activity ◽  
Chemical Constitution

scholarly journals Local Anesthetics: A Century of Progress

2020 ◽  
Vol 67 (4) ◽  
pp. 235-244
Author(s):  
John A. Yagiela
Keyword(s):  
Local Anesthesia ◽  
Local Anesthetic ◽  
Local Anesthetics ◽  
Pain Control ◽  
Clinical Use ◽  
Anesthetic Activity ◽  
Local Anesthetic Activity ◽  
Important Method ◽  
New Methods ◽  
Local Toxicity

Summary One century after the clinical introduction of cocaine, local anesthesia remains the most important method of pain control in dentistry. Many local anesthetics have been marketed since 1884, and it is likely that attempts to produce drugs that enhance anesthetic efficacy, reduce systemic and local toxicity, and increase nociceptive selectivity, will continue. In addition, new methods of drug administration have been and will be developed to achieve these goals. Of fundamental importance to such improvements are investigations into the pharmacology of drugs with local anesthetic activity and anatomical and physiologic studies pertaining to the reasons why local anesthetics sometimes fail to achieve desired results. This paper reviews recent advances in our understanding of these drugs and their clinical use.

ChemInform Abstract: SYNTHESIS AND LOCAL ANESTHETIC ACTIVITY OF 6-(Ω-AMINO-Ω-ARYLALKYL)BENZO-1,4-DIOXANES

1985 ◽  
Vol 16 (17) ◽  
Author(s):  
V. K. DAUKSHAS ◽  
YU. YU. RAMANAUSKAS ◽  
E. B. UDRENAITE ◽  
A. B. BRUKSHTUS ◽  
V. V. LAPINSKAS ◽  
...  
Keyword(s):  
Local Anesthetic ◽  
Anesthetic Activity ◽  
Local Anesthetic Activity
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