Transdermal Delivery of Narcotic Analgesics: Comparative Metabolism and Permeability of Human Cadaver Skin and Hairless Mouse Skin

1994 ◽  
Vol 83 (12) ◽  
pp. 1723-1728 ◽  
Author(s):  
S.D. Roy ◽  
S‐Y. E. Hou ◽  
S.L. Witham ◽  
G.L. Flynn
Keyword(s):  
Transdermal Delivery ◽  
Mouse Skin ◽  
Hairless Mouse ◽  
Human Cadaver ◽  
Narcotic Analgesics ◽  
Hairless Mouse Skin ◽  
Comparative Metabolism ◽  
Human Cadaver Skin ◽  
Cadaver Skin

scholarly journals Transdermal delivery of FITC-Dextrans with different molecular weights using radiofrequency microporation

2020 ◽  
Vol 24 (1) ◽  
Author(s):  
Guk Young Ahn ◽  
Hae-Seok Eo ◽  
Dongwon Kim ◽  
Sung-Wook Choi
Keyword(s):  
Transdermal Delivery ◽  
Fluorescein Isothiocyanate ◽  
Optical Microscope ◽  
Human Cadaver ◽  
Diffusion Cell ◽  
Franz Diffusion Cell ◽  
Molecular Weights ◽  
Pig Skin ◽  
Human Cadaver Skin ◽  
Cadaver Skin

Abstract Background Transdermal delivery is of great importance for the effective delivery of bioactive or therapeutic agents into a body. The microporation device based on radiofrequency can be used to enhance delivery efficiency by removing the epidermis layer. Methods The micropores were developed on pig skin and human cadaver skin with dermal and epidermal layers by the microporation device. The regeneration of micropores in the human cadaver skin caused by microporation was confirmed using an optical microscope and haematoxylin/eosin (H&E) staining. The permeability of fluorescein isothiocyanate-dextrans (FITC-dextrans) with different molecular weights through the pig and human cadaver skins were measured using Franz diffusion cell. Results The optical image and histological analysis confirmed that the micropores on the skin were recovered over time. The enhanced permeability through micropores was confirmed by Franz diffusion cell. The lower molecular weight of FITC-dextran permeated more on both human and pig skin. In addition, the permeation rate was higher in pig skin than in human skin. Conclusions We believe that the microporation device can be used as a potential technique for effective transdermal drug delivery.

scholarly journals Nanoemulsions as vehicles for transdermal delivery of glycyrrhizin

2011 ◽  
Vol 47 (4) ◽  
pp. 769-778 ◽  
Author(s):  
Ranjit Kumar Harwansh ◽  
Kartik Chandra Patra ◽  
Surendra Kumar Pareta ◽  
Jagadish Singh ◽  
Mohammed Akhlaquer Rahman
Keyword(s):  
Transdermal Delivery ◽  
Isopropyl Alcohol ◽  
Skin Permeation ◽  
Skin Irritation ◽  
Human Cadaver ◽  
Permeation Enhancers ◽  
Brij 35 ◽  
Human Cadaver Skin ◽  
Cadaver Skin ◽  
Span 80

The present investigation aims to evaluate an isotropic and thermodynamically stable nanoemulsion formulation for transdermal delivery of glycyrrhizin (GZ), with minimum surfactant and cosurfactant (Smix) concentrations that could improve its solubility, permeation enhancement, and stability. Pseudo-ternary phase diagrams were developed and various nanoemulsion formulations were prepared using soyabean oil as oil, Span 80, Brij 35 as a surfactant and isopropyl alcohol as a cosurfactant. Nanoemulsion formulations that passed the thermodynamic stability tests were characterized for pH, viscosity and droplet size using a transmission electron microscopy. The transdermal ability of glycyrrhizin through human cadaver skin was determined using Franz diffusion cells. The in vitro skin permeation profile of the optimized nanoemulsion formulation (NE2) was compared to that of conventional gel. A significant increase in permeability parameters such as steady-state flux (Jss) and permeability coefficient (Kp) was observed in the optimized nanoemulsion formulation (NE2), which consisted of 1% wt/wt of mono ammonium glycyrrhizinate (MAG), 32.4% Span 80, 3.7% Brij 35, 10% isopropyl alcohol, 46.5% soyabean oil and 6.4% distilled water. No obvious skin irritation was observed for the studied nanoemulsion formulation (NE2) or the gel. The results indicated that nanoemulsions are promising vehicles for transdermal delivery of glycyrrhizin through human cadaver skin, without the use of additional permeation enhancers, because excipients of nanoemulsions act as permeation enhancers themselves.

scholarly journals Iontophoretic transdermal delivery of buspirone hydrochloride in hairless mouse skin

AAPS PharmSci ◽  
2003 ◽  
Vol 5 (2) ◽  
pp. 61-71 ◽  
Author(s):  
Mohammad Al-Khalili ◽  
Victor M. Meidan ◽  
Boeena B. Michniak
Keyword(s):  
Transdermal Delivery ◽  
Mouse Skin ◽  
Hairless Mouse ◽  
Hairless Mouse Skin ◽  
Buspirone Hydrochloride
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