Pharmacokinetics of Intranasal Drug Administration: The Influence of Some Biological Factors

1991 ◽  
Vol 80 (5) ◽  
pp. 505-506 ◽  
Author(s):  
Sveinbjörn Gizurarson ◽  
Søren N. Rasmussen ◽  
Frank Larsen
Keyword(s):  
Drug Administration ◽  
Biological Factors ◽  
Intranasal Drug Administration

Direct access of drugs to the human brain after intranasal drug administration?

Neurology ◽  
2003 ◽  
Vol 60 (10) ◽  
pp. 1669-1671 ◽  
Author(s):  
P. Merkus ◽  
H.-J. Guchelaar ◽  
D. A. Bosch ◽  
F. W.H.M. Merkus
Keyword(s):  
Human Brain ◽  
Drug Administration ◽  
Direct Access ◽  
Intranasal Drug Administration

Treatment of malaria in a mouse model by intranasal drug administration

2006 ◽  
Vol 36 (14) ◽  
pp. 1493-1498 ◽  
Author(s):  
Elka Touitou ◽  
Judith H. Waknine ◽  
Biana Godin ◽  
Jacob Golenser
Keyword(s):  
Mouse Model ◽  
Drug Administration ◽  
Intranasal Drug Administration

Strategies for nose-to-brain drug delivery

2019 ◽  
Author(s):  
Rodrigo Quispe ◽  
Jorge A. Trevino ◽  
Faizan Khan ◽  
Vera Novak
Keyword(s):  
Drug Delivery ◽  
Clinical Trials ◽  
Drug Administration ◽  
Drug Uptake ◽  
Supporting Evidence ◽  
Drug Bioavailability ◽  
Brain Drug Delivery ◽  
Potential Efficacy ◽  
Intranasal Drug Administration ◽  
The Brain

"Intranasal drug administration is an effective method that has shown promise for delivering drugs directly to the brain. This approach is associated with many challenges, and efficacy in bypassing blood-brain barrier (BBB) is debated. This review describes the pathways of nose-to-brain drug delivery, physicochemical drug properties that influence drug uptake through the nasal epithelium, physiological barriers, methods to enhance nose-to-brain absorption, drug bioavailability and biodistribution, and intranasal devices for nose-to-brain drug delivery. The mechanism of each device is described and supporting evidence from clinical trials is presented. This paper summarizes strategies involved in nose-to-brain drug delivery and provides evidence of potential efficacy of nose-braindelivery from clinical trials."

Biological Factors in Behavior: A Break with Tradition

1975 ◽  
Vol 20 (7) ◽  
pp. 557-558
Author(s):  
PAUL ELLEN
Keyword(s):  
Biological Factors

Evolution of Biological Factors in Learning

1985 ◽  
Vol 30 (2) ◽  
pp. 107-109
Author(s):  
Michael Domjan
Keyword(s):  
Biological Factors
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